Determination of GHB in urine and serum by LC/MS using a simple one-step derivative

A sensitive and specific method for the determination of gamma-hydroxybutyric acid (GHB) in urine and serum is described. Prior to quantification by LC/MS in a Pauli-type ion trap, the molecule is converted by a fast and simple one-step procedure into its n-butyl ester derivative. Hexa-deutero GHB has been used as internal standard.     

Prime Minister Yitzhak Rabin against the Settlers: A Stakeholder Analysis

This case study considers how a minority stakeholder group of Israeli settlers blocked Prime Minister Yitzhak Rabin's peace initiatives. Drawing on interviews with those who served in Rabin's administration and with the settlers' leaders, this article contends that the prime minister's use of adversarial public rhetoric against the settlers denied the legitimacy of an influential stakeholder group, triggering a backlash of intense militancy from the right-wing minority. This, coupled with Rabin's failure to deal with opposing coalitions, diminished his capacity to implement "land for peace" initiatives. The case illustrates a leader's failure to maintain adequate forms of engagement with key stakeholders. The accompanying analysis demonstrates that stakeholder theories, though incomplete in their existing forms, can still illuminate the high risk and ineffectiveness of denying the legitimacy of stakeholder groups and the strategic importance of maintaining channels of flexible negotiation and cooperation with seemingly marginal groups when high-stakes rivalries are likely to ensue.     

Intra-Party Support for the Good Friday Agreement in the Ulster Unionist Party

Party organisations are often 'black boxes' overlooked by scholars in favour of party leaders, manifestos and elections. Yet intra-party dynamics are often crucial. This article uses the example of the Ulster Unionist Party (UUP) to illustrate this. Events in the 1998–2003 period highlight the importance of splits within the party's governing Ulster Unionist Council (UUC) over the Good Friday Agreement (GFA) which underpins the Northern Ireland peace process. This article pioneers the use of postcode-profiling technology and uses multi-level analysis of a UUC party list to show that delegates' party section provides the best predictor of their stance towards the Good Friday Agreement. Consequently, the article argues that delegate voting behaviour within the UUC is best explained by reference to highly embedded, meso-level institutions which perpetuate networks and condition individual preferences.     

Quantitative and qualitative analysis of DNA extracted from postmortem muscle tissues

DNA extracted from 33 postmortem muscle specimens was analyzed using MZ 1.3, a hypervariable minisatellite probe, as well as locus-specific minisatellite probes (g3, MS1 and MS43). After storage at -25 degrees C for 10 months, DNA from all the samples was partially (approximately 21% of total DNA) degraded even when autopsy was performed 1 day postmortem. However, more than 90% of DNA samples up to at least 3 days postmortem were suitable to obtain good restriction fragment length polymorphism (RFLP) patterns. When small strips of specimen were stored for 8 days at room temperature in moist chambers, approximately 42% of total DNA was degraded. Only 30% of these DNA samples still showed good RFLP patterns. However, no obvious relation between qualities of DNA analyzed by detection of RFLP and quantities of total and high-MW DNA became apparent. A case of familial relationship was ascertained by DNA fingerprints. Since DNA of good quality can be recovered from muscle tissues in large quantities, DNA extraction from muscle tissues and detection of RFLP patterns should be very useful for individual identification in autopsy cases.     

Whither American Jewry?

a former Book Review Editor of Society Magazine.His most recent book is American Aliya: Portrait of an Innovative Migration Movement.     

More than Pathological Formalization: Understanding Organizational Structure and Red Tape

Most research has conceptualized red tape as being a pathological subset of organizational formalization. This article argues that focusing on a single dimension of organizational structure as a red tape driver is unrealistically narrow. Specifically, the article advances hypotheses as to how organizational centralization and hierarchy affect perceived red tape, in addition to formalization. This reasoning is tested using survey data from employees of three local government organizations in the southeastern United States. All three hypotheses are supported: higher levels of organizational formalization, centralization, and hierarchy are associated with more red tape. Open‐ended comments also indicate that red tape is not solely perceived as related to formalization. The findings imply that red tape is a multifaceted perception of organizational structure rather than perceived pathological formalization.     

Imprinting and the progeny of university spin-offs

In this paper, we employ a genealogical imprinting approach to theorize that experiences incurred during the founding of a first-generation university spin-off will influence future spin-off activity from the focal firm. We propose that firms that secure equity investment during their founding process will have a higher likelihood of generating subsequent spin-offs, and that this impact is conditional on the human capital of the founding team. We test our hypotheses on a sample of 101 first generation university spin-offs around a large US research university and their subsequent progeny firms. This study develops a new understanding of multi-generational spin-off processes in a region.