A light stabilizer Tinuvin 770-induced toxic injury of adult rat cardiac myocytes

Tinuvin 770/bis(2,2,6,6-tetramethyl-4-piperidinyl)sebacate is a worldwide used light stabilizer for plastic materials like polyolefins. Tinuvin 770 is a biologically active component of polypropylene tubes. Glossmann and his study group managed to extract this compound by aqueous or organic solvents from laboratory plastic tubes, and propose that Tinuvin 770 is a potent blocker of L-type Ca(2+)-channel through the phenylalkylamine and benzothiazepine-selective drug binding domains of the alpha(1) subunit of the receptor [Proc. Natl. Acad. Sci. U.S.A. 90 (1993) 9523].We examined the direct morphological effect of Tinuvin 770 in give 25nmol, 0, 30, 60, 120 minute exposure time in isolated cardiomyocytes from adult rats. Incubation of myocytes with Tinuvin resulted in a progressive decline of rod-shaped and viable cells. It was accompanied by an increase in number of hypercontracted myocytes with microbleb formation compared to control and depletion of ATP level.In summary, our results demonstrate that plasma membrane damage and hypercontraction are manifestations of Tinuvin-induced injury of isolated cardiomyocytes.     

STR data for the AmpFlSTR Profiler Plus and COfiler loci from the Maghreb (North Africa)

Allele frequencies for 13 STRs (D3S1358, vWA, FGA, D8S1179, D21S11, D18S51, D5S818, D13S317, D7S820, THO1, TPOX, CSF1PO and D16S539) included in the AmpFlSTR Profiler Plus and COfiler kits were determined for a population sample from the Maghreb (Northern Africa).     

Green multiculturalism: articulations of ethnic and environmental politics in a Colombian ‘black community’

This paper analyzes the intersection of two parallel developments that have had a curious impact on agrarian politics in Colombia: on the one hand, attempts to appropriate land for ‘green’ ends such as biofuel production, which have become ubiquitous all across Latin America, and on the other, the implementation of multicultural reforms, which in Colombia resulted in the collective titling of more than five million hectares of land for ‘black communities’. Although these two developments can be read as contradictory – with ‘green grabs’ threatening ethnic groups’ territorial rights and multicultural reforms purportedly safeguarding them – I argue that, together, they produce a unique political articulation which I term ‘green multiculturalism’.

My analysis of oil-palm cultivation in a ‘black community’ in southwestern Colombia reveals three interrelated consequences. First, I suggest that green multiculturalism produces ‘black communities’ as ‘green’ collective subjects charged not only with being wardens of nature, but also bearers of the responsibility to right environmental wrongs. Second, I note that the agrarian practices associated with oil-palm cultivation act as disciplining technologies that seek to transform local rationalities into entrepreneurial ones. Finally, I contend that these initiatives are ‘landscaping projects’ that seek to transform forms of interspecies relating.     

Rising start-up costs of voting: political inequality among first-time voters

Abstract

Research on voting behaviour stresses that whether citizens become habitual voters depends on the very first elections in their adult life. This article focuses on the increasing participation gap of first-time voters with low and high levels of resources. Looking first at 14 European countries and second at long-term dynamics in Germany, the turnout rate of first-time and older voters over time is compared. It is shown that the turnout gap has increased substantially since the 1980s. In contrast, educational differences in electoral turnout among older citizens are still comparatively small. It is argued and shown that the turnout gap among the young is due to rising ‘start-up’ costs of voting, which affect mainly those who are resource poor.