Systematic differences in electropherogram peak heights reported by different versions of the GeneScan software

DNA profiling using STRs on the 310 and 3100 Genetic Analyzers routinely generates electropherograms that are analyzed with the GeneScan software available from the instrument's manufacturer, Applied Biosystems. Users have been able to choose from three different smoothing options that have been known to result in significant differences in the peak heights that are reported. Improvements in the underlying algorithm of the most recent version of the software also result in significant and somewhat predictable differences in peak height values. Laboratories that have performed validation studies using older versions of GeneScan should either reanalyze the data generated in those validation studies with the newest version of the software or otherwise take into consideration the systematically higher peak height values obtained as they begin following the recommendation of the manufacturer and use the new algorithm.     

Contents of Volume 22 (2003)

Volume Contents

Contents of Volume 22 (2003)     

Selection Bias in Comparative Research: The Case of Incomplete Data Sets

Selection bias is an important but often neglected problem incomparative research. While comparative case studies pay someattention to this problem, this is less the case in broadercross-national studies, where this problem may appear throughthe way the data used are generated. The article discusses threeexamples: studies of the success of newly formed political parties,research on protest events, and recent work on ethnic conflict.In all cases the data at hand are likely to be afflicted byselection bias. Failing to take into consideration this problemleads to serious biases in the estimation of simple relationships.Empirical examples illustrate a possible solution (a variationof a Tobit model) to the problems in these cases. The articlealso discusses results of Monte Carlo simulations, illustratingunder what conditions the proposed estimation procedures leadto improved results.     

A Constitution for Antidiscrimination: Exploring the Vanguard Moment of Community Law

It is a commonplace that 'non-discrimination' is a fundamental principle of Community Law. If the principle is taken to express a broader commitment to equality, however, there appears to be something quite unusual about it. When compared with the standards set by modern constitutional law, the commitment to equality is, at least with respect to Member State action, less extensive; in the context of indirect gender discrimination, however, the principle acquires remarkable scope. Although this 'vanguard moment' of Community Law is tacitly acknowledged in the practice of the ECJ, it is, at the same time, subdued; the resources of the principle might be tapped, however, by moving toward a constitution for antidiscrimination. The article explores both the philosophical presuppositions and the institutional context of what could become a constitutionalisation of antidiscrimination at the level of Community Law.     

The microeconomic voter

In the United States, aggregate and individual level studies of economic voting for the Congress have produced contradictory findings. The same is true for models of economic voting for the Australian Parliament. This paper presents data taken from a series of individual level studies which show that voters' attitudes towards fiscal and microeconomic issues have been better predictors of the vote for the Australian House of Representatives over the last four elections than their attitudes towards macroeconomic issues. This finding suggests that the cause of the inconsistency between aggregate and individual level models of voting may be that aggregate models of economic voting which include only macroeconomic variables are inadequately specified, since they do not take broader aspects of the economy into account.