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201.
A pharmacokinetic study of ethyl glucuronide in blood and urine: applications to forensic toxicology
Høiseth G Bernard JP Karinen R Johnsen L Helander A Christophersen AS Mørland J 《Forensic science international》2007,172(2-3):119-124
This pharmacokinetic study investigated the kinetics of ethanol and its metabolite ethyl glucuronide (EtG) in blood and urine during the whole time course of absorption and elimination. There are few previous studies on the kinetics of EtG in blood, and we wanted to evaluate whether such knowledge could yield valuable information regarding the time of ethanol ingestion in forensic cases, such as, for instance, drunk driving. Ten male volunteers consumed ethanol at a fixed dose of 0.5 g/kg body weight in a fasted state. Blood samples were collected for 14 h and urine samples were collected for 45-50 h after the start of drinking. EtG reached its maximum concentration (C(max)) in blood after a median of 4 h (range 3.5-5), a median of 3 h (range 2-4.5) after C(max) for ethanol. The ethanol-to-EtG ratios in blood (ethanol in g/L, EtG in mg/L) were >1 only for the first median 3.5 h (range 2.5-3.5) after drinking. EtG elimination occurred with a median half-life of 2.2 h (range 1.7-3.1 h), and the renal clearance was 8.32 L/h (median, range 5.25-20.86). The concentrations of EtG were always much higher in urine than in blood. The total amount of EtG excreted in the urine was median 30 mg (range 21.5-39.7), representing 0.017% (median, range 0.013-0.022) of the ethanol given, on a molar basis. The information from the present study may be a valuable supplement to determine the time of ethanol ingestion. For this purpose, two subsequent increasing EtG values and a high ethanol-to-EtG ratio in blood would support information of recent drinking. 相似文献
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Brendan O'Leary Bernard Grofman Jørgen Elklit 《American journal of political science》2005,49(1):198-211
Some proportional representation (PR) rules can also be used to specify the sequence in which each party in a parliament or each member in a multiparty governing coalition is given its choice about (unique) desired resources, e.g., "indivisible goods" such as cabinet ministries or executive positions, thus providing an algorithmic method for determining "fair" allocations. Divisor rule sequencing using the d'Hondt method was recently used to determine the ten cabinet positions in the Northern Ireland Executive Committee created under the 1998 Belfast ("Good Friday") Agreement; and such sequential allocation procedures have been used in some Danish municipal governments, and for determination of committee chairs in the European parliament. Here we examine in some detail the procedures used in Northern Ireland and Denmark, with a focus on special features such as the option in Denmark to form post-election alliances. 相似文献
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Bernard Flynn 《群星:国际评论与民主理论杂志》2002,9(3):436-444
Book reviewed in this article:
Claude Lefort, La Complication: Retour Sur Communisme 相似文献
Claude Lefort, La Complication: Retour Sur Communisme 相似文献
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