Concentrations of unconjugated morphine, codeine and 6-acetylmorphine in urine specimens from suspected drugged drivers

Concentrations of unconjugated morphine, codeine and 6-acetylmorphine (6-AM), the specific metabolite of heroin, were determined in urine specimens from 339 individuals apprehended for driving under the influence of drugs (DUID) in Sweden. After an initial screening analysis by immunoassay for 5-classes of abused drugs (opiates, cannabinoids, amphetamine analogs, cocaine metabolite and benzodiazepines), all positive specimens were verified by more specific methods. Opiates and other illicit drugs were analyzed by isotope-dilution gas chromatography-mass spectrometry (GC-MS). The limits of quantitation for morphine, codeine and 6-AM in urine were 20 ng/mL. Calibration plots included an upper concentration limit of 1000 ng/mL for each opiate. We identified the heroin metabolite 6-AM in 212 urine specimens (62%) at concentrations ranging from 20 ng/mL to > 1000 ng/mL. The concentration of 6-AM exceeded 1000 ng/mL in 79 cases (37%) and 31 cases (15%) were between 20 and 99 ng/mL. When 6-AM was present in urine the concentration of morphine was above 1000 ng/mL in 196 cases (92%). The concentrations of codeine in these same urine specimens were more evenly distributed with 35% being above 1000 ng/mL and 21% below 100 ng/mL. These results give a clear picture of the concentrations of unconjugated morphine, codeine and 6-acetylmorphine that can be expected in opiate-positive urine specimens from individuals apprehended for DUID after taking heroin.     

Y-chromosome variation in Rio de Janeiro,Brazil, population sample

Allele and haplotype frequencies of seven Y-chromosome STR loci, DYS 19, DYS388, DYS389I, DYS389II, DYS390, DYS391 and DYS392, were determined from 109 unrelated males in Rio de Janeiro, Brazil, sample population.     

Identification of anhydroecgonine ethyl ester in the urine of a drug overdose victim

Toxicological evaluation of postmortem urine collected from a 41-year-old deceased white male detected anhydroecgonine ethyl ester (ethylecgonidine, AEEE), a transesterification product of smoked cocaine co-abused with ethanol. A solid phase extraction (SPE) method was used to extract cocaine, AEEE, and related metabolites from urine. SPE on a 1 mL urine sample from the decedent followed by GC-MS detected AEEE. Other metabolites identified by GC-MS included cocaine, cocaethylene, and anhydroecgonine methyl ester (AEME). To determine whether some or all of the AEEE was artifactually produced in the heated GC injector port, an alternative LC-MS method was developed. LC/MS following SPE found at least 50 ng/mL of AEEE in the extract. The mass fragmentation (MS/MS and MS3) of AEEE detected in the urine was compared to spectra of authentic, synthesized compound. AEEE is a potential additional forensic marker for the co-abuse of smoked cocaine and ethanol.     

Testing for Publication Bias in Political Science

If the publication decisions of journals are a function of thestatistical significance of research findings, the publishedliterature may suffer from "publication bias." This paper describesa method for detecting publication bias. We point out that toachieve statistical significance, the effect size must be largerin small samples. If publications tend to be biased againststatistically insignificant results, we should observe thatthe effect size diminishes as sample sizes increase. This propositionis tested and confirmed using the experimental literature onvoter mobilization.     

Kevin Vallier: Must politics be war? Restoring our trust in the open society. Oxford University Press,New York,NY, 2019, 243p,USD 90.00 (hardback)

Public Choice - Why do politicians rebel and vote against the party line when high stakes bills come to the floor of the legislature? To address that question, we leverage the three so-called...     

Initiative-Resistance and the Australian Party System

In the first half of the twentieth century, writing about Australian political parties was strongly influenced by the novelty of government — and the policy agenda — being led by the political arm of organised labour. This was reflected in the tendency for commentators to treat Labor as the driving force in Australian politics and policy, and to see non-Labor as playing a predominantly reactive and oppositional role. Following strong criticism, the “initiative-resistance thesis”, as this perspective was termed, lapsed. Here we revisit the concept, tracking its origins, use, and ultimate demise in the 1960s, and reconsider its validity and relevance, particularly in light of its affinity with the international literature on the “impact of parties”. While initiative-resistance was never a “thesis” as such, and critics have overstated the hold it enjoyed in early accounts, we argue that there is merit to a version reformulated in clear propositional terms. Critics may also have overstated its weaknesses. We illustrate this by focusing on one of the main original criticisms: the need to do justice to the separate identity of the National Party in understanding an essentially two-party system.     

Domestic Attitudes Towards International Jurisdiction over Human Rights Violations

Building on research regarding the influence of national identity salience on attitudes towards international institutions and the impact of nationalism on foreign policy preferences, in a case study of America, I explore the role of chauvinistic nationalism to understand its impact on attitudes towards international jurisdiction of punishment for alleged human rights violations by members of the American military. Using binomial regression of survey responses from the 2014 Cooperative Congressional Election Study, I find that respondents with higher levels of chauvinistic nationalist sentiment also have higher levels of opposition to the jurisdiction of international legal institutions to prosecute members of a nation’s military. This study is the first of its kind to offer a systematic and multivariate explanation for public opinion towards the jurisdiction of international human rights institutions over a nation’s armed forces using national survey data.