Chemical profiling of heroin recovered from the North Korean merchant vessel Pong Su

Heroin samples, seized from the North Korean merchant vessel Pong Su in Australian waters, were analyzed to determine geographic origin. Duplicate samples were analyzed by the National Measurement Institute's Australian Forensic Drug Laboratory and the United States Drug Enforcement Administration's Special Testing and Research Laboratory. Alkaloid ratios were determined by both liquid chromatography-diode array detection (LC-DAD) and capillary electrophoresis-diode array detection (CE-DAD) techniques. Acid/neutral manufacturing by-products were determined by solvent extraction followed by gas chromatography-mass spectrometry (GC-MS). Solvents, trapped in the heroin particles during manufacture, were detected by both static headspace GC-MS and purge and trap GC-MS. The alkaloid ratios obtained were consistent with heroin of a Southeast Asian (SEA) origin and principal component analysis of the alkaloid results demonstrated the presence of at least four subgroupings within the seizure. The solvent analysis detected diethyl ether and ethyl acetate, solvents typically seen in SEA heroin. However, the acid/neutral analysis revealed compounds not normally seen in heroin of a SEA origin. Furthermore, sterol-like molecules, always detected in the acid/neutral analysis of SEA heroin, were absent from the Pong Su samples. The Pong Su heroin, although similar to SEA heroin, has sufficient differences to classify it as having an unknown origin at the time of this writing.     

Asphyxia by tracheobronchial thrombus

Asphyxia secondary to airway obstruction has numerous underlying causes, both acute and chronic. Causes of chronic airway obstruction, such as neoplasms and tracheal scarring, are often clinically apparent well prior to asphyxia. Causes of acute airway obstruction may not be as obvious to clinicians or investigators. These include infections, anaphylactic reactions, status asthmaticus, inhalational injuries, and aspirations, which may result in acute obstruction and sudden death.We report the deaths of 2 individuals, a 43-year-old female and a 78-year-old female, both with adenocarcinoma. The 43-year-old was hospitalized with a stage III, poorly differentiated infiltrating ductal carcinoma of the breast metastatic to the lymph nodes. She was intubated to treat poor respiratory function and acidosis. A bronchoalveolar lavage was consistent with alveolar hemorrhage; no organisms were identified. Blood and "clot" were in her endotracheal tube, so the endotracheal tube was replaced. She became comatose and life support was withdrawn. At autopsy, a large red-gray thrombus obstructed the trachea and extended into the right bronchus. Microscopically, the entire clot was composed of fibrin, red blood cells, and some mucus. Findings of acute respiratory distress syndrome with hyaline membranes were identified. The cause of death was listed as acute respiratory distress syndrome with tracheobronchial thrombus. Experiencing a decline in mental status, the 78-year-old had metastatic adenocarcinoma of unknown primary. She developed sudden respiratory distress and an airway obstruction was discovered. After failure to relieve the obstruction, she decompensated and died. At autopsy, a large, red-gray thrombus obstructed the distal trachea and both bronchi. Microscopically, the thrombus was composed of fibrin, platelets, and red blood cells. The cause of death was asphyxia secondary to airway obstruction by thrombus. We present these 2 unusual cases of asphyxia and review of the literature focusing on asphyxia and the etiology of airway thrombi.     

Vertebral artery laceration mimicking elder abuse

Elder abuse was first described almost 30 years ago. Today, approximately 1 in 25 elders is abused each year in the United States. A newly described form of domestic violence, the incidence of elder abuse will surely increase as the elderly population grows. Physical abuse/inflicted trauma is generally considered the most extreme form of elder mistreatment and includes blunt trauma, sexual assault, traumatic alopecia, and burns. Elder homicide is usually due to gunshot wounds, blunt trauma, stab wounds, or asphyxia. However, the difficult aspect of assessing the possible elder abuse homicide victim is delineating such inflicted trauma from accidental trauma. We report the case of a 94-year-old "demented" male, who reportedly fell out of his wheelchair. He was transported to a local emergency room, where he became unresponsive during examination. He experienced respiratory distress and was pronounced dead shortly thereafter. At autopsy, he had periorbital contusions and a midline abrasion between the eyes, with underlying supraorbital contusion. The skull, brain, and spinal cord were unremarkable for signs of trauma. The major traumatic finding was in the neck region. Neck dissection revealed hemorrhage extending from the base of the skull to the level of T-1 and anteriorly about the soft tissues, strap muscles, and vasculature. The strap muscles were individually examined and were free of hemorrhage. The carotid arteries and jugular veins were unremarkable. The larynx, hyoid, and thyroid were intact, with only surrounding hemorrhage. Further examination revealed a horizontal fracture of the C5 vertebral body and a medial laceration of the left vertebral artery at the C5 level; subarachnoid hemorrhage was absent. What initially appeared to be trauma to the neck, worrisome for strangulation or blunt force trauma, was a large retropharyngeal hematoma from the left vertebral artery laceration. Traumatic rupture of the vertebral artery usually occurs at the C1 and C2 levels, with resultant subarachnoid hemorrhage. This is an especially vulnerable location since it is where the artery turns and then enters the skull. Associated injuries include spinal cord transection or contusion, brachial plexus injury, pharyngoesophageal injury, and vertebral fractures. Retropharyngeal hemorrhage may result from deep neck infection, tumor, and trauma. Hemorrhage associated with trauma often involves flexion of the cervical spine, followed by hyperextension. The accumulation of blood slowly impinges on the pharynx/larynx and vasculature structures. The exact injuries and etiology of the hemorrhage must be determined to distinguish strangulation from blunt force trauma. The presentation of signs and symptoms can be helpful in assessing the decedent; however, in the practice of forensic pathology such a history is more often lacking.     

