A Windows-based software for common paternity and sibling analyses

A new Windows-based freeware for kinship analysis from DNA data is presented. This software can be used to calculate likelihood ratios and probabilities of paternity in trio and motherless cases, as well as in cases when a parent is lacking but there are data from the grandparents. It can also be used to compute the probability of two subjects being full-brothers or half-brothers.     

A market based evaluation of the election versus appointment of regulatory commissioners

This paper examines the elected versus appointed commissioner dichotomy from a market value perspective. Previous empirical analysis tends to concentrate on rates rather than examining the impact on shareholders' wealth. We examine life insurance industry data during the period surrounding the passage of California's Proposition 103. The primary impact of the referendum on life insurers is to change the method of commissioner selection from appointment to popular vote. We find that this change significantly reduced the value of life insurers doing business in California. This result is consistent with the recent findings of Boyes and McDowell (1989) and Smartt (1994) using alternative evaluation procedures for firms in other regulated industries. This implies that the change to a popular election of commissioners either increases the level of risk and/or decreases the expected cash flows of regulated firms.     

Anticipated Transition to Adulthood: The Effect of Educational Track,Gender, and Self-Evaluation on Finnish and Polish Adolescents' Future Orientation

In Finland and Poland, a total of 352 (192 boys and 160 girls) 17-year-old general secondary and vocational school students participated in a study investigating their anticipated transition to adulthood. In times of large sociohistorical change in both countries, Finland (economic depression) and Poland (change from socialism to market economy), we investigated to what extent those changes were reflected in the students' probability estimations (for potential goal attainment in three future life domains; education, occupation and family life), generational comparison (attaining a life different from the life of parents), future time extension (for anticipated events in those life domains), and self-evaluations (self-esteem and control over future). The results showed that girls in both countries expressed a higher level of probability for success in education than boys did. As expected, vocational school students in both countries expressed a lower probability of success in future occupation than general secondary school students did. General secondary school students from both countries expressed higher levels of self-esteem and control over future than vocational school students did. Unexpectedly, no differences between boys' and girls' probability estimations for family life were found, in either country. However, girls from both countries anticipated an earlier and more rapid transition to adulthood than boys did, thus reflecting social time tables. The results suggested that the educational track remains a significant stratifying factor in times of societal change in both countries.     

Genetic profile of the Ecuadorian Mestizo population (Ecuador-South America) by using the Power Plex 16 System Kit

Allele frequency data for the 15 STR systems and Amelogenine were determined in a population sample of healthy Mestizo unrelated individuals. All loci met Hardy-Weinberg expectations and the high discrimination power of combined system showed the forensic efficiency of these genetic markers. There is a lack of information on Ecuadorian population from a genetic point of view and therefore no previous publications on the distribution of STRs on Mestizos is available. Mestizos are descendents of Spanish and Amerindian people, however, significant differences were found between the former and the populations from Spanish peninsula, that have been analyzed for these genetic markers.     

Bone as a biomarker of acute fluoride toxicity

The use of bone as a biomarker for chronic and acute exposure to fluoride salts has been suggested, but there are no data published about its use to evaluate lethal intoxication. One hundred and sixty rats were divided into eight groups that received a single oral intubation dose from 0 (control) to 90 mg F/kg as NaF. The animals' time of death was recorded and their femurs were removed for fluoride analysis. Acid-soluble fluoride was determined in the whole bone and on the surface (periosteal), using an ion specific electrode. The data showed a statistically significant relationship between fluoride dose and the number of deaths (P<0.0001). A statistically significant relationship was also found between fluoride dose and fluoride concentration ([F]) in either the whole femur (P<0.0017), on the surface (P<0.0001) or for the ratio periosteal [F]/whole [F] (P<0.0001). However, the [F] on the femur surface was more closely correlated with mortality than that in the whole bone, showing statistically significant differences among the lethal doses and control (P<0.05). The data suggest that the ratio [F] periosteal bone/[F] whole bone, is a biomarker for acute fluoride toxicity.     

Allele frequencies of 15 STR loci in the population of the city of Quito, Ecuador

POPULATION: Quito City population (Ecuador, South America, n = 116-207).     

Reporting a fatality during tumescent liposuction

Deaths of patients during elective surgery have drawn attention to the danger of anesthesia. Tumescent local anesthesia is subcutaneous infiltration of large volumes of dilute lidocaine with epinephrine to produce vasoconstriction while delivering anesthesia over large areas without lidocaine toxicity. This report documents the case of a 38-year-old woman who attended an outpatient clinic to undergo liposuction of the abdomen and bilateral hips and thighs. According to one witness, around 30 min after anesthesia administration, the victim suffered an episode of tonic–clonic convulsion. When the emergency medical services arrived the patient was in asystole. She died in spite of attempted cardiopulmonary resuscitation. The patient had no significant past medical history including no history of allergies or any known complications with anesthesia. A complete autopsy was performed and possible causes of death such as myocardial infarction, aspiration of food or foreign body, and pulmonary embolism were discarded. Anaphylactic shock was considered a possible but unlikely explanation for the fatality. Toxicological analyses revealed the presence of lidocaine and mepivacaine in heart blood, at concentrations of 4.9 and 16.2 mg/L, respectively. All drugs involved in the case were detected using gas chromatography with nitrogen–phosphorus detector and confirmed using gas chromatography–mass spectrometry full scan mode after solid-phase extraction using Chem-Elut columns. An additional high-performance liquid chromatography coupled to diode-array detection screening also obtained the same results. Based on the autopsy findings, case history, and toxicology results, the forensic pathologists ruled that the cause of death was an overdose of local anesthetic agents. The Court of Law ruled the death as an involuntary homicide due to gross negligence.