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61.
Darrell O. Ricke Ph.D. Philip Fremont‐Smith M.S. James Watkins B.S. Sara Stankiewicz M.S. Tara Boettcher B.S. Eric Schwoebel Ph.D. 《Journal of forensic sciences》2019,64(5):1468-1474
High‐throughput sequencing (HTS) of large panels of single nucleotide polymorphisms (SNPs) provides an alternative or complimentary approach to short tandem repeats (STRs) panels for the analysis of complex DNA mixture forensic samples. For STRs, methods to estimate individual contribution concentrations compare capillary electrophoresis peak heights, peak areas, or HTS allele read counts within a mixture. This article introduces three approaches (mean, median, and slope methods) for estimating individual DNA contributions to forensic mixtures for HTS/massively parallel sequencing (MPS) SNP panels. For SNPs, the major:minor allele ratios or counts, unique to each contributor, were compared to estimate contributor proportion within the mixture using the mean, median, and slope intercept for these alleles. The estimates for these three methods were typically within 5% of planned experimental contributions for defined mixtures. 相似文献
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In “J.M. Keynes and the Personal Politics of Reparations,” Parts I and II, published in Diplomacy and Statecraft (2014), the American historian Stephen Schuker claims that Keynes’ scientific arguments against the policy of reparations were distorted by both political passion and his emotional attachment to the German banker, Dr. Carl Melchior. He provides no evidence for this argument, and Keynes’ analytic positions emerges without reference to either. 相似文献
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In recent years controversy has arisen over whether the rate of women's gun ownership has increased over time. While media reports claimed a rising trend in women's gun ownership, existing scholarly studies found stable rates over time. This paper investigates the issue using the 1973–2002 General Social Survey data. Our bivariate analysis reveals a declining trend in female gun ownership, especially in recent years. The logistic regression results indicate that holding relevant variables constant, the probability of female gun ownership decreases over time. Comparisons are also made with men. Similar results for male gun ownership are obtained. Possible explanations and implications of findings are discussed. 相似文献
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Philip Longworth 《The Journal of peasant studies》2013,40(2):183-205
This paper examines the leadership of the Pugachev revolt, the vast peasant uprising which took place in Russia between 1773 and 1775. It is also concerned with certain general issues, particularly those concerning the raising and subsequent sustaining of large‐scale peasant movements in ‘pre‐industrial’ societies where peasant organisations beyond village level are lacking. The Pugachev revolt had peculiarities which are of intrinsic interest, but it also provides significant parallels and contrasts to other peasant uprisings (not only in seventeenth‐ and eighteenth‐century Russia) and generally serves to highlight the problems of the articulation of rural protest in backward societies. 相似文献
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Research into e-government is relatively new. Nevertheless, much contemporary thinking and writing about e-government is driven by normative models that appeared less than a decade ago. The authors present empirical evidence from three surveys of local e-government in the United States to test whether these models are accurate or useful for understanding the actual development of e-government. They find that local e-government is mainly informational, with a few transactions but virtually no indication of the high-level functions predicted in the models. Thus, the models do not accurately describe or predict the development of e-government, at least among American local governments. These models, though intellectually interesting, are purely speculative, having been developed without linkage to the literature about information technology and government. The authors offer grounded observations about e-government that will useful to scholars and practitioners alike. 相似文献
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Results from previous studies of campaign spending imply that equal-sized grants to both incumbents and challengers are a net benefit to challengers, who on average spend less money and derive greater marginal returns from each additional dollar. This study provides an experimental test of this proposition. Cities holding mayoral elections in November 2005 and 2006 were randomly assigned to broadcast nonpartisan radio ads that stated the names of the mayoral candidates, reminded listeners about the date of the upcoming election, and encouraged them to vote. Consistent with the findings of previous studies on the differential effects of incumbent and challenger campaign spending on election outcomes, we find that these radio ads produced substantially more competitive elections. The borderline statistical significance of our results, however, invites replication of this experiment. 相似文献