Quantitative analysis of chlorpromazine by electron spin resonance (ESR) spectroscopy

A simple and sensitive method is described for quantitative analysis of chlorpromazine in blood, serum, urine and tissue homogenate. The chlorpromazine cation radical produced by adding perchloric acid and 2,3-dichloro-5,6-dicyano-p-benzoquinone to the sample can be detected by the ESR method at room temperature. The sensitivity limit is 10 ng, that is, 20 μl of the solution containing 0.5 μg chlorpromazine/ml. The time needed for the measurement is within 10 min. The chlorpromazine radical thus produced is very stable; for example, 95% of the radical was observed after 24 h. The advantage of this method is discussed by comparing with the ordinary spectrophotometry which requires the purification of the sample.     

Observations of high velocity bloodspatter on adjacent objects

In a recent homicide investigation, high velocity backspatter was observed on the sleeve cuff of the accused. These minute droplets were discovered only after microscopic examination and were limited in number. A study was initiated to determine if these were truly backspatter droplets or transferred blood produced from light contact with a bloody item. It was observed that the backspattered blood was primarily limited to contact or near contact shots. An exception was a shot into an already bloody surface. It was found that backspattered blood would deposit on the shooter's shirt sleeve irrespective of the weave pattern. Transferred blood was observed only on the fiber tops. This information was found to be useful in reconstruction of events in suicides as well as possible homicides.     

Does Federalism Weaken Democratic Representation in the United States?

The framers of the U.S. Constitution explicitly designed federalismto enhance representation. Because powers are divided amongmultiple governments, citizens are able to exert pressure onthe elected officials of various governments in an effort toachieve desired outcomes. If one government is not doing whatcitizens prefer, they can seek it from a different government.This assumes that individuals form opinions about the functionsperformed by different governments. Given the complexity offederalism, this may be an unrealistic assumption for many citizens.Original survey data uniquely suited to explore this questionsuggest that citizens do behave in a fashion consistent withthe federalist framework. Moreover, the actual change in theassignment of functional responsibilities across governmentsbehaves as if it responds to public opinion.