Extraction and isolation of cannabinoids from marijuana seizures and characterization by 1H NMR allied to chemometric tools

Marijuana, a drug derived from the Cannabis sativa L. plant, is the world's most consumed illicit drug. In this paper, a total of 156 marijuana samples seized in the state of Espírito Santo (ES), Brazil were studied and analysed by proton nuclear magnetic resonance (¹H NMR) spectroscopy to identify the major cannabinoids present. A crude extract of all samples was purified using high performance liquid chromatography so that these compounds could serve as reference substances. Nine fractions were obtained and analysed by ¹H NMR and gas chromatography–mass spectrometry (GC–MS), with five presented cannabinoids. ?⁹-THC (Δ⁹-trans-tetrahydrocannabinol), ?⁹-THCA (?⁹-tetrahydrocannabinolic acid), ?⁸-THC (?⁸-tetrahydrocannabinol), 11-hydroxycannabinol, CBV (cannabivarin), and CBN (cannabinol) were found, and their chemical structures were confirmed by GC–MS. The latter compound was obtained with high purity (≈100%), while the others were obtained as less complex mixtures with purity higher than 75% (except for Δ⁸-THC). Principal component analysis (PCA) was used on the ¹H NMR spectra of the 156 samples, and it was found that the samples were grouped according to the months, differentiating into two groups (from July 2014 to January 2015 and from February 2015 to July 2015), where non-grouping was observed from four macro-regions of the ES state (North, Central, Metropolitan, and South). The chemical profile of the seized samples was correlated to the ¹H NMR spectrum of an isolated CBN sub-fraction, in which the group formed by samples seized in the year 2015 presented lower CBN content in the chemical composition. From the PCA score plot, two groups of samples were confirmed using the partial least squares discriminant analysis and orthogonal projections to latent structures classification methods.     

An Exploratory Framework for Community-Led Research to Address Intimate Partner Violence: a Case Study of the Survivor-Centered Advocacy Project

This case study discusses the Survivor-Centered Advocacy (SCA) Project, a community-based participatory research (CBPR) project that convened anti-violence advocates from culturally specific communities to design and implement research. The project used a unique approach to build grassroots research capacity and center survivors of intimate partner violence from historically marginalized communities. This approach coalesced into the creation of an exploratory Community-Led Research (CLR) framework that incorporated trauma-informed, research justice and language justice principles. The CLR framework responded to community members’ desire to lead, rather than simply participate in, the research process. As a result, five studies were designed and executed by practitioners turned community-based researchers, most of whom had never before engaged in research, except as subjects. The CLR framework integrated the skills and experiences of community-based and external researchers, and led to high levels of engagement, rich data, more equitable research processes and innovative research projects.     

A cross-national analysis of policies affecting innovation diffusion

Innovation diffusion is important for both firms’ profitability and countries’ economic growth. For these reasons, policies that aim to reduce the main barriers to innovation diffusion are a relevant issue on the agenda of most policy makers. Although the importance of this topic is widely recognized, few studies explore public policies that aim to enhance innovation diffusion. This article attempts to fill this literature gap. Specifically, the study aims to clarify the role of policy makers in promoting new technology diffusion, to identify the barriers that affect the process of innovation diffusion and that are relevant for public policy makers and to analyze potential policies to overcome the main barriers to the diffusion of new relevant technologies. This study shows that public policies must simultaneously address the most relevant barriers to the diffusion of a new technology to be effective. Focusing on only specific barriers by developing policies with a too narrow scope may lead to poor results. The study explores a topic that is almost neglected in the innovation management literature. On the one hand, the article provides a conceptual framework for analyzing public policies. On the other hand, it proposes an overview of the repertoire of policies that policy makers can use to overcome the most relevant barriers to the diffusion of a new technology. In doing so, it also contributes to the debate about the role of the policy maker in the process of innovation development and diffusion.     

Population data on 11 Y-chromosome STRs from Guiné-Bissau

The forensic value of Y-STR markers in Guiné-Bissau was accessed by typing of 215 males. Allele and haplotype frequencies, determined for loci DYS19, DYS389-I, DYS389-II, DYS390, DYS391, DYS392, DYS393, DYS437, DYS438, DYS439 and the duplicated locus DYS385, are within the limits of variation found in other populations south of the Sahara. The level of discrimination achieved is Guineans is higher than for European or other African populations with comparable data. The haplotype diversity of 0.9995 is reduced to 0.9981 when the minimal haplotype is considered thus revealing the importance of increasing the number of typed loci.     

Die demokratische Differenz zwischen besitzindividualistischen und kommunitären Eigentumsgesellschaften

Ownership is a central institution of modern societies, underlying the latter’s differentiation into different functional spheres. The article attempts to systematically assess the consequences of this institution for the political relationship to the world as well as for the character of democratic action. It asks which type of ownership is more, and which is less conducive to the democratization of the political community. It is argued that the increasingly frequent crises of contemporary democracies that can be noticed can neither be understood nor remedied without considering the conflictual influence exerted on the political process by possessive individualist ownership societies. This is because the latter, by inducing indifference and patterns of antagonistic domination, tend to undermine the conditions for democratic interaction. As an alternative, the article outlines the contours of a communitarian ownership society based on economic ownership where ownership is understood as a relationship of caring self-efficacy – thus only allowing democracies to live up to their own ambitions.     

Social(ist) engineering. Taming the devils of the Polish Bieszczady

This article explores the background of social engineering in the Bieszczady in the 1950s and 1960s, when a revolutionary political leadership ventured to impose a new socialist order in an area ravaged by war and ethnic cleansing. The article addresses two questions: first, what were the conditions that resulted in the failure of socialist engineering in the Bieszczady, and second, what were the consequences of this failure for relationships at the local level? One thesis put forward is that the relative weakness of the Polish state vis-à-vis the local setting left plenty of room for local residents to develop a dynamic social order of their own.     

Scholarship and intelligent discussion

‘A book may be good for nothing; or there may be onlyone thing in it worth knowing; are we to read it all through?’(Samuel Johnson) This section is dedicated to the review ofideas, articles, books, films and other media. It will includereplies (and rejoinders) to articles, the evaluation of newideas or proposals, and reviews of books and articles both directlyand indirectly related to intellectual property law.

Intellectual Property Rights and the EC