Allele frequencies of 13 short tandem repeat (STR) loci in the Romanian population

A population study on 13 tetra- and pentameric STR loci (D3S1358, VWA, D8S1179, D21S11, D18S51, D16S539, D2S1338, D19S433, THO1, FGA, ACTBP2 (SE33), Penta D and Penta E) was performed with Romanians from the Bucharest area.     

Determination of several psychiatric drugs in whole blood using capillary gas-liquid chromatography with nitrogen phosphorus detection: comparison of two solid phase extraction procedures

A simple and reliable gas chromatographic method with nitrogen-phosphorus detection without derivatization was developed for the detection of several psychiatric drugs in whole blood as part of systematic toxicological analyses (STA). Drugs included mirtazapine, chlorpromazine, methotrimeprazine (levomepromazine), clothiapine, olanzapine, clozapine, haloperidol, and thioridazine. All drugs were studied at concentrations of 100-2,000 microg/L, except haloperidol that was studied at concentrations of 400-8,000 microg/L. In order to select the best blood purification procedure and therefore increase the signal to noise ratio we have compared two solid-phase extraction (SPE) columns, Chem Elut and Bond Elut Certify, for their recovery, precision, sensitivity and matrix purification efficiency. Recoveries for these drugs using Chem Elut columns at 500 and 2,000 microg/L (2,000 and 8,000 microg/L for haloperidol) were in the range 21-65%, with intra-assay and inter-assay precisions of less than 17% and 19%, respectively. Limits of detection (LODs) and limits of quantitation (LOQs) for mirtazapine, chlorpromazine, methotrimeprazine, clothiapine, olanzapine, clozapine, and thioridazine ranged from 62 to 161 microg/L and from 205 to 531 microg/L, respectively. LOD and LOQ for haloperidol were 442 and 1,458 microg/L, respectively. Recoveries of these compounds using Bond Elut Certify columns at 500 and 2,000 microg/L (2,000 and 8,000 microg/L for haloperidol) were in the range 44-97%, with intra-assay and inter-assay precisions of less than 7% and 14%, respectively. LODs and LOQs for mirtazapine, chlorpromazine, methotrimeprazine, clothiapine, olanzapine, clozapine, and thioridazine ranged from 37 to 66 microg/L and from 122 to 218 microg/L, respectively. LOD and LOQ for haloperidol were 156 and 515 microg/L, respectively. Linearity was observed in the studied range for all compounds with r(2) values of >0.999. The use of the mixed-mode bonded-silica Bond Elut Certify columns showed advantages comparing with Chem Elut columns for the screening of these psychotropic agents such as higher recoveries, cleaner extracts, better sensitivity, better precision and less solvent consumption and subsequent disposal.     

Consumer Preference for Neotraditional Neighborhood Characteristics

Abstract

Much research on residential mobility relies on examining people's choices within the context of what is available in a local housing market. However, it is difficult to determine the demand for alternative housing or neighborhood types that may not be available or are available only in limited quantities. Hence, the market may not accurately reveal consumer preferences for such alternatives.

We estimate a discrete choice model of neighborhood choice by using data from a choice‐based conjoint analysis survey that allows us to vary characteristics experimentally. The model is used to determine consumer preferences for neotraditional neighborhood design features, including neighborhood layout, housing density, surrounding open space, and commuting time, while holding other characteristics, including school quality and neighborhood safety, constant. The results indicate that the neotraditional design with higher density is less preferred on average, but that niche marketing, additional open space, or other amenities can overcome its negative effects.     

From a Counter-Society to a Counter-State Movement: Jemaah Islamiyah According to PUPJI

The General Guide for the Struggle of Al-Jama’ah Al-Islamiyah (Pedoman Umum Perjuangan Al-Jama’ah Al-Islamiyah)—commonly known under its acronym PUPJI—is an essential document for understanding Southeast Asia's most deadly terror network. Issued by Jemaah Islamiyah's Central Executive Council (Qiyadah Markaziyah), it outlines the group's administrative structure and guiding religious principles, in addition to providing insights into its organizational development, membership recruitment, and operational strategy. From the time Jemaah Islamiyah was established on 1 January 1993—as the result of an internal split within the Darul Islam (DI) movement—until the time it first engaged in terrorist activities—with the Medan church bombings on 28 May 2000—the group was structured and managed in accordance with this handbook. To understand Jemaah Islamiyah, therefore, one must understand PUPJI. ¹ 1. A copy of the original PUPJI document was obtained and translated by the International Center for Political Violence and Terrorism Research (ICPVTR) at the Institute of Defence and Strategic Studies, Nanyang Technological University, Singapore. The author first reviewed and analyzed the document while working as Manager for Research at ICPVTR. The results of this study can be found in Rohan Gunaratna, Elena Pavlova, and Muhammad Hassan Haniff, “A Preliminary Analysis of the General Guide For the Struggle of Jemaah Islamiyah,” ICPVTR, IDSS, February 2004.      

Forecasting the 2010 general election using aggregate local election data

The paper presents a revised method for estimating national vote shares using aggregate data from local government by-elections. The model was originally developed to forecast the annual outcome of local elections but was adapted in time to provide an accurate forecast of Labour’s landslide victory at the 1997 general election. However, over the past decade the changing pattern of party competition which has seen parties becoming more selective about which elections to contest has led to more elections being excluded from the modelling because they failed to meet the exacting criteria that all three major parties, Conservative, Labour and Liberal Democrats, had contested both the by-election and the previous main election, normally held in May. Relaxing these criteria, although increasing the number of available cases would adversely affect the forecast, over- or under-estimating party votes. Instead, the revised method overcomes the problem of differential competition by estimating vote shares for parties that contest one but not both elections. A further innovation is the calculation of a weighted moving quarterly average which takes account of the number of days elapsed between the by-election date and the date of forecast. Using the new method we provide estimates for likely party shares for the 2010 general election.