Isolation and characterisation of a novel sildenafil analogue adulterant,desmethylpiperazinyl propoxysildenafil,in a dietary supplement

A new sildenafil analogue was detected during routine screening of dietary supplements suspected to be adulterated with an erectile dysfunction drug(s) using HPLC-DAD. The UV spectrum of this compound was highly similar to that of sildenafil and almost identical to that of desmethylpiperazinyl sildenafil. The analogue was purified by using semi-preparative HPLC and structurally elucidated by performing mass spectrometric and NMR spectroscopic experiments. The spectral data revealed that this sildenafil analogue bears an n-propoxy group instead of an ethoxy group and possesses no methylpiperazinyl moiety. The isolated compound, structure of which was further confirmed by spectral comparison with synthetic one, was thus named as desmethylpiperazinyl propoxysildenafil.     

Fingermark visualisation on metal surfaces: An initial investigation of the influence of surface condition on process effectiveness

Fingermark recovery from metal surfaces is an area of operational interest, both from the association of metals with weapons used in violent crime and from the increasing incidence in metal theft. This paper reports a feasibility study into the effectiveness of a range of fingermark visualisation processes in developing fingermarks on clean metals (brass, bronze and stainless steel), and on the same metals after prolonged exposure to an outdoor environment. Scanning electron microscopy (SEM) was used to investigate how the surface type and condition could influence the development of fingermarks for each of the processes used. It was found that the behaviour observed varied between each of the processes (cyanoacrylate fuming, Lumicyano?, gun blueing and carbon-based powder suspension). In some cases the chemical composition of the surface affected the development of the mark more than the surface condition, and in other cases the reverse was true. The best performing processes differed according to the surface type and condition, with cyanoacrylate fuming processes working best on brass and bronze, and powder suspensions being better on stainless steel. These preliminary results reinforce the need to take into account both surface type and condition before selection of the most effective fingermark visualisation process and demonstrate the value of techniques such as SEM in developing a fundamental understanding of the interactions between fingermarks and surfaces.     

Community‐based restorative transitional justice in Sierra Leone

Community‐based restorative transitional justice is an important feature of peace consolidation, maximizing access to justice and facilitating reconciliation. Examining post‐conflict Sierra Leone as a case study, the author draws on existing justice practices in Sierra Leone as examples of restorative responses to war criminality. Specifically, the traditional reintegration of former male and female combatants and the emergence of a new project, ‘Fambul Tok’ are detailed. The author discusses and compares the Special Court for Sierra Leone and the Truth and Reconciliation Commission to point to gaps in transitional justice that call for community‐based restorative strategies.     

Information Conduits or Content Developers? Determining Whether News Portals Should Enjoy Blanket Immunity from Defamation Suits

News portals should be held to the same standard of liability for defamation as other news media. Internet service providers (ISPs) enjoy blanket immunity from liability for defamation under Section 230 of the Communications Decency Act, while information content providers (ICPs) might not. Some courts have indicated, however, that a defendant who participates in developing third-party content should be classified as an ICP and thus be held liable. Confusion over the difference between an ISP and an ICP is applied to the case of news portals. This study investigates to what extent news portals should enjoy immunity from liability for defamation. To determine a news portal's exposure to liability, a continuum of involvement is proposed as a standard in which liability is based on a defendant's actions and not on the medium employed. A defendant's involvement with third-party content can be classified under the four levels of the continuum, which can guide courts in deciding whether a defendant is liable. Congress should amend Section 230 to incorporate the continuum and allow courts discretion in determining whether a defendant is immune from liability.     

Family succession through adoption in the Chosun Dynasty

Using a unique data source of genealogies of upper-status families, called Bulcheonwye families, we assess how the extent of family succession through adoption changed over five centuries from 1450 to 1949 in Korea. Our analysis shows the continued increase in the share of adopted sons among total family successors up to the end of the 19th century when three out of ten family successors were adopted. The trend of the increasing role of adoption is closely related to the declining number of sons per family, suggesting that not only the rising influence of Confucian culture but also demographic changes increased the demand for adoption. Finally, our comparison provides evidence that the likelihood of achieving high social status was significantly higher among adopted sons than biological ones, suggesting that the socioeconomic potential of adopted sons could be an important factor for adoption decision.     

A survey of data sources for studies of family and population in Korean history

Compared to China and Japan, family and population studies of pre-modern Korea have not been widely available to scholars outside Korea. As a necessary step to increase scholarship in Korean historical demography, we introduce major historical materials currently available in Korea as useful for historical studies, summarizing demographic variables provided, the type of population covered, and the historical period referred in those historical materials. In particular, we focus on genealogies and household registers that provide demographic information of Korean population before the 20th century. We describe major features of those Korean materials as demographic sources, highlighting similarities and differences as compared to corresponding Chinese historical materials. Korean historical data showing their unique features, along with comparability with other East Asian data, have potential to expand the field of historical demography in East Asia.     

Normative Balance and Electoral Reform: A Finnish Puzzle and a Comparative Analysis

The Finnish electoral system has recently been changed to slightly increase proportionality, but nothing has been done to make cabinet alternatives more ‘identifiable’ before the election. This outcome poses a major puzzle for one important theoretical approach to electoral system change. This approach sees normatively ‘unbalanced’ systems as vulnerable to reform and would have expected a significant increase in the pre-electoral identifiability of competing cabinet options. The article explains the Finnish case by embedding it in a comparative model of normative tradeoffs in democratic design. Based on Finnish case evidence and a statistical analysis of 100 elections in 32 democracies (from 2001 to 2011), the article argues that the type of democracy exemplified by Finland is not normatively unbalanced. In particular, the lack of pre-electoral identifiability is compensated for by an unconstrained multidimensionality of partisan preferences. While it may be true that normatively balanced designs are more stable, there is more than one way to be balanced.     

Reinventing government: a critique from an institutional perspective(1)

This paper critically examines the recent reinventing government movement from an institutional perspective, focusing on principal-agent problems in management and political contexts of public agencies. Based on this perspective, it analyzes the problems and prospects of the National Performance Review in the United States and suggests that an institutional perspective can prove useful in redesigning government--not by achieving a single set of insights common to all contexts, but rather by focusing attention to particular situations and institutional contexts.