HPLC of basic drugs on microparticulate strong cation-exchange materials - a review

Propylsulphonic acid (SCX)-modified silica HPLC columns used with methanol or aqueous methanol eluents of appropriate pH and ionic strength can give good retention and peak shape for basic drugs. In the system studied, eluent pH influenced retention via protonation of basic analytes, the pK(a) of the analyte indicating the pH where retention begins to decrease at constant ionic strength. At constant pH, retention is inversely proportional to ionic strength for protonated bases and quaternary ammonium compounds. The underlying retention mechanism appears to be ion-exchange with the SCX moieties, although ionized surface silanols may also contribute to retention at higher eluent pH values. In capillary electrochromatography (CEC) unprecedented efficiencies, but similar selectivity, to that observed in conventional HPLC have been obtained for a standard range of basic drugs using Waters Spherisorb S3SCX.SCX-modified silica columns can be used in the HPLC of many basic drugs, including some compounds that are poorly retained on unmodified silica using methanol-rich eluents. N-Desalkyl and sulphoxide metabolites are often resolved at an appropriate eluent pH. Even analogues differing by a methylene unit in a side-chain remote from a basic centre are often resolved. Applications of Waters Spherisorb S5SCX columns include HPLC of antimalarials such as chloroquine and quinine, cardioactive drugs, for example amiodarone and flecainide, antipsychotics (clozapine, olanzapine), and antidepressants (amitriptyline, clomipramine, dothiepin, fluoxetine) and their N-desalkyl metabolites. Major practical features of these systems are that (i) acidic and neutral compounds are not retained, (ii) solvent extracts can be injected directly, and (iii) eluent recycling can be performed routinely.     

The Impact of Television,Electronic Games,and Social Technology Use on Sleep and Health in Adolescents with an Evening Circadian Preference

Journal of Youth and Adolescence - There are mixed findings when examining if technology use is harmful for adolescent sleep and health. This study builds on these mixed findings by examining the...     

A Dominant SNP in a Unionist Scotland? The 2019 UK General Election in Scotland

The UK general election in December 2019 produced a resounding victory for Boris Johnson’s Conservatives, returning a majority government and the mandate for Brexit that he had campaigned for. The picture was less rosy for the Conservatives in Scotland, where his party lost half its seats to the SNP. This article reviews the election outcome in Scotland, considering the fortunes of each of the main parties, and projects forward to the devolved election in 2021, when the parties will once again debate the key constitutional question in Scotland.     

Applying regression discontinuity designs to American political development

Public Choice - Students of American political development (APD) have long been interested in questions related to the development of “state capacity” in the United States. The apparent...     

Policy-making in a Restructured State: The Case of the 1991 Health Reform Policy in New Zealand

The pressure for efficiency and accountability that led to reform of public institutions worldwide has had implications for public policy-making as well as the management of public services. The difficulties of providing a coordinated and efficient policy process that can respond to the requirements of a more managerialist style of government were evident in New Zealand in the 1980s and early 1990s. The policy process in 1990–91 leading to the introduction of health reform proposals provides an illuminating case study of the tension between participation and speed, and between traditional pluralist and managerialist approaches to policy development. The implications of this for subsequent implementation are discussed.     

The Mills report,the Manley subsidy proposals,and the business of major‐league sport

