University-industry consortium agreements Center for Process Analytical Chemistry: A case study

There is a surfeit of articles, books, and conferences on the subject of university-industry collaboration, but few of them address specific, pragmatic issues related to the development of an operable sponsorship agreement. This article focuses on the terms of the agreement negotiated with industry sponsors of the National Science Foundation (NSF) Industry-University Collaborative Research Center (IUCRC), established at the University of Washington in 1984 as the Center for Process Analytical Chemistry (CPAC). Over the past 11 years, CPAC has grown dramatically and achieved important successes, but some of the terms in the initial agreement have proven to be problematic, particularly those dealing with intellectual property rights. This article reviews the nature of the problems and explains the solutions negotiated by participants as part of a revised agreement implemented in 1992.     

Expression of adhesion molecules in skin wounds: diagnostic value in legal medicine

The adhesion molecules identified in recent years can help improve the diagnosis of the wound age, especially of injuries with a short survival time. This is also indicative of the vitality of the wounds. The material investigated in the study originated from 465 skin wounds. The samples were taken from human autopsy material, during the surgical treatment of wounds (excision) of patients and from experimental incised wounds of mice. To judge the age of skin wounds the endothelial adhesion molecules were detected in paraffin sections after autoclaving and using the ABC technique. Human skin wounds: strong positive staining was observed of ICAM-1 1.5 h at the earliest and 3.5 days at the latest, for the P-selectin 3 min at the earliest and 7 h at the latest, for the E-selectin 1 h at the earliest and 17 days at the latest and for VCAM-1 3 h at the earliest and 3.5 days at the latest after the time of injury. The L-selectin was expressed constitutively. Mice skin wounds: strong positive immunohistochemical reactions were found as a rule earlier than in human skin wounds. The detection of an increased expression of ICAM-1, VCAM-1 and P- and E-selectins can improve the wound age assessment in injuries with short survival times.     

Electoral Competitiveness and the Voting Decision Evidence from the Pooled Senate Election Study

Scholarship on congressional elections holds that competitive elections are different from noncompetitive elections. Specifically, some scholars argue that the level of competitiveness determines the criteria or the weight of various criteria for the voting decision. Using the 1988–1990–1992 Pooled Senate Election Study, this research finds that enhanced electoral competitiveness increases the importance of assessments of presidential performance on the voting decision. These effects are particularly large for voters with high levels of educational attainment. Contrary to previous research, in highly competitive elections the role of ideological considerations is smaller than in less competitive elections.     

Death and Turnout: The Human Costs of War and Voter Participation in Democracies

War heightens public interest in politics, especially when human lives are lost. We examine whether, and how, combat casualties affect the decision to vote in established democracies. Drawing from social psychology research on mortality salience, we expect increasing casualties to increase the salience of death, information that moves people to defend their worldview, especially nationalistic and ideological values. By heightening the importance of values, we propose that combat casualties increase the benefits of voting. In particular, we expect the effect of combat casualties to be pronounced among the least politically engaged. Using both cross‐national data of elections in 23 democracies over a 50‐year period and survey data from the United States and United Kingdom during the Iraq and Afghanistan wars, we found that mounting casualties increase turnout. Furthermore, as expected, we found the effect of casualties to be most pronounced among those least interested in politics.     

Limits to learning: the struggle to adapt to unintended effects of international payment for environmental services programmes

International Environmental Agreements: Politics, Law and Economics - This article pioneers new thinking on learning by organizations created by international environmental agreements, especially...     

Economic globalization and regional penetration: The failure of networks in Baden-Württemberg

Abstract. This paper explores the emergence of direct linkages between the international economy and the state government of Baden–Württemberg, Germany. In the early 1990s Baden–Württemberg embarked on a plan in which the laender government took the lead in organizing a large–scale, high technology project for the development of interactive television. Creating a 'network' between itself and major economic actors the laender government sought to enhance the economic development of the region. However, as the economic actors involved in the project questioned the economic viability of interactive television, they began to withdraw from the project. The project's failure demonstrates the incompatibility of political objectives with the economic goals of actors in a globalized economy. We conclude that as attractive as the network approach may be for regional and national governments, it is likely to be successful only where both sets of actors see the outcome as enhancing their respective priorities (political legitimacy and economic gains).     

The ‘heart’ of Eurasia? Kazakhstan's centrally located capital city

In a world still dominated by a geopolitical system of territorial states, one tool in the state- and nation-building repertoire is the strategy of moving a capital from one city to another, and to an ostensibly more ‘central’ location of a geometrically conceived territory. From Ankara to Brasília, the technique has been used in a variety of places around the world, and Kazakhstan's new capital since 1997, Astana, is one more recent iteration. Taking a Foucauldian approach to analysing political technologies of government, the author examines the strategy of the centrally located city and considers how it has been instrumental to simultaneously producing a ‘state effect’ and a ‘territory effect’ in newly independent Kazakhstan. Part of a larger mixed-methods study, this article draws on a diverse range of methods, including data from interviews, participant observation, textual analysis, focus groups and a country-wide survey.     

Microscopical discrimination of human head hairs sharing a mitochondrial haplogroup

In forensic analyses, determining the level of consensus among examiners for hair comparison conclusions and ancestry identifications is important for assessing the scientific validity of microscopical hair examinations. Here, we present data from an interlaboratory study on the accuracy of microscopical hair comparisons among a subset of experienced hair examiners currently analyzing hair in forensic laboratories across the United States. We examined how well microscopical analysis of hair can reliably be used to differentiate hair samples, many of which were macroscopically similar. Using cut hair samples, many sharing similar macroscopic and microscopic features, collected from individuals who share the same mitochondrial haplogroup as an indication of genetic relatedness, we tested multiple aspects that could impact hair comparisons. This research tested the extent to which morphological features related to ancestry and hair length influence conclusions. Microscopical hair examinations yielded accurate assessments of inclusion/exclusion relative to the reference samples among 85% of the pairwise comparisons. We found shorter hairs had reduced levels of accuracy and hairs from populations examiners were not familiar with may have impacted their ability to resolve features. The reliability of ancestry determinations is not yet clear, but we found indications that the existing categories are only somewhat related to current ethnic and genetic variation. Our results provide support for the continued utility of microscopical comparison of hairs within forensic laboratories and to advocate for a combined analytical approach using both microscopical analysis and mtDNA data on all forensic analyses of hair.     

Heart rate changes in response to mild mechanical irritation of the high cervical spinal cord region in infants

Alterations in the heart rate were monitored before, during and after the application of a unilateral mechanical impulse to the high cervical spinal cord region which was administered strictly in connection with the so called manual therapy (diagnosis= KISS). The investigation is based on a survey of 695 infants between the ages of 1 and 12 months. A notable change in the heart rate was evident in 47.2% of all examined infants (n= 695). In 40.1% of these infants, the change in heart rate was characterized by heart rate decrease of 15-83% compared to control conditions. Infants in their first 3 months of life responded more often with a severe bradycardia (50-83% decrease), older infants (7-12 months) more often with a mild bradycardia (15-49.9% decrease). This comparison revealed a significantly increased occurrence of severe bradycardia in the younger age group compared to the group of children >3 months (significance 0.0017). In 12.1% (n= 84) of the infants, the bradycardia was accompanied by an apnea. We discuss the hypothesis that mechanical irritation of the high-cervical region serves as a trigger that may be involved in sudden infant death (SID).