Analysis of artificially degraded DNA using STRs and SNPs--results of a collaborative European (EDNAP) exercise

Recently, there has been much debate about what kinds of genetic markers should be implemented as new core loci that constitute national DNA databases. The choices lie between conventional STRs, ranging in size from 100 to 450 bp; mini-STRs, with amplicon sizes less than 200 bp; and single nucleotide polymorphisms (SNPs). There is general agreement by the European DNA Profiling Group (EDNAP) and the European Network of Forensic Science Institutes (ENFSI) that the reason to implement new markers is to increase the chance of amplifying highly degraded DNA rather than to increase the discriminating power of the current techniques. A collaborative study between nine European and US laboratories was organised under the auspices of EDNAP. Each laboratory was supplied with a SNP multiplex kit (Foren-SNPs) provided by the Forensic Science Service, two mini-STR kits provided by the National Institute of Standards and Technology (NIST) and a set of degraded DNA stains (blood and saliva). Laboratories tested all three multiplex kits, along with their own existing DNA profiling technique, on the same sets of degraded samples. Results were collated and analysed and, in general, mini-STR systems were shown to be the most effective. Accordingly, the EDNAP and ENFSI working groups have recommended that existing STR loci are reengineered to provide smaller amplicons, and the adoption of three new European core loci has been agreed.     

Serum concentrations of cardiac troponin T in sudden death

Ischemic heart disease is the most common cause of sudden death of natural causes in most western countries. By autopsy, there may be no gross or histologic evidence of acute myocardial damage unless the patient survived for several hours following the event. Cardiac troponin in serum has become the recommended biochemical marker for myocardial injury in the clinical setting. We performed a prospective study on 102 autopsied subjects at the Central Hospital of Rogaland, Stavanger, Norway. Femoral blood was sampled for subsequent analysis of cardiac troponin T (cTnT). In the subjects with morphologic evidence of recent myocardial injury (n = 34), the mean serum cTnT level was 1.95 microg/L compared with 0.16 microg/L in the subjects with a noncardiac cause of death (n = 35) and 0.61 microg/L in the group with probable sudden cardiac death without morphologic signs of acute myocardial injury (n = 33). The observed differences in mean serum cTnT levels between the groups were statistically significant (P < 0.0001). These data suggest that elevated postmortem serum concentration of cTnT reflects ongoing myocardial damage and may support a diagnosis of cardiac-related death in cases associated with sparse or inconclusive morphologic findings postmortem.     

The role of donors: how to combine sector programme support with devolution? A comment from a practitioner to James Wunsch: ‘decentralization,local governance and “recentralization” in Africa’

In commenting on ‘Decentralization, Local Governance and ‘Recentralization’ in Africa’ (Wunsch, 2001 ), this article concurs with the general thesis of Wunsch that the actual implementation as distinct from the rhetoric of decentralization in Africa has featured lingering central retention of power and resources and that genuine local control over important services and investments remains elusive. However, there is evidence that this is not invariably the case and that donors may have decisive roles to play in encouraging local assertiveness in the medium term in providing leverage for change through budget support and technical assistance to civic education, training local councillors, monitoring local government elections and encouraging local government associations to put to the test the national commitment to genuine local governance. These roles include helping to ensure the transparency of central transfers and, as in Uganda and Malawi for example, assisting with the development of intermediary fiscal mechanisms in this regard. Learning from such promising experiences will be vital in nurturing the longer term optimism heralded by Wunsch. Copyright © 2002 John Wiley & Sons, Ltd.     

Is Small Still Flexible? An Evaluation of Recent Trends in Danish Politics

How has Denmark been able to adjust its economic and industrial policies in an era of major changes in the international economy? The article gives a survey of the last 10 years, especially more recent years. Before 1986 wage policy and public-expenditure policy were dominant. Since then they have been supplemented by a new structural policy to increase the level of technology, to improve education and research and to change the composition of Danish exports as far as products and markets are concerned. The adjustment of policies has taken place in a stable multi-centred political system. The process has been characterized by institutionalized campaigning, moulding of interests and mobilization of compromises and mutual understanding. The capacity for flexible adjustment seems to originate from the stability of the political system. Likewise, uncertainty and instability seem to weaken the capacity for political flexibility. During the last two years the transformation of the elite consensus into state programmes and administrative decision-making has been hampered and the whole structural policy approach has been challenged by a neoliberal alternative. This is mainly due to an extraordinary parliamentary stalemate in a situation of extreme minority parliamentarism.     

