Fulminant liver failure in a young child following repeated acetaminophen overdosing

Acetaminophen (paracetamol), a widely used analgetic drug, is well tolerated at therapeutic doses, but may cause severe hepatotoxicity when ingested in large overdose. Self-poisoning is still very popular in adults and accidental ingestion of one single overdose occurs occasionally in children. In contrast, lethal intoxication in children after repeated administration of therapeutic doses is a very rare event. This case report describes an iatrogenic acetaminophen overdosing in a 5-year-old child receiving 8.5 g acetaminophen in 48 h. Fulminant liver failure developed within 60 h. Autopsy findings included panlobular liver cell necrosis. Acetaminophen serum levels were rather low compared to cases with ingestion of one single overdose. Postmortem diagnosis of chronic acetaminophen intoxication as cause of death should include the clinical history as well as, if available, the calculated drug serum half-life.     

The Effects of Partisan Trespassing Strategies Across Candidate Sex

Political Behavior - Candidates frequently engage in partisan trespassing strategies where a candidate will highlight issues and traits associated with stereotypes of the opposing political party....     

Carbon monoxide poisoning caused by a hot plate

The autopsy of a woman aged 85 years who was found dead sitting in her kitchen bent over the kitchen-table revealed a fatal carbon monoxide poisoning. Subsequent inquiries excluded the chimney flue and above all the gas-fired water heater from being the CO-generator. Operating experiments upon the gas stove including the ultimately used pot and the Hot Plate likewise found showed a CO-content of 100 ppm in the room-air after half an hour, there upon an over-proportional ascent of the CO-concentration. This CO-production was brought about by the considerable deformation of the Hot Plate, which has obviously been used for years. The lack of an adequate warning in the directions for use of such products is remarked critically.     

Elemental analysis of human cremains using ICP-OES to classify legitimate and contaminated cremains

The Tri-State Crematory Incident in Nobel, GA (February 2001) revealed limitations in traditional human cremated remains (cremains) analytical methodology. The goal of this study was to develop a method for effectively classifying questionable sets of cremains as legitimate or contaminated. Eighty-eight samples of known human cremains, concrete, mixtures of the two, and questionable sets of cremains were acid digested and analyzed for 21 elements by Inductively Coupled Plasma-Optical Emission Spectroscopy (ICP-OES). Variable cluster and principle component analyses identified the seven elements (Sb, B, Li, Mn, Sr, Tl, and V) used to develop discriminant functions to classify questionable sets into two groups: cremains and concrete. The discriminant analysis shows that at the 0.90 probability level, mixtures of 50% or less human content were classified as concrete. Mixtures with 90% human content classified as cremains. Sixty percent and 75% human content mixtures remained in the questionable classification, but as the concentration of human increased in the mixture, the probability of assignment to the known cremains group increased. Most of the questionable human samples classified as cremains. This is a pilot study and cannot yet satisfy Daubert standards for courtroom admissibility, but it indicates that it is possible to determine the legitimacy of cremains using elemental analysis by ICP-OES coupled with multivariate statistical analysis.     

Risks and Opportunities of Faith and Culture: The Case of Abused Jewish Women

Intimate partner abusers often focus on physical violence, but abuse may also include exploiting a partner’s faith or subculture. Alternatively, faith or subculture may be a source of strength and support for victims. We explored this by analyzing case files from a Jewish domestic violence services agency. Jewish identity conditions women’s experiences with intimate partner abuse through the use of Judaism as a “tool” for abuse, the role of Jewish holidays and observances, and the role of the Jewish community. While partners of abused Jewish women often perverted the laws and traditions of Judaism to control their partners and the reaction of the larger community varied, being part of an integrated cultural and religious community offered support for some women.     

Ideas, innovations, and networks: a new policy model based on the evolution of knowledge

In this paper, we argue that a new policy model for science and technology is needed and must be evolutionary in nature. The paper proposes utilizing the idea innovation network theory as a framework for assessing sectoral innovation patterns and identifies six types, or “arenas,” of research that are linked to innovation within these networks. Following the idea innovation network theory, the paper argues that two societal trends, the fragmentation of markets and the growth of knowledge, are driving organizations toward greater functional differentiation. Successful innovation will occur when these differentiated organizations become closely linked within innovation networks that integrate the arenas of research. The paper argues that this framework has predictive power, in that it allows the identification of path-dependent blockages or gaps within idea innovation chains that prevent the emergence of effective innovation networks in different countries. Policy makers can play an important role by fostering the development of tightly coupled networks that include organizations involved in each of the types of research. The paper provides empirical support for the framework using a cross-national European study of the telecommunications and pharmaceutical industries.