Harmonizing the international regulation of embryonic stem cell research: possibilities, promises and potential pitfalls

Despite near unanimous global opposition to human reproductive cloning, the United Nations has been unable to reach a consensus as to how cloning practices should be regulated at the international level. As a result, the U.N. objective of establishing binding international regulations governing cloning and stem cell research has yet to be achieved. Given the lack of consensus that exists within the global community on this topic, it seems that any attempt to harmonize the international regulation of cloning and stem cell science will face important obstacles. This paper seeks to illuminate the particular challenges to harmonizing international laws and policies related to stem cell research and human cloning, and to investigate potential methods for overcoming these challenges. By drawing on two other areas in which regulatory harmonization has been attempted, namely: environmental and human safety aspects of international trade, and pharmaceutical research and development, we study approaches to global regulatory harmonization. We conclude that while the challenges to harmonization are diverse and important, so too are the benefits of establishing uniformity in approaches to stem cell research worldwide. This paper proposes a model for harmonizing the regulation of stem cell research that focuses on broader norms and principles rather than specific rules. It further recommends that such harmonization should occur through a process initiated and developed by an independent international agency marked by diversity, both in terms of the cultural identities and perspectives represented, and the interdisciplinary expertise of its members.     

A simulation for exploring the effects of the "trait list" method's subjectivity on consistency and accuracy of ancestry estimations

The nonmetric "trait list" methodology is widely used for estimating ancestry of skeletal remains. However, the effects of the method's embedded subjectivity on subsequent accuracy and consistency are largely unknown. We develop a mathematical simulation to test whether variation in the application of the "trait list" method alters the ancestry estimation for a given case. Our simulation explores how variations in (i) trait selection, (ii) number of traits employed, and (iii) ancestry choice thresholds affect the ancestry estimation of an unidentified skeleton. Using two temporally and geographically diverse samples, the simulation demonstrates that trait selection, trait quantity, threshold choices, and the exclusion of high-frequency traits had minimal effect on estimation of general ancestry. For all data sets and Runs, Accuracy(AS) was maintained above 90%. The authors close with a discussion on the logistical issues present when choosing traits, and how to avoid ancestry bias.     

The Arrow--Directional Semiotics: Wayfinding in Transit

Airport language is a spectacle, an interface for social relations between humans and machines. Signage intensifies social relations--reconfiguring territories of geophysical/architectural space into territories of recognition that speak to a productive power of language that is fundamentally non-representational. Airports are walked, the signs don't accompany or reflect upon the airport, they are machined into it. The traveller navigates through a highly textually mediated space where the signs not only enact semioticised territories but also directly intervene into the material machinic processes of travelling. As Guattari (1992: 49) might say, these point-signs 'don't simply secrete significations'. They activate the bringing into being of ontological universes. This paper focuses on 'signage' in a quite expanded yet also limited sense. It focuses on the increasing standardisation of the signifying semiologies of transit wayfinding systems which signal the primacy of pragmatic interactivity in the communicative event of walking the airport. If the controlling semiosis of non-places is, as Auge´ (1995) notes, the dominant space of supermodernity, then a thorough consideration of such signifying technologies would seem in order. This paper focuses on one of the most ubiquitous signs at the airport: the arrow. The airport's arrow is an asemic figure through which perhaps to read the semiotic technologies of the airport itself. The arrow is both a tool and a trope for the imperatives of global transit: it turns place into passage, striates space into controlled flows, and urges the traveller to 'move on'. It is a point sign that leads the way to a consideration of the technologies, both semiotic and a-semiotic, that provide the navigational and behavioural guidance that is increasingly in evidence, not only at the airport but in all public spaces.     

‘Royal supremacy restored?’ Scottish parliamentary independence in the Restoration era, 1660–88

SUMMARY

The constitutional settlement instituted by the Scottish Parliament in 1661–63 has traditionally been seen as a victory for the crown and a disaster for the parliamentary estates, since all of the hard-won constitutional gains introduced during the Covenanting era were largely swept away in favour of a complete reassertion of the king's prerogative powers. Nevertheless, despite the initial flourishing of royalist enthusiasm that marked the early Restoration period, in only a matter of years Scotland's political elites were once more engaged in battle with an authoritarian monarch and his increasingly dictatorial ministers of state. By as early as the mid-1660s, armed rebellion had erupted in the localities, religious non-conformity threatened to fragment the church, and rumbles of dissent within the parliamentary chamber itself were becoming more difficult to ignore. Can it be concluded, therefore, that it would prove impossible to imagine away the momentous events of the Covenanters' radical experiment in government, and that some of those constitutional and ideological principles survived into the Restoration era, effectively sowing the seeds of what would become the Revolution of 1689–90?     

Win–Win? Early experience from local area agreements

Local Area Agreements (LAAs) are a mechanism for delivering improved outcomes for local people, through recasting governance relationships between central government and localities and between local agencies. This paper assesses the effectiveness of LAAs in reforming these critical relationships, drawing on research carried out in 2004–06 into the round one and two negotiations. These early negotiations highlighted the complexity of ‘central–local relations’; a coherent approach across Whitehall was hampered by differences in departmental culture and in the nature of relationships with local delivery agencies, while the new role for Government Offices was ambiguous. Nevertheless the early LAAs represented a major step forward in terms of local–central relations. Within localities, the process of developing LAAs proved challenging and highlighted governance weaknesses; however in the main participants report that partnerships have been greatly strengthened as a result. These early experiences provided rich learning, and policy has developed significantly since the pilots. At the time this research ended there was not yet any conclusive evidence on the balance of costs and benefits. However, over time LAAs have the potential to bring about a transformation in governance relationships and, in turn, the delivery of services to address cross-cutting outcomes.     

Cohabitants, Property and the Law: A Study of Injustice

With cohabitation outside marriage becoming increasingly common, the law's response to the problems that arise on separation has become a key issue for public and family policy. This article draws upon the findings of a qualitative empirical study of how property disputes are handled when cohabitants separate. It argues that the unfairness of the current law is best understood as stemming from a failure to recognise the situation that arises as one of unjust enrichment. It shows that the complexity and unpredictability of the law make it difficult to bargain effectively in the shadow of the law. It suggests that the need for reform goes beyond the introduction of a discretionary regime, such as that proposed by the Law Commission, to reform of conveyancing and property law and practice to facilitate initial, as well as post-separation private ordering.     

Reigniting the fire: a contemporary research agenda for social,political and nonprofit marketing

The paper reports on the core challenges faced by the nonprofit, political and social marketing disciplinary areas and suggests a series of research agendas to develop theory and practice to meet these challenges.

• Social marketing's research agenda involves the continued adaptation of the new developments in commercial marketing, whilst building a base of social marketing theory and best practice benchmarks that can be used to identify, clarify and classify the boundaries of social marketing against social change techniques.
• Nonprofit marketing is pursuing the dual research agenda of developing the theory and practice of social entrepreneurship whilst seeking deeper consumer‐based research to understand motivations for charitable behaviour and gift giving.
• Political Marketing's research agenda looks for an increase in the level of background research, core data and market research to use as a basis for developing more advanced theoretical and practical models. In addition, as political marketing is being transferred internationally between a range of political and electoral systems, there is a need for comparative research into both the relevance and effectiveness of these techniques to isolate nation independent and nation dependent political marketing strategies and campaigns.

Copyright © 2007 John Wiley & Sons, Ltd.