The analytical profile of some 4-methylthioamphetamine (4-MTA) homologues

The 4-methylthioamphetamine (4-MTA) is a sulphur-containing amphetamine-type stimulant (ATS), which appeared on the illicit market in Europe at the end of 90s. For the purpose of this study, several N-alkyl homologues of 4-MTA, including 4-methylthiomethamphetamine (4-MTMA), 4-methylthioethylamphetamine (4-MTEA), 4-methylthiodimethamphetamine (4-MTDMA), 4-methylthiopropylamphetamine (4-MTPA) and 4-methylthiobutylamphetamine (4-MTBA) were synthesized. The homologues were characterized by means of gas chromatography/mass spectrometry (GC–MS), infrared (IR) spectroscopy and the magnetic resonance spectroscopy (¹H and ¹³C NMR). The gas chromatography and mass spectrometry properties of their acetyl, trifluoroacyl (TFA), pentafluoropropionyl (PFP) and heptafluorobutyryl (HFB) derivatives were also investigated and discussed.     

Some pyridine derivatives as "route-specific markers" in 4-methoxyamphetamine (PMA) prepared by the Leuckart Method Studies on the role of the aminating agent in their distribution in the final product

The two previously unknown isomeric aryl-methylpyridines were prepared and analysed. Both 2,6-dimethyl-3,5-(4'-methoxyphenyl)pyridine and 2,4-dimethyl-3,5-di-(4'-methoxyphenyl)pyridine have been identified as a new by-product in the crude 4-methoxyamphetamine (PMA) obtained via the Leuckart method. The synthesis of 2,6-dimethyl-3,5-diphenylpyridine, which is connected to amphetamine chemistry, is also reported. It was also found that different reagents (formamide, formamide/HCOOH, ammonium formate) used in the course of the Leuckart synthesis of PMA significantly affected the impurity content. The presented results point out on the "high-boiling pyridines" as compounds especially useful in the comparative analysis, since their profile seems to be independent on the purification procedure and may be conveyed from the crude reaction mixture even into a carefully purified final product.     

Regulatory induced herding? Evidence from Polish pension funds

The paper documents herding among pension fund managers in Poland. Herding occurs despite the lack of an economically significant link between fund performance and the flow of new capital or members. To explain this phenomenon, the paper outlines a model that attributes herding to performance incentive contracts imposed by the authorities in Poland. The model shows that penalties for underperformance imposed by the regulator are likely to cause fund managers to follow each other’s portfolio choices and pursue similar investment strategies. Since herding causes similar portfolio allocations by all funds, the results call for a reduction in the number of funds, or a review of the relative performance incentive system and current constraints on portfolio allocation. The latter could also help reduce the dominance of government bonds in investment portfolios of pension funds.     

Hyperpigmentation in the long bones of the lower limbs as a basis for vehicle identification and traffic accident reconstruction

Following the earlier studies on the identification of injuries in unbroken cranial bones, the described method was adapted for the examination of the long bones in fatal casualties of traffic accidents.Two types of bumper injuries might occur: the bumper was found to cause fracturing of limbs [1], and femoral muscle contusions and microtraumas within compact and spongiose parts in the femoral with subsequent maculate hyperpigmentation [2].The authors show that the correlation of above mentioned traces of the trauma, facilitates the reconstruction of the accident and also the identification of the vehicle.     

The State of Enslavement: the East European Substitute for the State of Nature

Comparing the Soviet-type political system before the emergence of independent groups and movements with the state of nature in the contractarian tradition indicates that both these conditions havecommon features. The situation under the Soviet-type system is reminiscent of the state of nature since it has a pre-political, analytical, as well as a normative character. However, the Fact that the condition under the Soviet-type system is real and the state of nature is fictive poses a challenge to social contract orthodoxy which exclusively ascribes the pre-political and normative components to the state of nature. This interpretation renders invalid the main argument of the critics of contractarianism: that social contract theory is based upon the fictive state of nature and, therefore, upon the concept of an abstract human nature. Moreover, under special circumstances, it permits us to consider social contract theory not only as normative but also as empirical     

Some Thoughts on Civil Society in Eastern Europe and the Lockean Contractarian Approach

Neither the concept of the totalitarian system nor the newly worked-out notion of 'socialist civil society' can express the social and political phenomenon of the rise and growth of independent groups and movements in Eastern Europe. Rather, it is suggested here that the Lockean contractarian approach should be used. This embraces mutually interacting ethical, empirical and analytic arguments which would take into consideration the state, the independent groups organized outside it, and the relationships between them. The utility of the model of the totalitarian state in understanding the origin of independent groups is discussed here. Lockean multidimensional individualism is suggested as a category expressing the political character of these groups, and Lockean teaching on absolute monarchy—a special form of the state of nature—is advanced as the means for analysing the relationship between these groups and the state of the Soviet type.     

Identification of common impurities present in the synthetic routes leading to 4-methylthioamphetamine (4-MTA). Part II: Reductive amination and nitropropene route

In this paper the by-products arising during the synthesis of 4-methylthioamphetamine (4-MTA) by LiAlH(4) reduction of 1-(4-methylthiophenyl)-2-nitropropene (nitropropene route) and reductive amination of 4-methylthiophenyl-2-propanone in the presence of NaCNBH(4) are investigated. The identification of 4-methylthio derivatives of N-(β-phenylisopropyl)benzaldimine, 4-methylthio derivative of N-(β-phenylisopropyl)benzyl methyl ketimine, 1-(4-methylthiophenyl)-N-(4-methylthiobenzyl)-2-propanamine, (RS) and (SS/RR)-N,N-di-[β-(4-methylthiophenyl)isopropyl]amine, 4-methylthiobenzyl ether and methylthiobenzoic acid methyl ester as most prominent impurities in crude 4-MTA synthesised by reductive amination of 4-methylthiophenyl-2-propanone, is reported. Methylthio derivatives of 2-methyl-3-phenylaziridine, 2-benzylaziridine, and 4-methylthio derivative of BMK oxime as route-specific markers of nitropropene route leading to 4-MTA, were also characterized. The identity of these compounds was confirmed by their independent synthesis.