Depression and suicidal ideation in early adolescents

This study sought to determine to what extent depression in young adolescents could be predicted by a variety of demographic and personality measures. A sample of 132 adolescents enrolled in junior high school completed a biographical data sheet, short forms of the Beck Depression Inventory (BDI), a Sensation- Seeking Scale (SSS), the Family Environment Scale (FES), a social support index (SSI), and a life stress inventory (LSI). The nondepressed group differed from the depressed group on a variety of variables, and stepwise multiple regression suggested a significant relationship between depression and life stress and an inverse relationship between depression and family cohesion.Received Ph.D. from University of North Dakota. Main research interests are family coping and child psychopathology.Received M.A. from University of Washington. Main research interests are adolescent depression and future self-concept.Received M.A. from University of Washington. Main research interests are Projective assessment of Personality.     

Beyond anxiety and fantasy: The coital experiences of college youth

Counting virgins is described as social bookkeeping, a necessary but not sufficient task for social scientists. More important is the development of an understanding of the social processes which encourage or inhibit coital behavior. The analysis in this paper uses the socialbookkeeping approach to document the relatively stable rates of early and premarital coitus since the Kinsey report. The data are drawn from a 1972 study of 14–18-year-olds and a 1967 study of college students. When appropriate controls for educational attainment and age are introduced, it is shown that, in comparison to the change in rates at the beginning of the century, the rates since the 1940's have increased only a fourth as much. More importantly, coital behavior is shown to be still strongly linked to traditional patterns of restraint and facilitation. Traditional factors, such as relationships with parents and religious attendance, are shown to restrain early coital experience (defined as coitus before age 18), while factors linked to the courtship process such as dating frequency, facilitated this early behavior. During college both restraining and facilitating factors were operative, but levels of coital behavior in most cases stayed surprisingly low. Rates of frequent coitus rarely reached 40% among female college seniors and the proportion of college female seniors with three or more partners never reached 20%. The factors which encourage sexual activity during college are the courtship factorsdating behavior and being in love. In terms of initial coitus, women overwhelmingly report that they were in love with their partner. Given the relative stability of rates of early and premarital coitus and continuity of the role of courtship factors in facilitating this behavior, popular discussions of the contemporary sexual revolution are seen as being out of touch with reality and possibly inducing anxiety among young people when they do not experience the sexual revolution.Data analysis for this paper was carried out under NICHD grant HD 04156 and Illinois Law Enforcement Commission grant 2-09-25-0410-02, and also General Support Grant 5-SO1-RRO-5666-05.Received Ph.D. in Sociology from the University of Chicago. Research interests include post childhood socialization, social change and deviance, and urban social studies.Received Ph.D. in Sociology from the University of Chicago. Main research interests include adolescence, urban social studies, and adult socialization.Received Ph.D. in Sociology from the University of Chicago. Main research interest is social change and deviance.     

Son of joe: Continuity and change among white working class adolescents

The present article focuses upon the much-neglected topic of white working class youth — the children of another other America. Based upon the available literature as well as upon a recent program of ethnographic research, the institutional settings — community, family, school — within which working class youth grow up are examined with particular emphasis on their climate and values. Attention is paid to the heterogeneity contained within this segment of the population pointing to four distinct types: collegians, greasers, hippies, and those encapsulated in family life. The article points to factors that promote a potential increase in residential social class homogeneity that, in turn, promotes class values, social and personal expectations, and modal relationships that increasingly diverge from the norms of an urban-industrial middle class society and that in considerable measure either contribute to a growing conservative alienation from the larger society or make adjustments to that society more problematic for its youth. The emergent picture of white working youth in part resembles that of youth in general, but in a more significant measure is much different from that found in either higher or lower social strata.This research was supported by USPHS-NIH Contract 70-511 and USPHS-NICHD Grant No. 04156.Received Ph.D. in Sociology from the University of Chicago. Research interests include post childhood socialization, social change and deviance, and urban social studies.Received Ph.D. in Sociology from the University of Chicago. Main research interest is social change and deviance.Candidate for Ph.D. in Sociology from Northwestern University. Main research interests are social stratification, youth, and social change in an industrial society.     

