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In clinical and forensic toxicology laboratories, one commonly used method for urine specimen validity testing is creatinine concentration. In this study, workplace guidelines are examined to determine their relevance to forensic and clinical toxicology samples. Specifically, it investigates the occurrence of urine creatinine concentrations under 20 mg/dL and notes potential issues with factors influencing creatinine concentration by utilizing a simple, novel method consisting of cation‐paring high‐pressure liquid chromatography in tandem with ultraviolet detection to determine the creatinine concentration in 3019 donors. Of the 4227 sample population in this study, 209 (4.94%) were below the cutoff value of 20 mg/dL for dilute urine. Because there are many factors that can influence the urinary creatinine concentration, samples that have creatinine under the 20 mg/dL cutoff do not always implicate sample adulteration. 相似文献
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Renato Evando M. Filho M.S José Júlio C. Sidrim Ph.D. Rossana de A. Cordeiro Ph.D. Erica P. Caetano B.Sc. Marcos Fabio G. Rocha Ph.D. Raimunda Sâmia N. Brilhante Ph.D. 《Journal of forensic sciences》2010,55(5):1359-1361
Abstract: Despite the substantial literature on mycology, there are still limited reports of the interaction between fungi and human hosts in the postmortem period. Thus, the main goal of this study was to investigate the in vitro perforation test using Trichophyton mentagrophytes on hair from adult corpses in the postmortem period (gaseous period). The protocol was carried out with positive (prepubescent children’s hair) and negative controls (healthy adult hair) as well. One strain of Trichophyton rubrum was also used as a negative perforation control. Perforations were found in all the hair samples from corpses and prepubescent children after 12–14 days exposure to T. mentagrophytes and were absent in the hair samples of healthy adults. Furthermore, hair perforation was not observed with T. rubrum. Our preliminary findings suggest the use of T. mentagrophytes as a potential marker of the death interval in forensic science. 相似文献
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Bowen E Gilchrist E 《International journal of offender therapy and comparative criminology》2004,48(2):215-234
This article argues that the focus on behavioural outcomes in evaluations of domestic violence offender programmes has been too narrow, and that a more holistic approach incorporating investigation of the psychological characteristics of offenders and treatment characteristics may be required to determine what works, for whom, and under what circumstances. To this end, one interpretation of a comprehensive evaluation framework is outlined. The article hypothesises the insights to be gained by assessing the contribution of several potential mediating variables of the treatment process in the evaluation of these programmes. These variables are the heterogeneity of treatment targets in the target population; motivation to change; programme integrity variables; and therapeutic factors. The article concludes that only by implementing theoretically informed, multifaceted evaluations will we move closer to understanding the process of successful rehabilitation. 相似文献
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Haimes E 《Journal of law and medicine》2002,9(4):438-448
This article explores the social processes through which ideas about the family become translated into regulation and practice in assisted conception. Drawing on social problems literature, it is suggested that claims are made (by regulators, practitioners and others) about the desirability of certain family types and that forms of regulation occur when families transgress, in particularly obvious ways, the boundaries of those definitions. The apparently disparate examples of lesbian access to donor insemination and donor anonymity are brought together to illustrate the argument. It is also suggested that much formal regulation and clinical practice is directed towards making such transgressions less transparent, thus protecting the practice of assisted conception from unwelcome scrutiny. 相似文献
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Laub and Sampson (2003) and Paternoster and Bushway (2009) offered opposing explanations of desistance from crime. Yet, extant research has failed to test the key theoretical differences that distinguish these perspectives: 1) the temporal ordering of internal changes in identity/values and life transitions and 2) the impact of values/life transitions on offending conditional on key predictors from the opposing theory (e.g., whether marriage contributes to desistance among individuals who already hold prosocial values). We assess competing claims using data from the Pathways to Desistance. We find that within-person changes in prosocial value orientations are significantly related to within-person changes in one's likelihood of entering into serious romantic relationships and becoming employed. Conversely, life transitions are unrelated to changes in one's values. The results derived from fixed-effects Poisson models indicate high or increasing prosocial value orientations help explain offending patterns among those who enter into serious romantic relationships/get employed and help explain changes in offending among those who do not experience structural “turning points.” Marriage/cohabitation is unrelated to within-person changes in offending, whereas the impact of employment has an inconsistent relationship. Theoretical and policy implications are discussed. 相似文献
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Ashley Brooks B.S. Erica K. Creighton B.S. Barbara Gandolfi Ph.D. Razib Khan B.S. Robert A. Grahn Ph.D. Leslie A. Lyons Ph.D. 《Journal of forensic sciences》2016,61(3):594-606
Phenotypic and genotypic characteristics of the cat can be obtained from single nucleotide polymorphisms (SNPs) analyses of fur. This study developed miniplexes using SNPs with high discriminating power for random‐bred domestic cats, focusing on individual and phenotypic identification. Seventy‐eight SNPs were investigated using a multiplex PCR followed by a fluorescently labeled single base extension (SBE) technique (SNaPshot®). The SNP miniplexes were evaluated for reliability, reproducibility, sensitivity, species specificity, detection limitations, and assignment accuracy. Six SNPplexes were developed containing 39 intergenic SNPs and 26 phenotypic SNPs, including a sex identification marker, ZFXY. The combined random match probability (cRMP) was 6.58 × 10?19 across all Western cat populations and the likelihood ratio was 1.52 × 1018. These SNPplexes can distinguish individual cats and their phenotypic traits, which could provide insight into crime reconstructions. A SNP database of 237 cats from 13 worldwide populations is now available for forensic applications. 相似文献
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How do expressions of support or opposition by the U.S. federal government, influence violent hate crimes against specific racial and ethnic minorities? In this article, we test two hypotheses derived from Blalock's (1967) conceptualization of intergroup power contests. The political threat hypothesis predicts that positive government attention toward specific groups would lead to more hateful violence directed against them. The emboldenment hypothesis predicts that negative government attention toward specific groups would also lead to more hateful violence directed against them. Using combined data on U.S. government actions and federal hate crime statistics from 1992 through 2012, vector autoregression models provide support for both hypotheses, depending on the protected group involved. We conclude that during this period, African Americans were more vulnerable to hate crimes motivated by political threat, and Latinx persons were more vulnerable to hate crimes motivated by emboldenment. 相似文献
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