C. Reviews and notes: bibliographies and works of reference

THE CONCISE ENCYCLOPÆDIA OF ISLAM. By CYRIL GLASSÉ. London, Stacey International, 1989. 472pp. Ills., maps, plans. £30.00

THE NEAR EAST NATIONAL UNION LIST. Volume 1. Compiled by DOROTHY STEHLE, under the direction of GEORGE N. ATIYEH. Washington, Library of Congress, 1988. ix, 867pp. USS 47.00.

MUDEJARES: REPERTORIO BIBLIOGRAFICO. Compiled by PAZ FERNANDEZ. (Cuadernos de la Biblioteca Islámica ‘Félix María Pareja’, 18.) Madrid, Instituto Hispano‐Árabe de Cultura, 1988. iii, 42pp.

INFORMATIONS BIBLIOGRAPHIQUES. I'LAMAT BIBLIYUGHRAFIYYA. 3 et 4–1986; 1 et 2–1987. Tunis, Bibliothèque Nationale, Service des Dépots et des Publications/Dar al‐Kutub al‐Wataniyya, Maslahat al‐Ida’ wa‐1‐Nashr, 1987. 45 + 23; 49 + 46pp.

L'ÉCONOMIE DES PAYS ARABES: PRÉSENTATION THÉMATIQUE DES TRAVAUX DE LA PÉRIODE 1979–1984. By CHANTAL BERNARD. (Cahiers du C.R.E.S.M., 20.) Paris, Centre National de la Recherche Scientifique, 1988. 156pp. FF 90.‐.

SYRIA. Compiled by IAN J. SECCOMBE. (World Bibliographical Series, 73.) Oxford, Clio Press, 1987. xxxii + 341pp. £45.00.

MALTA. Compiled by J.R. THACKRAH. (World Bibliographical Series, 64.) Oxford, Clio Press, 1985. xviii, 153pp. Map. £23.50.

BIBLJOGRAFIJA NAZZJONALI TA’ MALTA. MALTA NATIONAL BIBLIOGRAPHY, 1983–1987. Valletta, National Library of Malta, 1984–1988. 5 volumes. 41; 60; 59; 64; 76pp. Each LM 1.50 or US $9.00 (incl. air mail postage).

MELITENSIA: BOOKS IN PRINT 1985. Valletta, Sapienzas, 1985. 55pp.

ARABIC LANGUAGE TEACHING IN THE UNITED KINGDOM: 1988 DIRECTORY. Compiled by DIONISIUS A. AGIUS. [Leeds,] Folia Scholastica, 1988. 36pp. £2.50.

QUR'ANS OF THE MAMLUKS. By DAVID JAMES. London, Alexandria Press in association with Thames and Hudson, 1988. 270pp. 170 illustrations (80 in colour). 1 map. £35.00.

CALLIGRAPHIE ISLAMIQUE, TEXTES SACRES ET PROFANES. ISLAMIC CALLIGRAPHY, SACRED AND SECULAR WRITINGS. By DAVID JAMES & others. Geneva, Musée d'Art et d'Histoire and Treasures of Islam, 1988. 200pp. Colour illus.

KAYF NU'ALLIM AL‐KHATT AL‐'ARABI. By MA'RUF ZURAYQ. Damascus, Dar al‐Fikr, 1407/1987 (2nd edition, reprinted from the 1985 edition). 150pp. 51 illustrations. US$ 2.50.

IMAGES OF WOMEN: THE PORTRAYAL OF WOMEN IN PHOTOGRAPHY OF THE MIDDLE EAST 1860–1950. By SARAH GRAHAM‐BROWN. London, Quartet, 1988. 288pp., 216 b/w ills. £22.50.     

B. Reviews: bibliographies and works of reference

INDEX DES HITAT: INDEX ANALYTIQUE DES OUVRAGES D'IBN DUQMAQ ET DE MAQRIZI SUR LE CAIRE. Volumes I‐III. By AHMAD ‘ABD AL‐MAJID HARIDI. (Textes arabes et études islamiques, XX.) Cairo, Institut François d'Archéologie Orientale, 1983–84. 3 vols. 463; 221; 389 pp.

WESTERN SAHARA: A COMPREHENSIVE BIBLIOGRAPHY. Compiled by LYNN F. SIPE. (Garland Reference Library of Social Science, 178). New York, Garland Publishing, 1984. 418pp. One map (based on United Nations map No.2547/Rev 2).

BAHRAIN. Compiled by P.T.H. UNWIN. (World Bibliographical Series. 49). Oxford & Santa Barbara, Clio Press, 1984. xxxii, 265pp. Map. £33.00.