Learning to love the state action doctrine

The state action doctrine receives relatively little attention in the Federal Trade Commission/Department of Justice 2004 report on competition in the health care sector. Not surprisingly, the report focuses primarily on urging states to reconsider specific laws that tend to restrict competition in health care markets but that are clearly shielded by the state action doctrine. Relatively little attention is given to the interpretation of the doctrine itself. This article employs the twin themes of institutional choice and market failure to evaluate a number of interpretive proposals affecting the state action doctrine that were available to, but not taken up by, the agencies. It also proposes using the state action doctrine to ease the burden on courts in market-failure cases in which there is an obvious threat to competition and the alternative of publicly accountable regulatory action is available.     

Validation of Large White Pig as an animal model for the study of cannabinoids metabolism: application to the study of THC distribution in tissues

This study presents a new animal model, the Large White Pig, which was tested for studying cannabinoids metabolism. The first step has focused on determination of plasma kinetics after injection of Delta(9)-tetrahydrocannabinol (THC) at different dosages. Seven pigs received THC by intravenous injections (50, 100 or 200 microg/kg). Plasma samples were collected during 48 h. Determination of cannabinoids concentrations were performed by gas chromatography/mass spectrometry. Results showed that plasma kinetics were comparable to those reported in humans. Terminal half-life of elimination was 10.6 h and a volume of distribution of 32 l/kg was calculated. In a second step, this model was used to determine the kinetic profile of cannabinoids distribution in tissues. Eight Large White male pigs received an injection of THC (200 microg/kg). Two pigs were sacrificed 30 min after injection, two others after 2, 6 and 24 h. Different tissues were sampled: liver, kidney, heart, lung, spleen, muscle, fat, bile, blood, vitreous humor and several brain areas. The fastest THC elimination was noted in liver tissue, where it was completely eliminated in 6 h. THC concentrations decreased in brain tissue slower than in blood. The slowest THC elimination was observed for fat tissue, where the molecule was still present at significant concentrations 24 h later. After 30 min, THC concentration in different brain areas was highest in the cerebellum and lowest in the medulla oblongata. THC elimination kinetics noted in kidney, heart, spleen, muscle and lung were comparable with those observed in blood. 11-Hydroxy-THC was only found at high levels in liver. THC-COOH was less than 5 ng/g in most tissues, except in bile, where it increased for 24 h following THC injection. This study confirms, even after a unique administration, the prolonged retention of THC in brain and particularly in fat, which could be at the origin of different phenomena observed for heavy users such as prolonged detection of THC-COOH in urine or cannabis-related flashbacks. Moreover, these results support the interest for this animal model, which could be used in further studies of distribution of cannabinoids in tissues.     

The Progression Towards Ecological Quality Standards

Environmental law still lacks coherence in many respects. Twokey areas of UK and EC law—water pollution control andbiodiversity protection—are examined to see whether itis possible to adopt more common approaches. A key developmentin pollution control law was its redirection in the last twentyyears from a largely reactive instrument towards one embeddedin the realisation of environmental quality objectives throughprecisely stated quality standards. On closer inspection, manyof these standards, though, are anthropocentric in origin. Theapproach of using the law purposively to achieve defined objectivesis much better developed in pollution legislation as comparedto the law on biodiversity protection. The latter area now needsto see a similar development in ecological quality standards,while recognising that their formulation is a significantlydifferent exercise from that of establishing environmental qualitystandards. The use of ecological quality standards in the WaterFramework Directive is commendable, but there remain substantialreservations about the criteria adopted and the underlying basisfor ecological valuation.     

Towards the development of ethical practices in paediatric clinical trials: the special position of the terminally ill child

This article examines the emotive and vexing issue of the involvement of terminally children in paediatric clinical trials. Particular emphasis is placed on the participation of such children in Phase I clinical studies, as such studies do not yield any benefit to the individual child. It provides an historical overview of medical research involving children and examines the moral arguments surrounding the participation of children in clinical trials. The article examines the conflict between doctor-as-researcher and doctor-as-treater as well as the problems presented by proxy consent providers. The role played by the human research ethics committee in this area is examined, as is the regulatory framework established by the National Health and Medical Research Council. The article argues that the participation of terminally ill children in Phase I clinical trials is not morally repugnant provided that there is a total commitment to the protection of the child participant's well-being during the dying process. It is argued that the moral justification for such position derives from the utilitarian notion that participation in such studies aims to benefit future generations of ill children.