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Innovation research has been characterized by findings which are either considered unstable or inconsistent. This article addresses some of the methodological issues that arise when one attempts to test interactive models of innovation, describes how one particular algorithm — AID-3 — can be used to refine the use of general linear models, and proposes a research strategy based on a building mode of innovation theory. As such it functions as a “how to” for those interested in designing innovation studies and also as a theoretical piece aimed at re-organizing the goals and outputs of innovation research. 相似文献
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Nelson MS Levedakou EN Matthews JR Early BE Freeman DA Kuhn CA Sprecher CJ Amin AS McElfresh KC Schumm JW 《Journal of forensic sciences》2002,47(2):345-349
Quality assurance samples submitted from the NCSBI as part of a contract with TBTG to outsource DNA Database samples showed unexpected discrepancies for the locus D16S539 when all other loci yielded identical results. Discrepancies observed included allele drop out and an imbalance in sister alleles with samples returned from TBTG. This led to a comprehensive review of the technical procedures used between the two laboratories to determine the cause of the discrepancies noted for the locus D16S539, since both laboratories were using the PowerPlex 1.1 typing kit from the Promega Corporation. The NCSBI and the TBTG utilize different extraction methods (organic extraction vs. FTA) and amplification conditions (AmpliTaq vs AmpliTaq Gold), respectively, so the exact cause of discrepancy observed was not immediately apparent. Experiments at the NCSBI associated the observed allele drop out and the imbalance of the sister alleles with the use of AmpliTaq Gold and a hot start procedure. Sequencing data revealed that a point mutation resides on the D16S539 primer-binding site that reaches polymorphic levels in African-American populations. This led to the development of a degenerate primer by the Promega Corporation to detect "missing" alleles when AmpliTaq Gold is used. The degenerate primer was then thoroughly tested to show its efficacy in detecting the "true" D16S539 profile when used. 相似文献
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Primary Attachment to Parents and Peers during Adolescence: Differences by Attachment Style 总被引:5,自引:0,他引:5
This study examines the nature of adolescent attachment to parents and peers during adolescence. A projective measure was used to classify 99 11th and 12th grade students into secure, insecure dismissing, and insecure preoccupied attachment groups. Respondents identified their primary attachment figure by nomination and by rating the level of attachment support they received from mothers, fathers, best friends, and boy/girlfriends. On average, parents and peers were equally likely to be identified as primary attachment figures but individual preference was strongly tied to attachment style. Secure adolescents significantly favored mothers over best friends, boy/girlfriends, and fathers. Although secure adolescents with romantic partners rated mothers lower on attachment support, none of the adolescents from this group nominated a boy/girlfriend as their primary attachment figure. In contrast insecure adolescents indicated a strong preference for boy/girlfriends and best friends as their primary target for attachment and nearly a third of dismissing adolescents identified themselves as their primary attachment figure. Findings are discussed in terms of individual differences in attachment during adolescence. 相似文献
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Brandt SD Martins CP Freeman S Dempster N Riby PG Gartz J Alder JF 《Forensic science international》2008,178(2-3):162-170
The psychoactive properties of N,N-dimethyltryptamine (DMT) 1a are known to induce altered states of consciousness in humans. This particular attribute attracts great interest from a variety of scientific and also clandestine communities. Our recent research has confirmed that DMT reacts with dichloromethane (DCM), either as a result of work-up or storage to give a quaternary N-chloromethyl ammonium salt 2a. Furthermore, this was observed to undergo rearrangement during analysis using gas chromatography-mass spectrometry (GC-MS) with products including 3-(2-chloroethyl)indole 3 and 2-methyltetrahydro-beta-carboline 4 (2-Me-THBC). This study further investigates this so far unexplored area of solvent interactions by the exposure of DMT to other halogenated solvents including dibromomethane and 1,2-dichloroethane (DCE). The N-bromomethyl- and N-chloroethyl quaternary ammonium derivatives were subsequently characterised by ion trap GC-MS in electron and chemical ionisation tandem MS mode and by NMR spectroscopy. The DCE-derived derivative formed at least six rearrangement products in the total ion chromatogram. Identification of mass spectrometry generated by-products was verified by conventional or microwave-accelerated synthesis. The use of deuterated DCM and deuterated DMT 1b provided insights into the mechanism of the rearrangements. The presence of potentially characteristic marker molecules may allow the identification of solvents used during the manufacture of controlled substances, which is often neglected since these are considered inert. 相似文献
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Few studies have empirically validated the assertion that female and male sex offenders are vastly different. Therefore, utilizing a matched sample of 780 female and male sex offenders in New York State, the current study explored differences and similarities of recidivism patterns and risk factors for the two offender groups. Results suggested that male sex offenders were significantly more likely than female sex offenders to be rearrested for both sexual and nonsexual offenses. However, limited differences in terms of risk factors between female and male sex offenders were found. 相似文献
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R I Vila J V Martin C V Wetli R Freeman 《The American journal of forensic medicine and pathology》1990,11(3):241-243
Authentic black-powder muzzle-loader weapons and replicas are used today primarily for hunting game such as deer and hogs. The following is a case presentation of accidental death from cerebral trauma caused by a .45-caliber black-powder-rifle breech plug implanting in the victim's brain. 相似文献