Fatal intoxication with 1,4-butanediol: Case report and comprehensive review of the literature

A fatal case of 1,4-butanediol (1,4-BD) oral ingestion is reported here, in which a 51-year-old man was found dead in his bed. According to the police report, the deceased was a known drug user. A glass bottle labeled (and later confirmed to be) “Butandiol 1,4” (1,4-BD) was found in the kitchen. Furthermore, the deceased's friend stated that he consumed 1,4-BD on a regular basis. The autopsy and histological examination of postmortem parenchymatous organ specimens did not revealed a clear cause of death. Chemical-toxicological investigations revealed gammahydroxybutyrat (GHB) in body fluids and tissues in the following quantities: femoral blood 390 mg/L, heart blood 420 mg/L, cerebrospinal fluid 420 mg/L, vitreous humor 640 mg/L, urine 1600 mg/L, and head hair 26.7 ng/mg. In addition, 1,4-BD was qualitatively detected in the head hair, urine, stomach contents, and the bottle. No other substances, including alcohol, were detected at pharmacologically relevant concentrations. 1,4-BD is known as precursor substance that is converted in vivo into GHB. In the synoptic assessment of toxicological findings, the police investigations and having excluded other causes of death, a lethal GHB-intoxication following ingestion of 1,4-BD, can be assumed in this case. Fatal intoxications with 1,4-BD have seldom been reported due to a very rapid conversion to GHB and, among other things, non-specific symptoms after ingestion. This case report aims to give an overview to the published of fatal 1,4-BD-intoxications and to discuss the problems associated with detection of 1,4-BD in (postmortem) specimens.     

A Lasting Impact? On the Legislative Activities of Immigrant-origin Parliamentarians in Germany

The article analyses the degree of substantive representation by immigrant-origin MPs in Germany's national and state parliaments. To test the expectation that an immigration background increases the likelihood of engaging with migration-related topics, an analysis is undertaken of all parliamentary questions (PQs) formally asked by immigrant-origin MPs in Germany's national and state parliaments between 1987 and 2009. By controlling for several time-invariant and time-variant factors, the longitudinal analysis confirms that a visible immigration background results in asking more migration-related PQs. While several contextual, party-political and personal (career) factors influence the likelihood of asking such questions in parliament, there is no evidence for a decrease over time. Presence effects are significant and of lasting nature. This means that the parliamentary presence of immigrant-origin MPs with a visible background goes beyond sheer symbolic representation.     

Critical Autopoiesis and the Materiality of Law

Autopoietic theory is increasingly seen as a candidate for a radical theory of law, both in relation to its theoretical credentials and its relevance in terms of new and emerging forms of law. An aspect of the theory that has remained less developed, however, is its material side, and more concretely the theory’s accommodation of bodies, space, objects and their claim to legal agency. The present article reads Luhmann’s theory of autopoietic systems in a radical and material manner, linking it on the one hand to current post-structural theorisations of law and society, and on the other hand extending its ambit to accommodate the influx of material considerations that have been working their way through various other disciplines. The latter comprises both a materialisation of the theory itself and ways of conceptualising the legal system as material through and through. This I do by further developing what I have called Critical Autopoiesis, namely an acentric, topological, post-ecological and posthuman understanding of Luhmann’s theory, that draws on Deleuzian thought, feminist theory, geography, non-representational theory, and new material and object-oriented ontologies. These are combined with some well-rehearsed autopoietic concepts, such as distinction, environment and boundaries; Luhmann’s earlier work on materiality continuum; more recent work on bodies and space; as well as his work on form and medium in relation to art. The article concludes with five suggestions for an understanding of what critical autopoietic materiality might mean for law.     

Ancestry Culture,Assimilation, and Voter Turnout in Two Generations

Political Behavior - Women vote less than men in many parts of the world. Whether this gender gap is due to cultural preferences stemming from traditional gender norms or to structural constraints...     

The Influence of Direct Democracy on Political Interest,Electoral Turnout and Other Forms of Citizens’ Participation in Swiss Municipalities

Based on the data of a survey conducted among Swiss municipalities, this article inquires into the relationship between different institutional settings of local democracy and the amount of political interest of citizens as well as electoral participation and new forms of citizen participation like participatory planning or local agenda 21. The study identifies six distinct settings of local democracy in Switzerland, ranging from pure direct democracy to representative democracy. The analysis shows that the institutional setting of local democracy has no impact on the political interest of the citizens. It also reveals that instruments of direct democracy do not significantly weaken representative democracy as far as electoral participation is concerned. New forms of citizen participation are predominantly used alongside with means of direct democracy.     

Democracy,Regional Security Institutions,and Rivalry Mitigation: Evidence From Europe,South America,and Asia

The fact that democracies maintain peaceful relations with each other is regarded as one of the few law-like correlations in international relations, but the causes of this empirical phenomenon remain contested. This paper tries to fill this theoretical gap by attributing the remarkable stability between democracies to inter-democratic institutions. At the same time, it contributes to the debate on the need to differentiate among international organizations in order to assess their peace-building effects. We identify transnational and trans-governmental linkages as crucial features that distinguish inter-democratic from traditional institutions with non-democratic or mixed membership. In order to explain these institutions’ peace-building effect, we analyze the impact of international institutions on rivalry mitigation with a view to five pairs of states: France-Germany, Greece-Turkey, Argentina-Brazil, Indonesia-Malaysia, and Japan-South Korea. Those dyads all look back at a history of rivalry, conflict, and mutual threat perceptions, and they are located in highly institutionalized regional settings but vary with regard to their political regime type. The controlled comparison of cases demonstrates that the embeddedness of international institutions in transnational and trans-governmental linkages corresponds to each member's regime type and that these institutional differences are responsible for the varying extent of rivalry mitigation.     

Using Bayes’ theorem in behavioural crime linking of serial homicide

Purpose. The study extends research by Santtila et al. (2008) by investigating the effectiveness of linking cases of serial homicide using behavioural patterns of offenders, analysed through Bayesian reasoning. The study also investigates the informative value of individual behavioural variables in the linking process. Methods. Offender behaviour was coded from official documents relating to 116 solved homicide cases belonging to 19 separate series. The basis of the linkage analyses was 92 behaviours coded as present or absent in the case based on investigator observations on the crime scene. We developed a Bayesian method for linking crime cases and judged its accuracy using cross‐validation. We explored the information added by individual behavioural variables, first, by testing if the variable represented purely noise with respect to classification, and second, by excluding variables from the original model, one by one, by choosing the behaviour that had the smallest effect on classification accuracy. Results. The model achieved a classification accuracy of 83.6% whereas chance expectancy was 5.3%. In simulated scenarios of only one and two known cases in a series, the accuracy was 59.0 and 69.2%, respectively. No behavioural variable represented pure noise but the same level of accuracy was achieved by analysing a set of 15, as analysing all 92 variables. Conclusion. The study illustrates the utility of analysing individual behavioural variables through Bayesian reasoning for crime linking. Feasible applied use of the approach is illustrated by the effectiveness of analysing a small set of carefully chosen variables.