Analysis of Δ-tetrahydrocannabinol in oral fluid samples using solid-phase extraction and high-performance liquid chromatography–electrospray ionization mass spectrometry

An analytical method using solid-phase extraction (SPE) and high-performance liquid chromatography–mass spectrometry (LC–MS) has been developed and validated for the confirmation of Δ⁹-tetrahydrocannabinol (THC) in oral fluid samples. Oral fluid was extracted using Bond Elut LRC-Certify solid-phase extraction columns (10 cm³, 300 mg) and elution performed with n-hexane/ethyl acetate. Quantitation made use of the selected ion-recording mode (SIR) using the most abundant characteristic ion [THC + H⁺], m/z 315.31 and the fragment ion, m/z 193.13 for confirmation, and m/z 318.00 for the protonated internal standard, [d₃-THC + H⁺]. The method proved to be precise for THC, in terms of both intra-day and inter-day analyses, with coefficients of variation less than 10%, and the calculated extraction efficiencies for THC ranged from 76 to 83%. Calibration standards spiked with THC between 2 and 100 ng/mL showed a linear relationship (r² = 0.999). The method presented was applied to the oral fluid samples taken from the volunteers during the largest music event in Portugal, named Rock in Rio-Lisboa. Oral fluid was collected from 40 persons by expectoration and with Salivette^®. In 55% of the samples obtained by expectorating, THC was detected with concentration ranges from 1033 to 6552 ng/mL and in 45% of cases THC was detected at concentrations between 51 and 937 ng/mL. However, using Salivette^® collection, 26 of the 40 cases had an undetectable THC.     

Book reviews

Turkey in the Middle East By Philip Robins. Pinter for the Royal Institute of international Affairs. 1991.130 pp. £22.50. ISBNO 86187 198 7. PBk £8.95. ISBN 0 86187 1995.

Hitler Slept Late and other blunders that cost him the war By James P. Duffy. London: Praeger. 1991.176pp. £17.50.

Alliance within the alliance: Franco‐German Military Cooperation and the European Pillar of Defense By David G. Haglund. Boulder: Westview Press, 1991. 213 pp.

Homeward Bound? Allied Forces in the New Germany Edited by David G. Haglund and Olaf Mager. Boulder: Westview Press, 1992. 299 pp. £24.95

Avoiding War: Problems of crisis management By Alexander L. George (ed.), Westview Press, 1991. 590 pp. £16.95.

The Future of NATO: Facing an Unreliable Enemy in an Uncertain Environment By S.N. Drew et al. Praeger Publishers, New York, 1991. pp. 206.

Parliament and international relations Edited by Charles Carstairs and Richard Ware. Milton Keynes: Open University Press, 1991. 195 pp. £12.99 (paperback)     

Under Two Flags: Symbolic Voting in the State of Mississippi

Participants in a specialelection held in the State of Mississippion April 17, 2001, voted overwhelminglyagainst changing the design of the state'sflag, which incorporates a symbol of theConfederacy. The determinants of voting onthe flag are analyzed and turnout rates inApril 2001 are compared with those forrecent gubernatorial and presidentialelections. We find that the flag votedivided Mississippians sharply along linesof race, class and political ideology. Akey empirical implication is that voterpositions in issue space tend to be morepolarized when political choices haveexpressive as opposed to instrumentalconsequences.     

Corporate governance in Germany: The changing role of the banks

The article analyses the different channels ‐ industrial stakes, supervisory board mandates, proxy voting ‐ by which German banks can exert influence on industrial companies. The central thesis is that even where the banks have such influence they do not dominate the companies. A recent empirical study on the effects of the alleged bank dominance over industrial companies with detrimental effects on their performance is shown to contain major methodological mistakes. The relationship between banks and industry is undergoing some distinct changes. Banks have substantially reduced their industrial stakes as well as their representation on supervisory boards, which underlines that they are not striving for industrial leadership. Despite a clear trend in the German corporate sector to pay increasing attention to shareholder value and to provide more transparency in accounting, it seems premature to expect the German capital market, including the corporate governance system, to incorporate fully the Anglo‐Saxon model in the immediate future.     

