Good and Evil in Indian Buddhism: The five Sins of Immediate Retribution

Indian Buddhist sources speak of five sins of immediate retribution: murder of mother, father, an arhat, drawing the blood of a buddha, and creating a schism in the monastic community. This category provides the paradigm for sinfulness in Buddhism. Yet even these sins can and will, be expiated in the long run, demonstrating the overwhelmingly positive nature of Buddhist ethics     

Ethics at Phase 0: Clarifying the Issues

The Food and Drug Administration (FDA) and the European Agency for the Evaluation of Medicinal Products (EMEA) recently issued documents encouraging sponsors to consider microdose testing before launching Phase I trials, and many commentators predict that such methodologies will be applied more routinely in drug development. However, exploratory testing has provoked several ethical criticisms. Skeptics question the value and validity of microdose trials, and whether they present a reasonable balance of risks and benefits for subjects. Another major criticism is that such studies serve mainly commercial ends. The present article explores these and other ethical concerns for studies conducted in the oncology setting. It concludes that microdosing is not inconsistent with prevailing practices in Phase I research, and that in principle, such studies could strengthen the ethical basis for Phase I trials by providing them better evidentiary justification.     

The Alaska Permanent Fund: Politics and Trust

Trust funds are a particular way of governing resource flows. Governments use trust funds to bind policy decisions of future actors and remove resource flows from budget competition. The state of Alaska removed a portion of its oil revenues from political competition through the creation of the Alaska Permanent Fund. A unique feature of the Fund is that it pays annual dividends to Alaskan citizens, thus creating a citizen stake in the management of the Fund. Through this framework Alaskans have successfully protected a significant stream of revenue ($21 billion) from political demands.     

The Recall of MPs Act 2015: Petitions,Polls and Problems

Under the terms of the Recall of MPs Act 2015, there have been three recall petitions brought against MPs who have committed misconduct. The outcomes have been variable. The first petition failed to attract enough signatures to trigger a by‐election. The second led to the unseating of the MP, who declined the opportunity to stand in the subsequent by‐election. The third led to the removal of the MP and an unsuccessful candidature to regain his seat at the by‐election. Variation has not been confined to outcomes. There have been differences in how the legislation has been implemented—in terms of the ease of access of constituents to the recall petition. This article suggests that in the interests of fairness and transparency, there is a strong case for adjusting the legislation to ensure national standardisation of local implementation.