CATALOGUE COLLECTIF DES OUVRAGES EN LANGUE ARABE ACQUIS PAR LES BIBLIOTHEQUES FRANÇAISES, 1952–1983. Préparé par GEORGES HADDAD et MOHAMMED SAID... München, K.G. Saur, 1984. 4 vols. 2667pp. DM 800.—

ARAB AND ISLAMIC INTERNATIONAL ORGANIZATION DIRECTORY 1984/85. Edited by UNION OF INTERNATIONAL ASSOCIATIONS. (Guides to International Organizations, no.2.) München, K.G. Saur, 1984. 484pp. DM 248,‐.

INTERNATIONAL DIRECTORY OF ISLAMIC CULTURAL INSTITUTIONS. Prepared by ACAR TANLAK and AHMED LAJIMI. Istanbul, Organisation of Islamic Conference, Research Centre for Islamic History, Art and Culture, 1405/1984. (Distributed in the U.K. by Kegan Paul International.) 337pp.

SUFI SYMBOLISM. By JAVAD NURBAKHSH. (Nurbakhsh Encyclopedia of Sufi terminology, vol.I.) London, Khaniqahi‐Nimatullahi Publications, 1984. 228pp. £15.00

IRAN: POLITICS AND GOVERNMENT UNDER THE PAHLAVIS. AN ANNOTATED BIBLIOGRAPHY. By DARIUSH GITISETAN. Metuchen, Scarecrow Press, 1985. xi, 201pp. £15.00.

GUIDE TO REFERENCE BOOKS FOR ISLAMIC STUDIES. By C.L. GEDDES. (Bibliographic Series, No.9.) Denver, American Institute of Islamic Studies, 1985. xiii, 429pp. US $45.00.

MU'JAM AL‐MU'ALLIFIN AL‐SURIYYIN FI AL‐QARN AL‐'ISHRIN. By ‘ABD AL‐ QADIR ‘AYYASH. Damascus, Dar al‐Fikr, 1985. 544pp.

WILLIAM BEDWELL THE ARABIST, 1563–1632. By ALASTAIR HAMILTON. (Publications of the Sir Thomas Browne Institute, Leiden, New series, no.5.) Leiden, E.J. Brill & Leiden University Press, 1985. 163pp. 13 plates. HFI. 46.—

BUCHWESEN IN BOSNIEN UND DER HERZEGOWINA (1800–1878). By JOZO D?AMBO. (Arbeiten und Bibliographien zum Buch‐ und Bibliothekswesen; 2.) Frankfurt am Main, Peter Lang, 1985, 231pp. 2 maps and charts. SFr. 45/US$ 19.55.

MU'JAM AL‐MUSTALAHAT AL‐MASRIFIYYA WA‐MUSTALAHAT AL‐BURSA WA‐L‐TA'MIN WA‐L‐TIJARA AL‐DUWALIYYA. LEXIQUE DES TERMES BANCAIRES: ARABE‐FRANÇAIS‐ANGLAIS. GLOSSARY OF BANKING TERMS: ARABIC‐FRENCH‐ENGLISH. By FARIDI BAZ (Freddie Baz), MAKRAM SADIR (Makram Sader) and JURJ ABI SALIH (Georges Abi Saleh). Beirut, Middle East Media. 1985. (Distributed by MEED Books, London.) 309pp.

CATALOGUE No.555: ORIENTAL MANUSCRIPTS: Offered for sale by E.J.BRILL. Leiden, E.J. Brill, 1986. 161pp. HFI. 15.‐

SHORT GUIDE TO MODERN STAR NAMES AND THEIR DERIVATIONS. By PAUL KUNITZSCH and TIM SMART. Wiesbaden, Harrassowitz, 1986. 64pp. DM 39.80.

OSMANLI ?MPARATORLUGU'NDAN GÜNÜMÜZE BELGELERLE MÜZ?K (NOTA) YAYINCILIGI (1876–1986). MUSIC PUBLICATIONS FROM OTTOMAN EMPIRE UP TODAY [sic] (1876–1986). By BÜLENT ALANER. (Belgelerle Türk Müzik Tarihi Dizisi, I.) Ankara, Anadol Yaymcilik, 1986. 99pp. 70 ills. (mostly photo‐reproductions from published sheet music).

THE PALESTINIAN PROBLEM AND UNITED STATES POLICY: A GUIDE TO ISSUES AND REFERENCES. By BRUCE KUNIHOLM and MICHAEL RUBNER. (Guides to contemporary issues, 5). Claremont (USA), Regina Books, 1986. 157pp. £16.50 (hardback); £10.45 (paperback).

ENGLISH‐ARABIC DICTIONARY OF COMPUTER TERMS. By FIRAS H. ALI London, Edward Arnold, 1986. 109pp.

