Breath alcohol concentration determined with a new analyzer using free exhalation predicts almost precisely the arterial blood alcohol concentration

A new breath alcohol (ethanol) analyzer has been developed, which allows free exhalation, standardizes measured exhaled alcohol concentration to fully saturated water vapor at a body temperature of 37 degrees C (43.95 mg/L) and includes a built-in self-calibration system. We evaluated the performance of this instrument by comparing standardized alcohol concentration in freely expired breath (BrAC) with arterial (ABAC) and venous (VBAC) blood alcohol concentrations in fifteen healthy volunteers who drank 0.6 g of alcohol per kg body weight. The precision (coefficient of variation, CV) of the analyzer based on in vivo duplicate measurements in all phases of the alcohol metabolism was 1.7%. The ABAC/BrAC ratio was 2251+/-46 (mean+/-S.D.) in the post-absorptive phase and the mean bias between ABAC and BrAC x 2251 was 0.0035 g/L with 95% limits of agreement of 0.033 and -0.026. The ABAC and BrAC x 2251 were highly correlated (r=0.998, p<0.001) and the regression relationship was ABAC = 0.00045 + 1.0069 x (BrAC x 2251) indicating excellent agreement and no fixed or proportional bias. In the absorption phase, ABAC exceeded BrAC x 2251 by at most 0.04+/-0.03 g/L when tests were made at 10 min post-dosing (p<0.05). The VBAC/BrAC ratio never stabilized and varied continuously between 1834 and 3259. There was a proportional bias between VBAC and BrAC x 2251 (ABAC) in the post-absorptive phase (p<0.001). The pharmacokinetic analysis of the elimination rates of alcohol and times to zero BAC confirmed that BrAC x 2251 and ABAC agreed very well with each other, but not with VBAC (p<0.001). We conclude that this new breath analyzer using free exhalation has a high precision for in vivo testing. The BrAC reflects very accurately ABAC in the post-absorption phase and substantially well in the absorption phase and thereby reflects the concentration of alcohol reaching the brain. Our findings highlight the magnitude of arterio-venous differences in alcohol concentration and support the use of breath alcohol analyzers as a stand-alone test for medical and legal purposes.     

Youthful animal abuse and later problem behavior outcomes: findings from two generations

The objective of this study was to document the long-term relationship between youthful animal abuse and a variety of problem behavior outcomes later in life. Data were used from a national, longitudinal, and multigenerational sample collected by the National Youth Survey Family Study, which assessed families across 27 years from 1977 to 2004. The analytic sample consisted of 2538 individuals who were analyzed using multivariate ordinary least squares and logistic regression modeling that controlled for important demographic factors. Hypotheses were tested across two generations separately showing that a history of animal abuse does, indeed, predict later problem behaviors, including serious offending, marijuana use, other drug use, alcohol use, and deviant beliefs. Depending on the outcome examined, each model accounts for 5–34% of the variation in respondents’ problem behaviors. Within each model, animal abuse was often one of the strongest predictors. Implications of these findings, the study’s limitations, and future research directions are discussed.     

Whistleblowing at work: The results of a survey of procedures in further and higher education

This article briefly explains the concept of whistleblowing and why it should be encouraged. It then describes the way in which the law both constrained and encouraged the disclosure of information prior to the introduction of the Public Interest Disclosure Act 1998. Having outlined the effect of the PIDA 1998, the authors present the background to their survey and summarise their results.     

More than a token gesture: NGOs and trade unions campaigning for a common cause

With the passage of the 1999 Asylum and Immigration Act in the UK, a system of vouchers for all new asylum seekers was to be introduced from April 2000. These vouchers were widely regarded as iniquitous in that they discriminated against an already vulnerable sector of society. A unique coalition between two NGOs (Oxfam GB and the Refugee Council) and a trade union (the Transport and General Workers' Union—TGWU) led to a concerted campaign against the voucher scheme that included a range of media work, political lobbying, and public awareness raising. The voucher scheme was eventually scrapped. This article draws various practical lessons on how to develop successful collaborative relationships across different social sectors. The author concludes that the principal lesson is not that NGOs must work with trade unions, but that by working with others, united by a common goal, they can challenge injustice effectively and make a difference to people's lives.