Determination of the effects of alcohol dehydrogenase (ADH) 1B and ADH1C polymorphisms on alcohol dependence in Turkey

Alcoholism is a complex genetically influenced disorder which refers to alcohol abuse and alcohol dependence. There are controversial results on the role of gene polymorphisms in alcohol dependence in the literature. Differences in population groups and selective inclusion criteria for alcohol dependence may affect results. In this study, we investigated the role of ADH1B Arg48His (rs1229984) and, ADH1C Ile350Val (rs698) gene polymorphisms in Turkish population. 100 healthy volunteers and 75 patients who were admitted to Ege University Alcohol Dependence Unit enrolled in the study. We found significant increase both in ADH1B (Arg48His) polymorphism Arg allele and Arg/Arg genotype frequency in patients. No profound connection between alcohol dependence and ADH1C Ile350Val gene polymorphism was detected. Alcohol dependence is an important health problem that depends on many genetic and environmental factors but we think that it is possible to interpret genetic risk for developing early diagnostic methods and treatment strategies by comprehensive linkage and association studies.     

Undiagnosed, untreated acute promyelocytic leukemia presenting as a suspicious sudden death

Acute promyelocytic leukemia (APL) is a subtype of acute myelogenous leukemia frequently associated with clotting abnormalities and severe hemorrhagic diathesis. The disease is associated with a high incidence of early fatal hemorrhage. We report the sudden death of a 40-year-old male without significant medical history in which foul play had been initially suspected. A thorough postmortem investigation performed on the decedent lead to the diagnosis of APL. Cause of death was a cerebellar hematoma. Underlying APL should be considered in the differential diagnosis when unexplained bleeding is encountered in a decedent. This case emphasizes the value of routinely collecting bone marrow during an autopsy to enable accurate testing and diagnosis.     

Associative Learning of Nasonia vitripennis Walker (Hymenoptera:Pteromalidae) to Methyldisulfanylmethane

Traditional methods of volatile detection used by police typically consist of reliance on canine olfaction. However, dogs have some limitations such as cost of training and time of conditioning. The possibility of using parasitic wasps for detecting explosives and narcotics has been developed. Moreover, wasps are cheap to produce and can be conditioned with impressive speed for a specific chemical detection task. We examined the ability of Nasonia vitripennis Walker to learn and respond to methyldisulfanylmethane (DMDS), a volatile discriminator of cadaver. The training aimed to form an association between an unconditioned stimulus (pupae) and the conditioned stimulus (odor source). After the training, the time spent by conditioned wasps in the DMDS chamber was measured. Statistical analysis showed that the increasing concentrations involved an increase in the time spent in the chamber containing DMDS. This study indicates that N. vitripennis can respond to DMDS, which provide further support for its development as a biological sensor.     

Migration,memory and mythification: relocation of Suleymani tribes on the northern Ottoman–Iranian frontier

This article indicates that Suleymani tribes, which were relocated from Diyarbekir region en masse to the newly conquered territories of northern Ottoman-Iranian frontiers after the mid-sixteenth-century, created a shift in the administrative and ethnic structure of the region. Although the roles of tribes were mostly seen as subordinate to the power of the Kurdish emirs, this study shows that the chiefs of Suleymani tribes, more specifically Besyan and Heyderan, became the rulers of the newly captured Safavid territories and they did not recognize the authority of their own Suleymani emirs. The writer focuses on this migration and discusses that the relocated Suleymani tribes preserved the collective memory of their migration during the nineteenth-century and their perception shaped the creation of a tribal myth, Mil-and-Zil, after the Ottoman central government disinherited the Kurdish emirs during the mid-nineteenth-century. Suleymani tribes' migration, collective memory and mythification of their own identities show that tribes were not passive subjects but they were in fact at the center of the developments of the Ottoman eastern frontier.     

Paid military service at the intersection of militarism,nationalism, capitalism,and (hetero)patriarchy: escaping without leaving ‘manhood’

The variety of the political standpoints of governments that have initiated exempted military service for several times in Turkey is a sign of a general agreement on its legitimacy. However, Turkey is a country where conscientious objection is almost a taboo. I try to decipher the assumptions behind what is (il)legitimate, and their manifestations in the sociopolitical life from a gender perspective informed by the feminist theory. I argue that what lies behind these is the interconnection between militarism, nationalism, patriarchy, and capitalism. I show how they reciprocally support each other through a critical discourse analysis of the debate on legitimacy of paid military service and illegitimacy of conscientious objection. I conclude that the nature of these debates leads to a reproduction of the hegemonic definitions of manhood and womanhood, together with the reproduction of the masculinization of the political sphere at the expense of the exclusion of and discrimination against other identities.     

On the front and at home: women in the modern Ottoman epic

Changes in gender roles are related to larger developments in the spheres of social modernization and discipline. As Ottoman society evolved into a nation through the nineteenth century, women's roles in contemporary epic literature were reassigned to domestic life, showing them protecting the hinterland and nurturing younger generations in order to satisfy the state's growing need for manpower. Gradually, Ottoman women lost whatever autonomy they may have had over their bodies, and their status vis-à-vis the state was redefined. This article examines the female characters in modern Ottoman epic literature so as to explore the reflections in this literature of the social and political transformations that occurred during the last quarter of the nineteenth century. It aims to reveal the ways in which heroic female figures created before or at the beginning of the autocratic reign of Abdülhamid II (r. 1876–1909) changed into domestic characters as the social skeleton of the regime became apparent.     

Why Tolerate Conscience?

In Why Tolerate Religion?, Brian Leiter argues against the special legal status of religion, claiming that religion should not be the only ground for exemptions to the law and that this form of protection should be, in principle, available for the claims of secular conscience as well. However, in the last chapter of his book, he objects to a universal regime of exemptions for both religious and secular claims of conscience, highlighting the practical and moral flaws associated with it. We believe that Leiter identifies a genuine and important contemporary legal and philosophical problem. We find much to admire in his reasoning. However, we raise questions about two claims that are crucial for his argument. The first claim is that it is not religion as such, but conscience that deserves toleration and respect. The second claim is that respect for religion and conscience demands ‘principled toleration’ but does not entail stronger policies of legal exemptions. Against the first claim, we argue that Leiter does not successfully distinguish religious belief from secular conscience and morality; and he does not explain why secular conscience (which shares many of religious conscience’s epistemic features) deserves respect. Against the second claim, we argue that the most promising theories of legal exemptions are not classical theories of liberal toleration.