Schranken des Rechts zur Pflichtteilsminderung nach § 773a Abs 3 ABGB

Das Recht auf Pflichtteilsminderung steht nach § 773a Abs 3 ABGB nicht zu, wenn der Erblasser die Ausübung des Rechts auf pers?nlichen Verkehr mit dem Pflichtteilsberechtigten grundlos abgelehnt hat. Im Rahmen dieser Bestimmung sind minderj?hrige und erwachsene Kinder gleich zu behandeln. § 773a Abs 3 ABGB ist auch auf solche Testamente anzuwenden, die vor dem 1. 7. 2001 (Inkrafttreten dieser Bestimmung) verfasst worden sind. Zum Entfall des Minderungsrechts führt aber nur ein Verhalten, das der Erblasser nach dem 1. 7. 2001 gesetzt hat. Für Dauersachverhalte (hier: das Verh?ltnis Eltern und Kind) gelten die Rechtsfolgen eines neuen Gesetzes ab seinem Inkrafttreten; mangels abweichender übergangsregelung ist der Teil des Dauertatbestands, der in den zeitlichen Geltungsbereich des neuen Gesetzes reicht, nach der neuen Rechtslage zu beurteilen.     

Bewilligung der Adoption: Zustimmung der Mutter erforderlich, deren Aufenthalt bei Beschlussfassung erster Instanz bekannt ist

Die Voraussetzungen für die Bewilligung der Adoption sind nach der Sach- und Rechtslage im Zeitpunkt der Beschlussfassung erster Instanz zu beurteilen. Auch der Kreis der Zustimmungsberechtigten bestimmt sich nach diesem Zeitpunkt; es ist kein Grund erkennbar, die Voraussetzungen für den Entfall des Zustimmungserfordernisses nach § 181 Abs 2 ABGB nach einem anderen Zeitpunkt zu beurteilen. Bis zu diesem Zeitpunkt kann sich auch eine Mutter, die keine ausdrückliche Zustimmung zur Adoption erteilt hat und mehr als sechs Monate unbekannten Aufenthaltes war, gegen diese aussprechen. Vor Bewilligung der Adoption besteht kein rechtlich geschütztes Vertrauen auf deren Zustandekommen. Der mit dem Bewilligungsverfahren notwendigerweise verbundene Schwebezustand muss von den Wahleltern wegen der grundrechtlich geschützten Rechtsstellung der leiblichen Eltern hingenommen werden. Trotz Fehlens einer ausdrücklichen Rsp des OGH zu einer konkreten Fallgestaltung liegt dann keine erhebliche Rechtsfrage vor, wenn das Gesetz selbst eine eindeutige Regelung trifft oder ein Streitfall trotz neuer Sachverhaltselemente bereits mit Hilfe vorhandener Leitlinien h?chstgerichtlicher Rsp gel?st werden kann.     

Discovering the Dark Side of Power: The Principal’s Moral Hazard in Political-Bureaucratic Relations

Principal agent (PA) is among the most prominent concepts for analyzing the relationship between politics and bureaucracy. Nonethelesss, the inherent bias of PA scholars to attribute moral hazard almost exclusively to the agent, usually referred to as “bureaucratic drift”, requires re-examination. Building on the spare literature in which moral hazard of the principal is considered, this paper provides empirical evidence for a neglected aspect of the PA concept. Three cases of German regulatory agencies responsible for drug control, financial services and rail safety are analyzed in critical situations which were largely perceived as bureaucratic failures. The analysis reveals that a good deal of these failures, ranging from negligence to suppressing crucial information, has to be attributed to the political principal. This is called the dark side of power because the intention is to shift blame or to dodge political responsibility. Turning conventional PA reasoning upside down, the conclusion is that the principal’s moral hazard should be considered more routinely as a potential explanation for political-bureaucratic interactions.