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This article reviews four areas of pediatric research in which we have identified questionable levels of allowable risk, exceeding those foreseen by the Commission. They are the following: (1) the categorization of increasingly risky interventions as minimal risk in a variety of protocols; (2) the increasing number of applications for federal panel review of research not otherwise approvable because of higher projected risk levels; (3) research on asymptomatic at risk children; and (4) the inclusion of children and adolescents in placebo-controlled trials for participants of all ages without performing subgroup analysis. While embracing the imperative to include children in research is an encouraging step towards providing the pediatric population with effective medical care and finally eradicating the therapeutic orphan, we must ensure that this research does not become overly permissive. 相似文献
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Fourteen southern and border states established a same-day presidentialprimary on 8 March 1988. This analysis shows that this SuperTuesday, in several senses, was less than super. The resultsturned out to be less satisfying than its Democratic founderspreferred but less upsetting than its critics anticipated. DespiteSuper Tuesday, Iowa and New Hampshire remained dominant in the1988 presidential primaries. Although voter turnout increasedslightly over 1984 and the results contributed mightily towardsettling the nomination in the Republican party, Super Tuesdayneither settled the Democratic nomination nor gave meaningfulmomentum to the more moderate Democratic candidates. 相似文献
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This article reports outcomes from a program of experimental research evaluating the risk principle in drug courts. Prior studies revealed that participants who were high risk and had (a) antisocial personality disorder or (b) a prior history of drug abuse treatment performed better in drug court when scheduled to attend biweekly judicial status hearings in court. In contrast, participants who were low risk performed equivalently regardless of the court hearings schedule. This study prospectively matches drug court clients to the optimal schedule of court hearings based on an assessment of their risk status and compares outcomes to clients randomly assigned to the standard hearings schedule. Results confirmed that participants who were high risk and matched to biweekly hearings had better during-treatment outcomes than participants assigned to status hearings as usual. These findings provide confirmation of the risk principle in drug courts and yield practical information for enhancing the efficacy and cost-efficiency of drug courts. 相似文献
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