Abstract: This article examines the debates over subsidies to professional sports teams that have been the focus of much attention and passion in Canada over the past several years, debates that led to the report by Dennis Mills,Sport in Canada: Everybody's Business, and to John Manley's ill‐fated proposals to offer subsidies to Canadian professional sports operators. The article reviews the arguments put forward by the sports industry: that major‐league hockey and baseball teams make substantial economic contributions, both directly and indirectly, to the cities in which they are located and that Canadian teams, especially those based in smaller cities, need substantial reductions in their public costs (taxes and/or rents) in order to “level the playing field” with their US. competitors. The authors argue that the commissioned studies on which these claims are based systematically overstate the economic impacts of professional sports and are not supported by independent research. The authors also argue that the difficulties facing Canada's “small market” teams are not primarily the result of higher taxes; rather, they follow from changes in the sports industry over the last decade (notably, much higher player salaries). This means that in order to remain competitive, teams must be able to generate far greater revenues than were needed only a decade ago. When one examines the new economy of professional hockey, in particular, with its heavy reliance on local television and advertising revenues and on the purchase of luxury seating by the local corporate sector, it is hard to avoid concluding that even with public subsidies teams based in provincial Canadian cities may no longer be able to compete in the major leagues. Finally, the authors consider the cultural argument that nhl hockey is a Canadian tradition and warrants support on “heritage,” as opposed to economic, grounds. However, the authors conclude that both professional sports and Canada have changed so much in recent decades that commercial sport is not an appropriate candidate for public subsidy. Sommaire: Dans cet article, on examine la question des subventions aux équipes de sports professionnels qui a fait l'objet d'un vif débat au Canada au cours de ces dern‐ières années. Ce débat avait entraîné le rapport de Dennis Mills,Sport in Canada: Everybody's Business, et les propositions soumises ans succès par John Manley pour offrir des subventions aux exploitants de sports professionnels au Canada. On y présente les arguments du secteur des sports: les équipes de hockey et de baseball des ligues majeures font un apport économique direct et indirect considérable aux villes oú elles se trouvent, et les équipes canadiennes, surtout celles basées dans des villes plus petites, ont besoin d'une réduction substantielle de leurs coûts publics (impôts et/ou loyers) afin d'égaliser le terrain de jeu par rapport à leurs concurrents américains. Selon les auteurs, les études commanditées qui justifient ces prétentions exagèrent systématiquement les retombées économiques des sports professionnels et elles ne sont pas appuyées par des recherche indépendeants. Par ailleurs, les difficultées auxquelles font face les équipes de petit marché au Canada ne découlent pas d'une forte impositoin mais plutôt de l'évolution survenue dans l'industrie du sport au cows de cette dernière décennie (notamment, la forte hausse du salaire des joueurs). Pour rester concurrentielles, les équipes doivent recueillir un revenue très supérieur à celui d'il y a dix ans. Lorsqu'on examine la nouvelle économie du hockey professionnel en particulier, fortement tributaire du revenue prodigué par la télévision et la publicité locales et de l'achat de siges au prix fort par les entreprises de la localité, il est difficile d'éviter la conclusion que, même avec des subventions publiques, les équipes basées dans des villes provinciales au Canada auront du mal à survivre dans les lques majeures. Enfin, les auteurs examinent l'argument culturel voulant que le hockey de la lnh soit une tradition canadienne qui mérite d'être appuyée à titre patrimonial plutôt qu'économique. Leur conclusion: les sports professionnels et le pays lui‐même ont tellement évolué ces dernières décennies que le sport commercial n'est pas un candidat valable pour des subventions publiques.     

The South AfricdCanada Program on Governance: an experiment in supporting democracy

Abstract: The South Africa/Canada Program on Governance is a am‐funded initiative that assisted South Africa's transition to democracy in 1993 and 1994 and since then has supported the country's leaders in building the basic systems of government. It has done this by making available to senior South African elected and appointed officials Canadian public‐service practitioner advice, focusing always on the key people, key places, and core processes of government. The program has provided advice on constitutional arrangements, the establishment of a representative public service, support to the centre of government, planning and budgeting, and services delivery through its special advisers resident in Johannesburg, through workshops, through study visits to Canada for South Africans, and through the assignment of Canadian public servants to carry out projects in South Africa. Much of its work has been carried out under the auspices of twinning arrangements between six Canadian provinces and six South African provinces and their respective national departments of public works. As the program draws to an end, the authors, two of the program's special advisers, argue that in addition to providing important assistance during the transition to democracy, the program has been successful in a number of identifiable ways by supporting good governance in South Africa. They also argue that there is good reason for continued Canadian assistance in this area. Sommaire: Le Programme de gouvernance sud‐africain, une initiative financée par l'ACDI, a facilité en 1993 et 1994 l'évolution démocratique de l'Afrique du Sud et a aidé les leaders de ce pays àériger les systèmes essentiels de gouvemement. Le Programme a réalisé cela en offrant aux cadres supérieurs et aux élus sud‐africains les conseils de praticiens de la Fonction publique canadienne, en se concentrant chaquefois sur les personnes‐clé, les endroits‐clé et les processus fondamentaux du gouvernement. Grâce aux efforts de conseillers spéciaux à Johannesburg, à des ateliers, aux voyages d'études du Sud‐Africains au Canada et à l'affectation de fonctionnaires canadiens à des projets en Afrique du Sud, le programme a prodigué des conseils sur les arrangements constitutionnels, la mise sur pied d'une Fonction publique représentative, le soutien aux organismes centraux du gouvernement, la planification et la budgétisation ainsi que la prestation de services. Les activités du Programme ont été réalisées grâce au jumelage de six provinces canadiennes à six provinces sud‐africaines, ainsi que des ministères des travaux publics respectifs des deux pays. Sous sa forme actuelle, le programme viendra àéchéance bientot. Selon les auteurs, deux des conseillers spéciaux du programme, ce dernier a réussi à favoriser la bonne gouvernance en Afrique du Sud en plus d'aider le passage à la démocratie. Toujours don eux, il serait judicieux de continuer à offrir de l'assistance canadienne dans ce domaine.     

Benjamin Franklin and the Traditions of American Diplomacy

Every generation forgets Benjamin Franklin's diplomatic contributions to its peril, the author writes. He outlines this American in Paris’ major diplomatic achievements and offers important lessons for today.