Detection of the synthetic drug 4-fluoroamphetamine (4-FA) in serum and urine

4-Fluoroamphetamine (4-FA) was detected in the blood and urine of two individuals suspected for driving under the influence (DUI). The test for amphetamines in urine subjected to immunoassay screening using the CEDIA DAU assay proved positive. Further investigations revealed a 4-FA cross-reactivity of about 6% in the CEDIA amphetamine assay. 4-FA was qualitatively detected in a general unknown screening for drugs using GC/MS in full scan mode. No other drugs or fluorinated phenethylamines were detected. A validated GC/MS method was established in SIM mode for serum analysis of 4-FA with a limit of detection (LOD) of 1 ng/mL and a lower limit of quantification (LLOQ) of 5 ng/mL. Intra-assay precision was approx. 4% and inter-assay precision approx. 8%. Applying this method, the 4-FA serum concentrations of the two subjects were determined to be 350 ng/mL and 475 ng/mL, respectively. Given the pharmacological data of amphetamine, 4-FA psychoactive effects are to be expected at these serum levels. Both subjects exhibited sympathomimetic effects and psychostimulant-like impairment accordingly.     

Forensic medical characteristic of the thermal injury caused by inflammation of combustible fluids

The diagnostics of thermal injuries caused by inflammation of combustible fluids should be based on the comprehensive assessment of the results of examination of the scene of the accident, autopsy studies, forensic chemical expertise, and analysis of the circumstances of the case and/or medical documentation. Special attention should be given to the choice of adequate methods for taking samples to be used in forensic chemical studies. The assessment of thermal injuries caused by inflammation of combustible fluids must take into consideration the time and conditions under which they were inflicted (e.g. closed or open space, vertical or horizontal position, etc.).     

The cost of regulation in a decentralized context: the case of the Spanish regions

The impact of regulation on productivity is an issue that has attracted increasing interest in recent decades, as some scholars have argued that the proliferation of red tape may be the cause of slower growth rates in some western economies. Regulation (and other public instruments) has significant effects that may be either benign or harmful. Justified and well designed regulation protects consumers from potentially unsafe products, limits pollution, enhances workplace safety and contributes to public health and safety, as well as a more productive and fair society. However, an overabundance of rules or badly designed regulation can cause confusion and delay, impose unreasonable compliance costs in terms of capital investment, labour and official paperwork, retard innovation, lower productivity and, accidentally, distort incentives for private initiative. The objective of this paper is to examine the possible impact of regulatory activity in the Spanish regions over the past decade (1989–2001) on growth and productivity.     

The Reagan Deficit

This paper analyzes the U.S. federal budget deficit during the Reagan administration and its short- and longer-term consequences for the aggregate economy. While budget policies of the Reagan administration do not account for all of the increases in annual deficits or in outstanding federal debt during the Reagan era, an analysis indicates that the administration's program of tax reduction and defense spending build-up were the major sources of deficit growth after the recovery from the recession of 1981-82. For the near-term future, the legacy of the Reagan deficits includes (1) the failure of domestically owned capital formation to expand at rates comparable to our major trading partners, (2) the necessity of diverting U.S. products and income to servicing foreign creditors, and (3) the need for rates of interest and profits to be high enough to induce foreigners to retain their holdings of U.S. assets lest divestiture cause a virtual collapse in the exchange rate. The final evaluation of the impact of the Reagan deficit hinges on whether the Reagan era of high consumption prosperity proves a good trade-off with the consequences of attenuated macropolicy responses to recession, lower levels of U.S. owned capital stock, and remittances to foreign creditors.     

Sudden unexpected death associated with atlanto-occipital fusion

A case of sudden, unexplained death in a 24-year-old male is presented. There were two previous spells of loss of consciousness. There was remarkable narrowing of the foramen magnum with indentation of the medulla. The atlas was partly fused with the occipital bone and a portion of abnormal bone compromised the foramen magnum from anterior reducing its anteroposterior dimensions to 16 mm (n 25-35 mm). Close clinical examination of this area in patients with acute intermittent symptomatology, or at the time of autopsy in cases of sudden unexpected death is stressed.     

Litigation, experimentation, and reputation

This paper develops a multiple-plaintiff game with a correlation across plaintiffs' private information (damage levels). It argues that the defendant engages in experimentation to learn (or remain uninformed about) the plaintiffs' types and play tougher (or softer) in the initial case when another party may also have an interest in the suit.