Mobilizing the Public Against the President: Congress and the Political Costs of Unilateral Action

Prior scholarship overlooks the capacity of other actors to raise the political costs of unilateral action by turning public opinion against the president. Through a series of five experiments embedded in nationally representative surveys, we demonstrate Congress's ability to erode support for unilateral actions by raising both constitutional and policy‐based objections to the exercise of unilateral power. Congressional challenges to the unilateral president diminish support for executive action across a range of policy areas in both the foreign and domestic realm and are particularly influential when they explicitly argue that presidents are treading on congressional prerogatives. We also find evidence that constitutional challenges are more effective when levied by members of Congress than by other actors. The results resolve a debate in the literature and suggest a mechanism through which Congress might exercise a constraint on the president, even when it is unable to check him legislatively.     

Comparative investigations on the uptake of basic substances into the human keratinocyte cell line HaCaT--a model for the uptake of xenobiotics into the keratinocytes of the hair follicle

The human cell line HaCaT was used to study drug uptake by keratinocytes as an in-vitro model to elucidate drug incorporation into anagen hair follicle. The basic drugs under investigation were taken up very rapidly resulting in a concentration plateau in the keratinocytes which was dependent on the drug concentration in the cell culture medium. The results obtained for HaCaT clearly demonstrated the existence of a partition-equilibrium between the extracellular and intracellular drug concentrations. Only small amounts of the offered drugs were taken up and remarkable differences were observed showing a decreasing uptake for imipramine > haloperidol > cocaine/benzoylecgonine. Total protein content in the culture medium was 3.5 +/- 0.3 mg/mL and the protein binding of the drugs to the foetal serum proteins was found to be negligible in the experiments. Overall, the in vitro findings were consistent with previous observations for in vivo drug incorporation into hair. In particular, an explanation was found for the correlation between the AUC-value and hair concentration observed in animal studies as well as for the generally low drug concentrations in non-pigmented hair.     

The Legal Travails of Kind-Hearted Gunmen

Books reviewed in this article:
Sean D. Murphy, Humanitarian Intervention: The United Nations in anEvolving World Order     

Violence against Women and Femicide: an analysis on the murders of foreign women in Italy

Crime, Law and Social Change - This paper presents the results of a research on the representations of femicide in the judicial field, in Italy. The use of the term femicide is analysed through the...