Analysis of 2-hydroxyimipramine in an imipramine-related fatality

A fatality following ingestion of the tricyclic antidepressant imipramine (Novopramine), acetaminophen, and ethyl alcohol is described. Imipramine, desipramine, acetaminophen, and 2-hydroxyimipramine were quantitated by high performance liquid chromatography, and ethyl alcohol by gas liquid chromatography. Concentrations of imipramine, desipramine, 2-hydroxyimipramine, and acetaminophen were: in blood--9.0, 1.1, 3.9, and 11 mg/L; in urine--92, 14, and 42 mg/L (acetaminophen not quantitated in urine). Ethyl alcohol concentration in blood was less than 10 mg/dL and 105 mg/dL in the urine by headspace gas chromatography. These findings are compared to previous reports of imipramine-related fatalities. To our knowledge, this is the first fatality reported involving imipramine where analysis included quantitation of 2-hydroxyimipramine in blood and urine.     

Policy Considerations for States Supporting Stem Cell Research: Evidence from a Survey of Stem Cell Scientists

Five states now provide funding for stem cell research, and many states are developing or debating stem cell research policies. Despite this interest, little data exist to help policy makers design policies or forecast the impact of new legislation. This article reports novel data from two surveys: one directed at those most affected by these policies—stem cell scientists—and one at a group of biomedical researchers working in less contentious fields. These data identified relatively high mobility among stem cell scientists, particularly in states with restrictive policies, and a strong preference for states with permissive policies. These findings suggest that state-specific policies may prove to be effective recruiting tools. They also suggest specific recruitment strategies and highlight the importance of first-mover advantage as states compete for the same limited pool of mobile scientists. This research aims to provide a factual basis to support ongoing policy formulation in the area.     

论冲突法上的适应问题

冲突法上的适应问题是一种法律关系的准据法同他种法律关系的准据法分别属于不同法律秩序时,应如何调整两者在适用上可能产生相互矛盾及不调和的问题。增强准据法的适应性或者说对准据法加以调整是当代冲突法的一个新动向。可以说,适应或调整程序浓缩了确定准据法的技术,冲突法上的某些制度本身就是适应观念的体现。在适应问题的解决方面,目前还难以制定统一的一般准则,总的来说,有冲突法的适应方法、实体法的适应方法和比较法的适应方法。适应问题不仅存在于法律适用阶段,而且也发生在管辖权协调和外国判决执行方面。     

Agenda Power in the Italian Chamber of Deputies, 1988–2000

We present strong evidence that governing coalitions in Italy exercise significant negative agenda powers. First, governing parties have a roll rate that is nearly 0, and their roll rate is lower than opposition parties' roll rates, which average about 20% on all final‐passage votes. Second, after one controls for distance from the floor median, opposition parties have higher roll rates than government parties. These results strongly suggest that governing parties in Italy are able to control the legislative agenda to their benefit. We also document significantly higher opposition roll rates on decree‐conversion bills and budget bills than on ordinary bills—results consistent with our theoretical analysis of the differing procedures used in each case.     

The Consequences of Electoral Institutions for Careerism

Although electoral institutions have been shown to have a variety of effects, scholars have not investigated if certain voting rules enable politicians to enjoy longer legislative careers. I took advantage of a natural experiment—a sudden transition from a semiproportional voting rule to single‐member districts with plurality voting (SMDP)—to measure the effect of electoral institutions on careerism. My analysis revealed that voting rules have a profound influence on the dynamics of legislative careers: politicians elected under SMDP are far less likely to suffer electoral defeat or to retire than those elected via cumulative voting. The findings of this study not only provide additional insight into the seat safety of politicians elected in first‐past‐the‐post systems, but moreover offer new criteria by which to evaluate the choice of electoral institutions.     

State Government,Political Competition and Education Reform: Comparative Lessons from Brazil

The article explores the connection between democratisation, decentralisation and sub‐national policy making. It seeks to explain variation in the policy choices that were made by Brazilian state governments in the definition of school governance structures following the return to democracy. Whereas some state governments decided to institute the election of school principals by parents, students and teachers, others decided on the maintenance of opaque and discretionary practices that secured the distribution of school posts according to political criteria. The research relies on primary comparative evidence from three states: Bahia, Ceará and Minas Gerais. The argument is that the institutional choices made by state governments depended on the structure of political competition and on the extent and intensity of elite divisions at the state level.