ARABIC COMPUTER DICTIONARY: ENGLISH‐ARABIC, ARABIC‐ENGLISH. Compiled by MULTI‐LINGUAL INTERNATIONAL PUBLISHERS LTD. General Editor ERNEST KAY. London, Routledge and Kegan Paul, 1986. 177 + 127 pp. £30.00

AFGHANISTAN: AN AMERICAN PERSPECTIVE. A GUIDE TO U.S. OFFICIAL DOCUMENTS AND GOVERNMENT‐SPONSORED PUBLICATIONS. By JULIAN W. WITHERELL. (Near Eastern Series, no. 3.) Washington, Library of Congress, 1986. xiii, 158pp. U.S. $5.00.

A GUIDE TO ‘DOCUMENTS FROM THE NEST OF SPIES.’ By GIORGIO VERCELLIN. (Occasional paper, 26.) New York, Afghanistan Forum, 1986. 29pp.     

D. Reviews and notes: bibliographies and works of reference

RANNYAYA PERSIDSKAYA LEKSIKOGRAFIYA, XI‐XV vv. [Early Persian lexicography, 11th‐15th centuries]. By S.I. BAEVSKII. Moscow, Nauka, 1989. 166pp.

PERIODICALS IN TURKISH AND TURKIC LANGUAGES: A UNION LIST OF HOLDINGS IN U.K. LIBRARIES. Edited by MUHAMMAD ISA WALEY. Oxford, Middle East Libraries Committee (U.K.), 1993. 95pp. £20.‐

DIRECTORY OF TURKISH STUDIES 1993. Edited by MALCOLM WAGSTAFF and CHRISTINE WOODHEAD. [Southampton,] Turkish Area Study Group, 1993. 19pp. £2.00

LEBANON. Compiled by C.H. BLEANEY. (World Bibliographical Series, 2.) Oxford, Clio Press, 1991. xxxi, 230pp. Map. £39.00.

THE ILLUSTRATED ATLAS OF JERUSALEM. By DAN BAHAT, with C.T. RUBINSTEIN. Jerusalem & New York, Carta Israel Map and Publishing Company; English‐language Edition: Simon & Schuster, 1990. 152pp. £60.‐

DER NAHOSTKONFLIKT SEIT AUSBRUCH DER INTIFADA: EINE AUSWAHL BIBLIOGRAPHIE / THE ARAB‐ISRAELI CONFLICT SINCE THE OUTBREAK OF THE INTIFADAH: A SELECTED BIBLIOGRAPHY. By IN‐GEBORG OTTO and MARIANNE SCHMIDT‐DUMONT. (Biblio, 17.) Hamburg, Deutsches Ubersee‐Institut, 1990. ix, 98pp. DM 15.‐

THE INTIFADA: THE PALESTINIAN UPRISING IN THE WEST BANK AND GAZA STRIP: A BIBLIOGRAPHY OF BOOKS AND ARTICLES 1987–1992. By HALA KALEH and SIMONETTA CALDERINI. (Middle East Libraries Committee Research Guides, 6.) Oxford, Middle East Libraries Committee, 1993. 59 + 10 + 50pp. [Arabic title: al‐INTIFADA. AL‐INTIFADA AL‐FILASTINIYYA FI AL‐ARADI AL‐MUHTALLA: BIBLIYUGHRAFIYYA LI‐L‐KUTUB WA‐AL‐MAQALAT i987–1992. By HALA KAYLA wa‐SIMUNITA KALDIRINI.] £25.‐

ALGERIEN‐BIBLIOGRAPHIE: PUBLIKATIONEN AUS DER BUNDES‐REPUBLIK DEUTSCHLAND, ÖSTERREICH, UND DER SCHWEIZ, 1962–1989. Compiled by ERNSTPETER RUHE. Wiesbaden, Harrassowitz, 1990. 181pp. DM48.‐

OPEC AND THE WORLD ENERGY MARKET: A COMPREHENSIVE REFERENCE GUIDE. By JOHN EVANS, fully revised by GAVIN BROWN. 2nd edition. Harlow, Longman Current Affairs, 1991. xxvii+749 pp. £115.‐

WHO'S WHO IN THE ARAB WORLD 1993–1994. Eleventh edition (thoroughly revised and completed). Beirut, Publitec Publications, in co‐edition with K.G. Saur, München, 1993. 978pp. £225.00.

RELIGION IN POLITICS: A WORLD GUIDE. Edited by STUART NEWS. (Longman International Reference.) Harlow, Longman, 1989. 332pp.