Molecular genetics of sudden cardiac death

Sudden cardiac death (SCD) is one of the most common causes of death. An important number of sudden deaths, especially in the young, are due to genetic heart disorders, both with structural and arrhythmogenic abnormalities. In recent years, significant advances have been made in understanding the genetic basis of SCD. Identification of the genetic causes of sudden death is important because close relatives are also at potential risk of having a fatal cardiac condition. A comprehensive post-mortem investigation is vital to determine the cause and manner of death and provides the opportunity to assess the potential risk to the family after appropriate genetic counselling. In this paper, we present an update of the different genetic causes of sudden death, emphasizing their importance for the forensic pathologist due to his relevant role in the diagnosis and prevention of SCD.     

Juvenile Justice Processing:The entangled effects of race and urban poverty

This study addresses the issue of how race and urban poverty affect minority overrepresentation in the juvenile justice system, using data from 2,003 court cases referred to 13 urban Ohio juvenile courts in 1989. Results of logistic regression analyses show that: 1) minority offenders are more likely to be detained than whites; 2) detention status augments juveniles' chances of being adjudicated and confined; 3) minority juveniles who are from welfare families are more likely to be confined than their self-sustaining counterparts. A cultural stereotype based on juveniles' race and class constitutes the basis of differential treatment.     

Democracy by Competition: Referenda and Federalism in Switzerland

Competition is not only a prerequisite for the successful workingof economics but also of political coordination systems. Weargue that popular referenda and federalism are the key factorsin maintaining competition in the political arena. Competitiveeconomic or political markets require free entry and exit andthe absence of regulations that prevent suppliers from beingsuccessful with the best product-be it goods or services inthe form of policies-and prevent citizens from choosing freely.     

Lasting Memory Centennial of Dr. Kotnis—Father’s Comrade-in-Arms

The 100th anniversary of the birth of Dr. Dwarkanath Shantaram Kotnis is approaching. I have read many relevant articles about him on the Internet bringing back memories of past events and my father.     

Outcome,Process and Power in Direct Democracy – New Econometric Results

Based on survey data for Switzerland, new empiricalfindings on direct democracy are presented. In thefirst part, the authors show that, on average, public employeesreceive lower financial compensation under more directdemocratic institutions. However, top bureaucrats aremore constrained in direct democracies and have to becompensated by higher wages for that loss of power.In the second part, they demonstrate that reportedsubjective well-being of the population is much higherin jurisdictions with stronger direct democraticrights. This is not only the case because people valuepolitical outcomes higher but also because they derive utilityfrom the political process itself.     

Cone‐beam Computed Tomography for Analyzing Variations in Inferior Alveolar Canal Location in Adults in Relation to Age and Sex*

Abstract: Previous studies have indicated that the relative position of the inferior alveolar canal and its mental and mandibular foramina in adults vary with age and show sexual dimorphism. Conceivably, these purported differences could be of forensic value for determining identity of human remains. This study was designed to determine the influence of age and sex on the relative position of inferior alveolar canal and its foramina in cone‐beam computed tomography (CBCT) studies of adults. Existing CBCT studies of the maxillofacial region from dentate adult patients selected at random and ranging in age from 18 to 80 years (110 women and 55 men) were acquired, and the location of the inferior alveolar canal was assessed at three points: the mandibular foramen in axial view, the inferior alveolar canal in coronal view, and the mental foramen in coronal view. Measurements were also expressed for the mental foramen as the percentile position from the nearest superior bony crest to the inferior border; corresponding position of the mandibular foramen from the anterior to the posterior border of the mandibular ramus; and for the inferior alveolar canal at the level of first permanent molar from the nearest buccal bony surface to the lingual surface and from the superior alveolar crest to the inferior border. Regression analyses were performed on the variables with regard to the effects of age and sex. Most analyses resulted in no statistical significance (p < 0.05). A few of the sex‐specific traits demonstrated near‐statistically significant effects; however, these characterizations generally resulted in a 1% or less change per age decade. Overall, the results demonstrated that the relative location of the inferior alveolar canal and associated foramina in adults remain fairly constant without regard to age and sex.     

Sarcomeric gene mutations in sudden infant death syndrome (SIDS)

In developed countries, sudden infant death syndrome (SIDS) represents the most prevalent cause of death in children between 1 month and 1 year of age. SIDS is a diagnosis of exclusion, a negative autopsy which requires the absence of structural organ disease. Although investigators have confirmed that a significant percentage of SIDS cases are actually channelopathies, no data have been made available as to whether other sudden cardiac death-associated diseases, such as hypertrophic cardiomyopathy (HCM), could be responsible for some cases of SIDS. The presence of a genetic mutation in the sarcomeric protein usually affects the force of contraction of the myocyte, whose weakness is compensated with progressive hypertrophy and disarray. However, it is unclear whether in the most incipient forms, that is, first years of life, the lack of these phenotypes still confers a risk of arrhythmogenesis. The main goal of the present study is to wonder whether genetic defects in the sarcomeric proteins, previously associated with HCM, could be responsible for SIDS. We have analysed 286 SIDS cases for the most common genes implicated in HCM in adults. A total of 680 mutations localised in 16 genes were analysed by semi-automated matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDITOF-MS) using the Sequenom MassARRAY(?) System. Ten subjects with completely normal hearts showed mutated alleles at nine of the genetic variants analysed, and one additional novel mutation was detected by conventional sequencing. Therefore, a genetic mutation associated with HCM may cause sudden cardiac death in the absence of an identifiable phenotype.     

Bankruptcy in divorce: The litigation tactic of the angry spouse

A matrimonial proceeding on its own is complex and can have far-reaching implications. Add in a spouse filing for bankruptcy in the midst of the proceeding, and the process becomes even further complicated and quite possibly hostile. This Note analyzes the bad-faith tactics of debtor spouses filing for bankruptcy in the middle of a divorce proceeding and proposes an amendment to the Bankruptcy Code that permits bankruptcy courts to dismiss bad faith petitions before they negatively impact divorce proceedings.