Enantiomeric separation of methamphetamine and related analogs by capillary zone electrophoresis: intelligence study in routine methamphetamine seizures

A method for simultaneous enantiomeric separation of ephedrine, pseudoephedrine, and methamphetamine (MA) in a single run by simple capillary zone electrophoresis (CZE) with beta-cyclodextrin as a chiral selector is described. The effects of the buffer pH, phosphate concentration, beta-cyclodextrin concentration, voltage and temperature on the peak resolution were examined. Good enantiomeric resolution was attained for each analyte under our optimized conditions: 15 mM beta-cyclodextrin, 300 mM NaH2PO4 at pH 2.5 with an uncoated capillary (64.5 cm x 50 microm), applied potential at 20 kV and temperature at 30 degrees C. Ultraviolet (UV) detection at a fixed wavelength (200 nm) was employed using a diode array detector. Using phentermine as an internal standard, migration times for all analytes are reproducible within 0.16% for intra-day and 0.6% for inter-day runs. Application of this method to the analysis of confiscated drugs is discussed.     

Death resulting from ruptured cerebral artery aneurysm: 219 cases

To characterize the demographics of ruptured cerebral artery aneurysm as a cause of death and to examine the effect of improved diagnostic and therapeutic techniques on the incidence of sudden death associated with the condition, the authors reviewed 219 autopsies performed at the Dallas County Medical Examiner's Office between 1977 and 1997 in which the cause of death was ruptured cerebral artery aneurysm. Ruptured cerebral artery aneurysms accounted for 1.5% of 15,033 natural deaths and 0.4% of all deaths (45,492) followed by autopsy during this period. The majority (56%) of cases occurred in females, with Caucasian females composing the largest group (38%). Seventy-seven percent of cases occurred in individuals between the ages of 31 and 70 years, with the highest concentration in the 41- to 50-year decade (29%). The most common location for ruptured aneurysms was the middle cerebral artery distribution (39%). Multiple aneurysms occurred in 22 (9.1%) cases. Other factors, such as medical history, coexisting disease, symptoms, activity at onset of symptoms, survival time, and toxicology results are also presented. Compared with literature reports before 1980, when ruptured cerebral artery aneurysms were reported as the cause of death in approximately 4% to 5% of sudden natural deaths, the results of this study suggest that despite improved diagnostic and therapeutic techniques during the past two decades, morbidity and mortality from ruptured aneurysms remain a significant health problem.     

全面履行党章赋予党的纪检机关的职责

职责和任务是《党章》赋予党的纪检监察机关的使命,全面履行《党章》赋予的职责和任务是提高党的执政能力、巩固党的执政地位的重要保证,是党的纪检监察部门为党的中心工作服务的内在要求,是建设社会主义和谐社会的客观需要,是建立健全惩治和预防腐败体系的迫切需要;党的纪检监察部门应站在时代和历史的高度认识《党章》赋予的职责和任务,着力提升个体素质和整体能力,增强纪律观念和法制观念;当前,理顺党的纪检机关的领导体制,是党的纪检监察机关全面履行《党章》赋予其职责的重要保证。     

韩国政府绩效评估及其对中国的借鉴意义

20世纪90年代,韩国政府启动了以创建廉价、高效和服务型政府为目标的行政改革。为推动行政改革和提高政府绩效,韩国政府开展了一系列绩效评估的实践,包括成立政府经营诊断委员会、加强政府绩效审计、推行制度评估和以目标管理为基础的公务员绩效评估制度以及制定实施政府绩效评估框架法案等。韩国政府绩效评估对我国政府绩效评估制度建设有重要的借鉴意义:要把政府绩效评估与行政改革结合起来;提高公民对绩效评估的参与度;要重视对公务员个人的绩效评估;绩效评估要与管理模式相适应;绩效评估要制度化和规范化。     

“三农”政策执行中的障碍及克服路径

现阶段我国“三农”政策执行的障碍主要表现在:基层政府执行“三农”政策不力;农民表现被动;所需物质基础不牢固,等等。究其原因,主要在于作为政策执行的主体——基层政府有其内在局限性,农民的素质和组织化程度还不是很高,政策执行所需资源不足,政策执行机制存在弊端等。为此,要选择合适的路径来克服这些障碍性因素。     

Systems Ideologies and Street-Level Bureaucrats: Policy Change and Perceptions of Quality in a Behavioral Health Care System

This article examines the stability of street-level bureaucrats' negative perceptions regarding a newly implemented managed care system on quality of care and service delivery in a publicly funded behavioral health care system. Overall findings indicate that the generally negative perception of managed care did not differ between staff in the two programs, indicating a weak effect on attitudes of frontline workers. More proximal variables to the caregiver, such as service type and job title, show more influence on attitudes. The conclusion discusses the implications of these findings for practicing administrators and academic researchers.     

和谐校园建设中的管理机制创新

构建和谐校园是高校肩负的特殊历史使命。高校管理机制创新在和谐校园建设中具有十分重要的意义。为实现建设和谐校园的目标,高校管理机制要从以下六个方面进行创新:创建以人为本的柔性管理机制、公开公平的校务运行机制、诚实守信的道德约束机制、流动开放的人才聚集机制、充满活力的创新发展机制、安定有序的校园稳定机制等。     

我国当代社会泛政治化因素分析

我国当代社会具有明显的“泛政治化”倾向。“泛政治化”是一种缺乏政治理性的行为,它妨碍了正常的政治发展,使人们对社会问题不能做出实质的理解和处理,也使社会功能难以正常发挥,还常常带来政治冷漠。我们应当摈弃“泛政治化”的思维模式,构筑政治的理性主义,按照社会发展的规律来处理政治、经济、文化、体育、司法、教育等等的关系,以积极理性的心态来开展政治参与。