Discrimination of phenethylamine regioisomers and structural analogues by Raman spectroscopy

In this study, the Raman spectra of 21 phenethylamines were obtained using far‐red excitation (785 nm). The distinguishing ability of Raman for phenethylamines, especially for phenethylamine regioisomers and structural analogues, was investigated. Here, the evaluation of a cross section of Raman spectra demonstrated that all types of phenethylamines were distinguishable, even for certain structural analogues with high spectrum similarity. Raman exhibited high distinguishing ability for phenethylamine regioisomers that differ in the substitution position of halogen, methoxy, alkyl, or other substituted groups; as well as for structural analogues containing different groups, such as furanyl, 2,3‐dihydrofuranyl, halogen, and alkyl substituted at the same position. The Raman spectra for homologues with differences in only a methyl group were found to be highly similar; however, their spectra demonstrated small but detectable differences. Four analogue mixtures and 59 seized samples were also analyzed to study the practical use of the Raman method in forensic field. 95% of the seized samples were correctly identified, which significantly validated the ability of Raman method in identifying the correct isomers. Accordingly, this study provides a non‐destructive, high‐throughput and minimal sample preparation technique for the discrimination of phenethylamines.     

论美国法官的判决

<正> 目前,人们对美国法官作出的判决议论纷纷,有的人指责法官作出的判决过于宽大,有的则批评法官在作判决时滥用职权。不管是自由主义者还是保守主义者都一致提出判决制度要改革。判决改革的呼声,说明目前的判决确是存在着一些问题。这主要表现是:一、判决的混乱性女演员 Claudine Longet 杀了自己的男朋友,科罗拉多州的爱司伯法院给予了她监禁30天的判决;而长岛的一个外科医生由于在一个三角恋爱中杀了自己的妻     

SPE-HPLC/MS/MS检验体液中赛拉嗪及DMA

目的建立了一种高效液相色谱串联三重四极杆质谱同时测定体液中赛拉嗪及2,6-二甲基苯胺的分析方法。方法样品经HLB固相萃取柱提取净化,Waters Atlantis d C18色谱柱分离,正电离条件下进行选择监视扫描模式检测。结果方法的回收率为70.5%~79.8%,RSD为8.2%~10.5%。赛拉嗪及2,6-二甲基苯胺在血液和尿液中的检出限分别为0.4 ng/mL和0.3 ng/mL,定量限分别为1.2 ng/mL和1.0 ng/mL。结论本方法灵敏度高、特异性好、重现性好,适用于赛拉嗪中毒的血液和尿液检测。     

论无船承运人的海事赔偿责任

无船承运人具有契约承运人和契约托运人的双重身份，本文分析了无船承运人应当承担的海事赔偿责任的归责原则、责任内容及其与实际承运人的连带赔偿责任如何认定的问题。     

解读新“INTERNET条约”——《WIPO保护广播组织条约草案》述评

《WIPO保护广播组织条约草案》反映了现代传播技术发展背景下广播组织的时代需要,它扩大了广播组织主体的范围,增加了广播组织的权利内容,强化了对技术措施的保护,并在均衡广播组织与广大公众之间利益的基础上,规定了权利的例外与限制.《WIPO保护广播组织条约》的即将出台,将和WIPO的另两个条约WCT和WPPT共同构成一个完整的"INTERNET条约"体系,对我国著作权法将产生重大影响.     

Population genetics for Y-chromosomal STRs haplotypes of Chinese Tibetan ethnic minority group in Tibet

Y-chromosomal STRs loci were analyzed from a sample of 119 healthy unrelated autochthonous male individuals of Chinese Tibetan ethnic minority group using a multiplex PCR system. Allele and haplotype frequencies for DYS19, DYS389 I, DYS389 II, DYS390, DYS391, DYS392, DYS393, DYS385a,b, DYS438, and DYS439 were determined by the Y-PLEXtrade mark 12 kit. The gene diversity values for the Y-STRs loci ranged from 0.3347 (DYS438) to 0.9547 (DYS385a,b). A total of 110 haplotypes were identified in the Y-STR loci, among which 104 were unique, while six occurred more than once. The overall haplotype diversity for the Y-STRs loci was 0.9981, and the discrimination capacity was 0.9897. The results in the present study can be used for routine forensic application in the region, and enrich Chinese ethnical genetic informational resources.     

犯罪对象概念的反思与重构

刑法学者之所以在不同场合赋予犯罪对象不同含义,是因为我国刑法理论中的传统犯罪对象概念存在一定的缺陷。有必要重构犯罪对象概念,将“犯罪行为直接作用的具体人和物”与“犯罪客体的直接物质承担者”两种含义适当分离,在理论上区分为直接犯罪对象与间接犯罪对象,二者作为犯罪实行行为指向的事物,有时可发生部分重合,但功能上并不相同,不可相互替代。     

Licensed firearm dealers,legal compliance,and local homicide: A case study

Research summary

This study uses a combination of tract-level and street network-level analyses to examine: (1) the overall association between federally licensed firearm dealers (FFLs) and homicides, (2) the relationship between dealers with serious violations (such as selling to prohibited buyers or failing to record sales) and homicide, and (3) whether the dealer–homicide association is moderated by community disadvantage. Results replicate and confirm a relationship between dealers and homicides in disadvantaged neighborhoods. Importantly, however, we also find that proximity to noncompliant dealers specifically elevates the risk of lethal violence.

Policy implications

We detail how a coordinated effort between federal, state, and local agencies to regulate firearm dealers and ensure that legal compliance can be instrumental in reducing gun violence. There is a clear need for increased oversight of gun dealers and more robust policies that hold negligent dealers accountable, including the necessary funding and regulatory manpower to enable regular auditing and support consistent follow-up for noncompliant dealers. A comprehensive policy framework that supports supply-side gun violence reduction should include additions to state-level laws that require record keeping, videotaping and store security, and regular inspection for firearm dealers.     

行政裁量的本质论与运行论

行政裁量是现代行政任务和行政功能变化的产物,其目的在于追求个案的正当性,减少立法成本,促进行政效能。从本质上看,行政裁量是一种行政机关的单方意思表示,是行政机关对法律效果的自由选择行为,从而与作为判断权范畴的不确定性概念相区别。由于行政裁量所包含的“主观意志性”的非理性因素极容易导致行政裁量权被滥用,为此,现代国家设计了各种规则和制度将其纳入到一定的框架之中,以实现行政法治理性。     

大鼠脑挫伤后巢蛋白表达与脑挫伤经过时间的关系

目的观察大鼠脑挫伤后不同时间内巢蛋白(nestin)蛋白表达的变化,探讨其与脑损伤经过时间的关系。方法利用自由落体撞击大鼠脑挫伤模型,在脑挫伤后不同时间(0.5,6,12h和1,3,7,14,28d)观察nestin蛋白在伤侧皮质、海马齿状回及胼胝体表达情况。结果伤后0.5h伤侧皮质、海马齿状回及胼胝体nestin阳性细胞表达开始增强,7d达高峰,以后逐渐下降,28d伤侧皮质、海马齿状回恢复至正常组水平,伤侧胼胝体在伤后28d仍有弱表达。结论nestin免疫组化染色可以作为法医学推断早期脑损伤时间的指标之一;nestin可作为判断脑损伤是否存在及区分生前和死后脑损伤的标志。