Enduring,ephemeral and emerging issues in public administration in Canada: Trends in Canadian Public Administration over fifty years (1958–2007)

Abstract: This issue of Canadian Public Administration marks two landmarks. It is the 50th anniversary issue of the Journal, and it is the last issue to be published by the Institute of Public Administration of Canada. For this issue, we have not produced a “special issue” in the sense of commissioning particular articles. Instead, we have brought together a number of articles that were already in the “pipeline” but that the editors thought made a particular contribution to public administration in Canada. This introductory article, or editor's review, is a retrospective analysis of the content of the Journal. It would appear that while there has been a slight shift towards public policy and a greater concern with provincial and local administration, cpa has maintained an enduring interest in its core areas of administrative theory and political and legal institutions. The content is also compared with findings of the content of other journals and also other analyses of cpa . This review is followed by commentaries by former editors and associate editors on their experiences with the Journal.     

Orphan drug incentives in the pharmacogenomic context: policy responses in the US and Canada

Advances in pharmacogenomic research and increasing industry interest in personalized medicine have important implications for the way that orphan drug policies are interpreted and applied. Concerns have been raised about the potential impact of pharmacogenomics and new genomic technologies on our understanding of how disease categories are delineated, and subsequently, how the concept of rare disease should be defined for the purposes of orphan drug policies. This article considers whether orphan drug legislation can be drafted in a way that will maximize benefits and minimize concerns relating to the impact of pharmacogenomics on orphan drug research and development. After reviewing the issues that may arise at the intersection of orphan drug policies and pharmacogenomics, this article will discuss the potential impact of pharmacogenomics at two critical points: orphan designation and approval of the drug product. At each of these points, the relevant aspects of current US orphan drug legislation are examined, focusing on the extent to which recent amendments may address concerns that have been raised previously. This analysis will then provide the foundation for a critical review and recommendations regarding the proposed new Canadian orphan drug framework.     

What’s left out and why? Informal provisions in formal international law

When states face an international cooperation problem requiring enforcement, when do they decide to make that enforcement formal versus informal? I introduce a research design for investigating how informal mechanisms might be relevant to formal international agreements. I present an overall theory of punishment provisions and a set of hypotheses about whether any needed punishments will be formalized or not. This theory gives rise to a two-part empirical analysis conducted on a large-n dataset. First, the presence of enforcement mechanisms in agreements is predicted, and, second, those cases that are “misclassified”—ones in which the model predicts the presence of such mechanisms, but the agreements lack them—are analyzed. These misclassified agreements, candidates for informal enforcement, are characterized by regime heterogeneity and military asymmetries among parties. Case study evidence supports the results.     

America’s Missing Leverage in Afghanistan and Pakistan: a structural analysis

Abstract

Despite strong shared interests and their dependence on US assistance, Kabul and Islamabad frequently fail to cooperate with the USA’s post-9/11 security agenda. Why doesn’t the USA have more leverage in these alliances and what can it change to be more influential? This article identifies four structural factors in Washington’s alliances in Afghanistan and Pakistan (‘Af-Pak’) contributing to Washington’s lack of coercive power: 1) the USA’s interest makes coercion difficult; 2) Kabul and Islamabad have more invested and will bargain to protect their interests; 3) the form of US commitment (an intense but explicitly temporary military commitment) produces incentives for Kabul and Islamabad to adopt short-term solutions, frequently running against US interests; and 4) the tenets of counterinsurgency policy cause Washington to be politically dependent on Kabul and Islamabad, effectively reducing its influence.