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51.
Wong SH Wagner MA Jentzen JM Schur C Bjerke J Gock SB Chang CC 《Journal of forensic sciences》2003,48(6):1406-1415
Pharmacogenomics, applied as an aspect of molecular autopsy, may be used as an adjunct for certifying methadone fatalities. Methadone is metabolized by cytochrome P-450 (CYP) 1A2, 3A4, and 2D6. We hypothesized that methadone toxicity may be partially due to CYP 2D6 *3, *4, and *5 variant alleles, resulting in poor drug metabolism. A retrospective analysis was performed on covariables and risk factors of 21 methadone cases from the Milwaukee County Medical Examiner's Office (1998-2000). PCR genotyping showed: one heterozygous for 2D6*3, two homozygous for 2D6*4, five heterozygous for 2D6*4, and one heterozygous for both 2D6*3 and *4. This limited number of cases showed that the prevalence of poor metabolizer was higher but not significantly different from that of a control group (n = 23) (P > 0.05, Fisher Exact Test). Thus, CYP 2D6 mutations may not yet be directly associated with methadone toxicity. However, pharmacogenomics, complementing other case findings, served as an adjunct in interpreting methadone toxicity of poor and intermediate metabolizers. 相似文献
52.
The combination of photographs taken at two or three wavelengths at and bracketing an absorbance peak indicative of a particular compound can lead to an image with enhanced visualization of the compound. This procedure works best for compounds with absorbance bands that are narrow compared with "average" chromophores. If necessary, the photographs can be taken with different exposure times to ensure that sufficient light from the substrate is detected at all three wavelengths. The combination of images is readily performed if the images are obtained with a digital camera and are then processed using an image processing program. Best results are obtained if linear images at the peak maximum, at a slightly shorter wavelength, and at a slightly longer wavelength are used. However, acceptable results can also be obtained under many conditions if non-linear photographs are used or if only two wavelengths (one of which is at the peak maximum) are combined. These latter conditions are more achievable by many "mid-range" digital cameras. Wavelength selection can either be by controlling the illumination (e.g., by using an alternate light source) or by use of narrow bandpass filters. The technique is illustrated using blood as the target analyte, using bands of light centered at 395, 415, and 435 nm. The extension of the method to detection of blood by fluorescence quenching is also described. 相似文献
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While the concept of power has always been a concern to students of political science and public administration, it has been examined only peripherally in the last few years. Recent work by McClelland has indicated that power may be a very important variable in explaining managerial behavior and organizational effectiveness. Starting with a definition of power provided by McClelland, this paper develops a conceptual framework for analyzing power-related behavior in an organizational setting. The framework is then applied to a problem area of particular interest to the authors--the question of whether or not women managers can be expected to behave differently than their male counterparts because of possible differences in their orientations toward power. We conclude that differences in power needs will not impede the effectiveness of female managers, but women may be at a disadvantage in the work environment due to possible differences in the way they express these needs. 相似文献
55.
AbstractIt is customary to argue that foreign policy is very much dominated by the executive, with parliaments wielding limited influence. However, with the exception of the US Congress, legislative?executive relations in the realm of foreign and security policy have attracted remarkably little scholarly attention. Drawing on a principal?agent framework, this collection scrutinises the conventional wisdom of ‘executive autonomy’ in foreign affairs, indicating that even though parliaments have arguably become more involved in foreign and security policy over time, any notions of parliamentarisation need to be treated with caution. While expectations of consensus in the name of the national interest continue to play an important role in foreign policy decision-making, the papers highlight the role of party-political contestation structuring parliamentary debates and votes in this increasingly politicised issue area. This introductory paper introduces the analytical framework and hypotheses guiding the contributions in this collection, summarises their main findings and suggests avenues for future research. 相似文献
56.
The ability of authoritarian regimes to maintain power hinges, in part, on how well they are able to manipulate the flow of information to the masses. While authoritarian states have had success controlling traditional media, the growth of social media over the last decade has created new challenges for such regimes. The Russian experience offers an example of how an authoritarian regime responds to this potential threat. Because of the massive demonstrations surrounding the 2011–2012 Duma elections, the ruling Russian government suspected that social media provided a significant impetus for the demonstrations. Social media, through its dissemination of opposition blogs, could have helped drive negative attitudes about the governing party. As such, the government responded by employing strategies to tighten their grip on the digital flow of information. We use survey data to demonstrate that exposure to blogs via social media at the time of the demonstrations led many to believe that the elections were fraudulent. Ultimately, we contend that Russian fears concerning the importance of social media for the fomenting of opposition movements is well grounded. Social media can drive support for opposition in an autocratic state. 相似文献
57.
Citizens have always had an important role in the crime control process; they are most often responsible for the detection
of crime. It is imperative, therefore, that citizens perceive police officers to be competent and just in the execution of
their duties; in the absence of such confidence, the process suffers. Ironically, the groups which are most often the victims
of crime hold the most negative attitudes toward the police. Minorities in urban communities, particularly blacks, fit this
pattern. These attitudes appear to be linked to the perception of negative, differential experiences with the police, experiences
which often lead to the filing of a formal complaint. Using a data set from the complaint files of a large American city,
this article explores the relationship between the attitudes of blacks toward the police, experiences with the police, and
complaints lodged against the police. 相似文献
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This article examines the impact of one- and two-officer patrol units on police-citizen interactions which resulted in the filing of citizen complaints against the officer(s). Specifically, it is hypothesized that there is no difference between one- and two-officer units (1) in the rate of injuries to officers in hostile police-citizen interactions, (2) in the number of citizen complainant injuries received in such interactions, (3) in the number of resisting arrest-type charges placed against the citizen, and (4) in the type of charge placed against the citizen in the incident. The data indicate that the impact of staffing is felr more by citizens than officers. When controlling for shift and dangerousness of precinct of occurrence, citizens were found to be more likely to be injured in hostile police-citizen encounters than the police, especially when two officers were present. Officers in two-officer units were more likely to arrest the citizen in the incident which precipitated the complaint and the arrest of that citizen was most likely to be for the more serious charge of assaulting an officer. The results suggest that lone officers resolve more disputes without resorting to formal outcomes. The implications of these findings for police patrol strategy are discussed. 相似文献