Estimating Individual Contributions to Complex DNA SNP Mixtures.,

High‐throughput sequencing (HTS) of large panels of single nucleotide polymorphisms (SNPs) provides an alternative or complimentary approach to short tandem repeats (STRs) panels for the analysis of complex DNA mixture forensic samples. For STRs, methods to estimate individual contribution concentrations compare capillary electrophoresis peak heights, peak areas, or HTS allele read counts within a mixture. This article introduces three approaches (mean, median, and slope methods) for estimating individual DNA contributions to forensic mixtures for HTS/massively parallel sequencing (MPS) SNP panels. For SNPs, the major:minor allele ratios or counts, unique to each contributor, were compared to estimate contributor proportion within the mixture using the mean, median, and slope intercept for these alleles. The estimates for these three methods were typically within 5% of planned experimental contributions for defined mixtures.     

Bottom-level organizational changes within entrepreneurial and engaged models of university: insights from Italy

We analyze the way in which individual academics and research groups organize their third mission activities before and after the institutionalization of third mission strategies by the university governing body. Drawing on the literature, we put forward an interpretative framework that links central entrepreneurial or engaged strategies with the way academics organize their third mission activities. Then, we propose an application of this frame to the case of the University of Florence (Italy), before and after its transition to more structured entrepreneurial and engaged models. We use a mix of quantitative and qualitative analysis. A cluster analysis allows identifying different types of academics involved in the third mission based on the way they organize their activities. Furthermore, a set of interviews to academics complements the comparison and the interpretation of the clusters obtained. The following paths of change emerge: (1) increased proportion of academics involved in third mission activities; (2) bottom-level initiatives that are aligned with central strategies; and (3) increased heterogeneity of bottom-level organization forms, with a relative loss of importance of the group dimension with respect to the individual academics and an increased specialization of research groups.

     

Containing Environmentalism: Risk,Rationality, and Value in the Wake of the Exxon Valdez

This article revisits regulatory debates about environmental valuation following the Exxon Valdez oil spill to argue that the spill can be seen as a constitutive moment in the rise of neoliberalism. I show that rationalizing environmental values was not simply about applying market rationality to the natural world, but entailed reexamining the nature of that rationality itself and its relevance to social behavior. I then trace the reverberations of these debates beyond the realm of environmental policy, highlighting an underappreciated legacy of the Valdez: the first credit default swap, executed in response to an unprecedented punitive fine leveled against Exxon. Illuminating the linked histories of environmental valuation, corporate environmentalism, and financialization through that event, I argue that environmental valuation is a political problem through which neoliberal strategies for the governance of life (both human and nonhuman) have been forged.     

Advancing the study of political cleavages through experimentation: Revisiting regionalism and redistributive preferences in Canada

The maintenance of welfare state policies requires citizen support for the provision of a social safety net through taxation and redistribution. Research has shown that a diverse political polity presents a risk to the welfare state; however, Canada bucks the trend and does not see citizen support for economic redistribution decline in response to immigration-based population diversity. Using Canada as our case, we argue that scholars of welfare state politics and redistribution should turn their attention to other sources of population heterogeneity in an effort to better understand how different political cleavages affect citizens’ redistributive preferences. We use an online experimental survey to manipulate the in-group identity of 500 Canadians. The survey enables respondents to identify with other in-group identities along regional, linguistic, income-group, and urban/rural characteristics. Our results find that while Canadians do have a strong baseline preference for redistributive behaviour, regional and linguistic cleavages moderate this outcome.     

Whole-person health and development: two South Indian initiatives

ABSTRACT

In responding to the 2016 reformulation of the United Nation’s Sustainable Development Goals, the development community’s efforts are focused on a sweep of initiatives aiming to promote whole-society, sustainable development. The ambition of the SDGs is inspiring, but also daunting, and does not always sit easily within national models of economic development. This viewpoint profiles two organisations in the south Indian state of Tamil Nadu, that have decades of experience in whole-person development among scheduled tribes and disability communities. Both organisations serve as timely examples of ongoing holistic, whole-person health and development in the context of new ideals and economic realities.     

External Pressures and Internal Dynamics in the Institutionalization of Performance-Based Budgeting: An Endless Process?

The well-known practice of performance-based budgeting (PBB) is a relevant component of the New Public Management (NPM) reform agenda and has become widespread, with varying approaches and results across countries. However, its variation within specific countries has remained largely unexplored. This study analyzes three organizations operating within the same context—three ministries in Italy—to contribute to a new understanding of PBB variation by illustrating why the same PBB practice can or cannot be implemented and internalized similarly across these organizations and thus become (or not) fully institutionalized. The study adopts and enriches the institutional approach by extending beyond isomorphic convergence toward PBB and explaining practice variation, linking the interactions between external pressures and internal dynamics at the organizational level to PBB institutionalization. The empirical analysis shows how a lack of alignment between external pressures and internal dynamics contributes to an unfinished and apparently endless process of institutionalization.     

An assessment of sexual health risk behaviors among female youth in juvenile detention

This study investigated the association between risky sexual behavior and drug use among female youth sentenced to a regional juvenile detention center. Preincarceration behavioral health risk data were collected from a modified version of the Youth Risk Behaviors Surveillance Survey completed by respondents. Almost all of the 105 participants had been detained before their current sentence, more than half of them were sexually active before the age of 13, and 70% had smoked marijuana or drank alcohol by age 14. A regression analysis was conducted to determine if preincarceration sexual health risk behaviors were significant enough to predict continued risk behaviors related to pregnancy, disease prevention, and substance use. Findings indicate that youth detention-based prevention programs should emphasize sexual and drug-risk reduction strategies as a means to reduce risky behaviors for this population.