Prizes for innovation of new medicines and vaccines

This article argues that prizes can help stimulate medical innovation, control costs and ensure greater access to new medicines and vaccines. The authors explore four increasingly ambitious prize options to reward medical innovation, each addressing flaws in the current patent system. The first option promotes innovation through a large prize fund linked to the impact on health outcomes; the second option rewards the sharing of knowledge, data, and technology with open source dividends; the third option awards prizes for interim benchmarks and discrete technical problems; and the final option removes the exclusive right to use patented inventions in upstream research in favor of prizes. The authors conclude that a system of prizes to reward drug development would break the link between R&D incentives and product prices, and that such a reform is needed to improve innovation and access to new medicines and vaccines.     

Revolutionary Pathways: Leaders and the International Impacts of Domestic Revolutions

How much and in what ways do individual leaders matter for international politics? This article sheds new light on these questions by considering the consequences of domestic revolutions in international relations. We argue that revolutions have international effects due to two separate pathways, one associated with the event and one associated with the new leader’s administration. In the first pathway, a revolutionary event disrupts established relationships and perceptions, creating uncertainty both within the state and abroad. In the second pathway, revolutions put individuals into office who are more willing to challenge the status quo and who have publicly committed to a sustained shift in policies during their administration. These two distinct pathways suggest that the important question about revolutions is not whether leaders or events matter most but rather the conditions under which they matter. Consequently, we studied these pathways on three phenomena: international economic sanctions, domestic economic growth, and interstate alliances. We find that revolutionary events have a short-term negative effect on domestic economic growth, while revolutionary leaders have a long-term effect on the probability that a revolutionary state is targeted for sanctions. Both the revolutionary leader and the revolution’s immediate events alter the state’s international alliances. Our findings suggest that no single level of analysis completely dominates, and the answer depends on the outcome of interest.     

The Associations between Substance Use,Sexual Behavior,Deviant Behaviors and Adolescents’ Engagement in Sexting: Does Relationship Context Matter?

While prior research has identified multiple associations between engagement in sexting and risky behaviors, most existing studies do not take into account the contexts in which sexting occurs. The present study extends prior research by examining whether the associations between adolescents’ sexting behavior and engagement in substance use, sexual behaviors, and deviant behaviors differ depending on the relational context (within or outside of a romantic relationship) in which young people engage in sexting. Results from a survey of 1187 secondary school students (61.3% girls, n?=?728) between 16 and 22 years old (M?=?17.82 years; SD?=?0.88) revealed that sexting with a romantic partner is not a significant marker of engagement in risk behaviors. However, single youth who engage in sexting outside of a romantic relationship are more likely to report substance use, relative to their non-sexting counterparts. These findings underscore the need to use more nuanced measures to investigate sexting and for sexual education initiatives to integrate messages about substance use.     

YOUNG ADULTS' PERSPECTIVES ON DIVORCE Living Arrangements

There is increasing consensus that the perspectives of children need to be taken into account in decisions made by divorcing parents and the courts and that young adults who have lived through their parents' divorces can be an important source of information about children's perspectives. In this study, the authors assessed the perspectives of 820 college adults from divorced families on the issue of children's living arrangements after divorce. Respondents wanted to have spent more time with their fathers as they were growing up, and the living arrangement they believed was best was living equal time with each parent. The living arrangements they had as children gave them generally little time with their fathers. Respondents reported that their fathers wanted more time with them but that their mothers generally did not want them to spend more time with their fathers.     

Is Partial-Dimension Convergence a Problem for Inferences from MCMC Algorithms?

e-mail: jgill{at}wustl.edu Increasingly, political science researchers are turning to Markovchain Monte Carlo methods to solve inferential problems withcomplex models and problematic data. This is an enormously powerfulset of tools based on replacing difficult or impossible analyticalwork with simulated empirical draws from the distributions ofinterest. Although practitioners are generally aware of theimportance of convergence of the Markov chain, many are notfully aware of the difficulties in fully assessing convergenceacross multiple dimensions. In most applied circumstances, everyparameter dimension must be converged for the others to converge.The usual culprit is slow mixing of the Markov chain and thereforeslow convergence towards the target distribution. This workdemonstrates the partial convergence problem for the two dominantalgorithms and illustrates these issues with empirical examples.     

Melting Down and Scaling Up: Stabilizing Climate Change by Promoting Private Sector Technology Development

This paper will examine the role the private sector plays in researching, developing, and deploying technology that has the potential to deter or decrease the impacts of global warming. It will explore the degree to which the private sector can have an impact on global warming by focusing on four specific technologies: aircraft engines, wind turbines, solar energy, and clean coal technologies. We will compare the environmental impact of these technologies with the business case for pursuing each, specifically related to profitability and market maturity. We conclude that the business case alone is not sufficiently compelling to stimulate meaningful industry investment in these areas. Consequently, specific government involvement is needed for CO₂ reduction. This analysis will shed light on the role that government must play in order to more effectively engage potential private sector players in the global warming challenge.