The management and administration of parastatal organizations for the promotion of indigenous enterprise: A West African Experience

Among the various functional types of public corporation and statutory authority, those concerned with the regulation and provision of economic opportunities and social amenities constitute one of the most interesting developments in West Africa's parastatal sector today. Taking as a case study the recent initiatives of the Ghana Government ta promote indigenous enterprise (which have had an important demonstration effect on neighbouring Nigeria), the article analyses the performance of parastatal organizations that have been instrumental in fulfilling public policy objectives in this area. It examines first the management objectives established by the guiding legislation, secondly the corresponding choice of organizational structure, and finally the ways in which parastatal managers therein endeavour to implement the tasks of redistributing opportunities between foreign and indigenous private enterprise. Particular emphasis is placed on the innovative roles played by public officials and their organizations in mediating between government and the two segments of the private sector (foreign and indigenous). This includes especially the organization for disinvestment and the management of access to opportunities thereby created: identification of affected business and evaluation of their assets, provision of information for applicants, determination of rules of eligibility for the channelling of demand, supervision of purchase, transfer of management and labour relations during the period of negotiation and transfer. Finally, the article considers the effectiveness of resources use by recipients of enterprises, including patterns of distribution amongst the latter, in order to determine the impact of parastatal organization procedures on policy outcomes.     

Radical Criminals in the Grey Area: A Comparative Study of Mexican Religious Drug Cartels and Australian Outlaw Motorcycle Gangs

This article defines and assesses the ideal-type of the radical criminal as the analytical framework for a comparative qualitative study of Mexican religious drug cartels and Australian outlaw motorcycle gangs and concludes that radical criminals operate in both weak and failed states and stable democracies. The article participates in the wider discussion concerning the existence (and the features) of a grey area between criminal and political violence, through the lens of the radical criminal ideal-type.     

The Influence of Amicus Curiae Briefs on U.S. Supreme Court Opinion Content

We address fundamental questions about the ability of interest groups to shape public policy by examining the influence of amicus curiae briefs on U.S. Supreme Court majority opinion content. We argue that the justices will incorporate language from amicus briefs into their opinions based on the extent to which the amicus briefs contribute to their ability to make effective law and policy. Using plagiarism detection software and other forms of computer assisted content analysis, we find that the justices adopt language from amicus briefs based primarily on the quality of the brief's argument, the level of repetition in the brief, the ideological position advocated in the brief, and the identity of the amicus. These results add fresh insight into how interest groups influence the development of federal law by the Supreme Court.     

Mothers,Maidens and the Myth of Origins in the Irish Constitution

This article examines the ``hidden' ideological appeal which the 1937 Irish Constitution attempted to make by the invocation of the rural ideal, a hybrid of Irish nationalism, Catholicism and, most importantly, Gaelic romanticism. In this move, the historical legitimacy of the new state could be defined through the constitution by an appropriation of diverse symbols from an imagined past, a golden age of Gaelic unity and moral certainties. Particular attention will be paid to the image of woman as a representation of the nation in the 1937 Constitution, and to the context of Irish nationalist discourse generally, where she repeatedly appears in the archetypal forms of either mother or virgin. The predominance of the image of woman as mother in the Constitution, in contrast to her appearance in pre-independence nationalist discourse (where she regularly figured as a combination of mother, helpless maiden, seductress and destroyer) will be examined in terms of the Lacanian themes of Lack and jouissance (or enjoyment). This cultural (and legal) shift will be examined in terms of the renunciation of enjoyment inherent in this new national imagery, and in relation to the redemptive potential of the image of woman as mother; themes which appear significant in relation to post-colonial political formations generally, and to post-independence Irish political discourse in particular.