大鼠双后肢挤压伤局部肌组织NO变化及其作用

目的探讨大鼠双后肢挤压伤局部肌组织NO含量变化及其在肌组织损伤中的可能作用。方法应用大鼠双后肢挤压伤模型。实验动物随机分为对照(S)组、挤压(C)组、挤压并舌下注射氨基胍(AG)组(A组)、挤压并舌下注射L-精氨酸(L-Arg)组(L组)。用比色法检测局部肌组织和血清NOS活性、NO含量,免疫组化法检测局部肌组织eNOS、iNOS蛋白表达,测量局部肌组织湿干质量比值(W/D),并观察肌组织的组织病理学改变。结果与S组相比,C组双后肢挤压引起局部肌组织明显损伤,肌组织W/D明显升高(P<0.01),肌纤维溶解,血管扩张、淤血、出血、间质水肿等继发性损伤,肌组织中eNOS和iNOS蛋白表达上调,NOS活性增加(P<0.01),NO含量增加(P<0.01);相关分析表明,肌组织W/D与NO含量呈显著正相关,在A组和L组,应用AG和L-Arg分别导致肌损伤(如肌组织W/D)减轻和加重。血清中NOS活性和NO含量变化大致与肌组织类似。结论挤压大鼠双后肢可诱导局部肌组织eNOS和iNOS蛋白表达上调,NOS活性增加,NO生成增多;NO生成增多介导了局部肌组织继发性损伤。     

推荐一部重要的国际法专著——费德罗斯《国际法》

<正> 随着我国国际往来的增加,国际法愈来愈受到有关教学和科研单位以及实际工作部门的重视。在《奥本海国际法》中译本第二次印刷出版之后,人们关切地询问:还有哪些重要的国际法专著翻译出版呢?目前,由商务印书馆组译出版的奥地利著名法学专家阿尔弗勒特·费德罗斯《国际法》已与读者见面。资德罗斯1890年2月生于奥地利因斯布鲁克,1913年毕业于维也纳大学法律系,获得法学博士。起初他担任法官,1918年进入奥地利外交部服务。1921年任维也纳大学国际法讲     

Understanding urban Alevism through its socio-spatial manifestations: cemevis in İzmir

Cemevis emerged as the spaces of the Alevi identity in contemporary cities of Turkey. On the basis of in-depth interviews conducted in ?zmir with the heads of cemevi associations, this study claims that, while cemevis were enforced by the process of urbanization, they have been transforming the Alevi practices and collective organizations and eventually constructing a new type of Alevism as to religious practices, community institutions and collective imagination. Though no legal–political recognition has yet been granted to cemevis as the places of worship, they have established themselves as central institutions of urban Alevis with their extensive use beyond the limited oppositional categorization of culture–religion. This denial of legal status which has been seen as the violation of basic human rights is one of the main constitutive dynamics in the ongoing debates on Turkey's Alevi question. It is to such an extent that the denial of legal status to cemevis has today come to be identified by Alevi groupings with the denial of Alevi collective identity itself.     

以激励机制推动大学生向西部地区流动探究

我国专业技术人才的空点分布很不合理,东部地区人才高度密集,而西部地区则人才严重匮乏。激励大学生到西部地区就业无疑是优化我国人力资源配置,推动西部经济持续快速增长的有效途径。