Development of a harmonised method for the profiling of amphetamines: III. Development of the gas chromatographic method

This study focused on gas chromatographic analysis of target compounds found in illicit amphetamine synthesised by the Leuckart reaction, reductive amination of benzyl methyl ketone, and the nitrostyrene route. The analytical method was investigated and optimised with respect to introduction of amphetamine samples into the gas chromatograph and separation and detection of the target substances. Sample introduction using split and splitless injection was tested at different injector temperatures, and their ability to transfer the target compounds to the GC column was evaluated using cold on column injection as a reference. Taking the results from both techniques into consideration a temperature of 250 degrees C was considered to be the best compromise. The most efficient separation was achieved with a DB-35MS capillary column (35% diphenyl 65% dimethyl silicone; 30 m x 0.25 mm, d(f) 0.25 microm) and an oven temperature program that started at 90 degrees C (1 min) and was increased by 8 degrees C/min to 300 degrees C (10 min). Reproducibility, repeatability, linearity, and limits of determination for the flame ionisation detector (FID), nitrogen phosphorous detector (NPD), and mass spectrometry (MS) in scan mode and selected ion monitoring (SIM) mode were evaluated. In addition, selectivity was studied applying FID and MS in both scan and SIM mode. It was found that reproducibility, repeatability, and limits of determination were similar for FID, NPD, and MS in scan mode. Moreover, the linearity was better when applying FID or NPD whereas the selectivity was better when utilising the MS. Finally, the introduction of target compounds to the GC column when applying injection volumes of 0.2 microl, 1 microl, 2 microl, and 4 microl with splitless injection respectively 1 microl with split injection (split ratio, 1:40) were compared. It was demonstrated that splitless injections of 1 microl, 2 microl, and 4 microl could be employed in the developed method, while split injection and splitless injections of 0.2 microl should be avoided.     

Development of a harmonized method for the profiling of amphetamines. I. Synthesis of standards and compilation of analytical data

Reference material was synthesised for 21 substances that are frequently present as synthetic impurities, i.e. by-products, in illicitly produced amphetamine. Each of these substances is a typical by-product for at least one of the three approaches most often used to synthesise amphetamine, namely, the Leuckart, the reductive amination of benzyl methyl ketone, and the nitrostyrene routes. A large body of data on the substances was recorded, including the following: mass spectra, ultraviolet spectra, Fourier transform infrared spectra, infrared spectra in gas phase, and 1H NMR and 13C NMR spectra.     

Development of a harmonized method for the profiling of amphetamines. II. Stability of impurities in organic solvents

The present study focused on the stability of 22 amphetamine impurities dissolved in six organic solvents: isooctane, toluene, ethanol, dichloromethane, ethyl acetate, and diethyl ether. The aim was to find the most inert, and thereby most suitable, solvent for amphetamine profiling. Mixtures of the impurities were prepared in the different solvents, and changes in the concentrations of the individual compounds over-time were monitored by gas chromatographic analysis after 0, 4, 12, 24, 48, and 96 h. Isooctane and toluene provided the most inert conditions, although, a few of the impurities were insufficiently stable in these two solvents. The present experiments were performed as a part of the development of a harmonized method for profiling of amphetamine. The results can be used to support the choice of organic solvents for sample preparation. They also provide information about the stability of the impurities that are found in profiles of illicit amphetamine. This is essential due to the fact, that unstable compounds can have a negative influence on the comparison of profiles.     

Group therapy for women sexually abused as children: mental health before and after group therapy

Forty-five female outpatients sexually abused in childhood were offered a 2-year phase-divided group therapy. Before and after treatment and at 12 months follow-up, they answered questionnaires designed to elicit responses concerning psychological symptoms (Symptom Checklist; SCL-90) and sense of coherence (SOC). Symptoms for posttraumatic stress disorder (PTSD) were assessed before and after treatment. Inpatient days and sick listing days were assessed during 2 years before and 2 years after treatment. The psychological and PTSD symptoms were significantly reduced after treatment, and the SOC was increased as well. Inpatient days were decreased, and sick listing days increased but not significantly. Compared to a similar short-term focused therapy group and a waiting-list group there were no significant differences between the groups. Trauma-focused group therapy for women who were sexually abused in childhood seems to have promising effects on mental health, both concerning long-term and short-term approaches.     

Democracy and Security in the EU’s Eastern Neighborhood? Assessing the ENP in Georgia,Moldova, and Ukraine

This article explores the European Union’s (EU) democratic and security objectives in the European Neighborhood Policy (ENP) toward three post-Soviet states: Georgia, Moldova, and Ukraine. By discussing the ENP’s objectives, this study concludes the following: first, despite long-term ENP democracy promotion, there have been very limited democratic developments in the partner states between 2005 and 2014; second, security challenges remain in partner states in the breakaway regions in Transnistria in Moldova, Abkhazia and South Ossetia in Georgia, and Crimea, Donetsk, and Luhansk in Ukraine. Therefore, EU’s Kantian view of security through democracy has failed, and its ambition to create a ring of Eastern friends has not led to improved relations in the Eastern neighborhood. On the contrary, the EU’s push eastward has instead intensified insecurity in its partner states due to limited democratization.     

Justice Judgments of Physical Abuse and Theft: The Importance of Outcome and Procedure

The perceived justice of a situation is frequently a function of both outcome and procedure, but the importance of each may vary when making justice judgments. This study investigated the impact of type and severity of offence, social relationship and status on the perceived importance of the outcome and procedure for justice judgments. The outcome was considered more important than the procedure for judgments of both theft and physical abuse, regardless of offence severity, status of the offender and the victim–perpetrator social relationship. Both outcome and procedure were viewed as more important for judgments of physical abuse than theft. Data obtained for exploratory purposes yielded no correlation between ratings of justice and importance, indicating that the two are not aspects of the same construct. Integrations with work within criminology are discussed.     

Civil society actors in peace negotiations in Central America

Civil society actors are assumed to play an important part in post-conflict peacebuilding; therefore, the international community pushes for civil society participation already during peace negotiations. However, the actual connection between civil society’s participation in those negotiations and its role in implementation processes remains unclear. Taking the Central American peace processes of the late 1980s and early 90s as a case study, this article compares civil society participation in peace negotiations and provisions for civil society involvement for the implementation phase, with the actual role that the civil society played in the implementation processes in Nicaragua, Guatemala and El Salvador. The article questions the importance of including civil society actors in the negotiation process since the level of civil society inclusion in, activism during and influence on the negotiation process in the three cases did not result in a stronger role for civil society organizations in the implementation process. The article concludes with an analysis of how these findings modify the current understanding of the role of civil society in peace processes and proposes a different focus for future research.     

A 24-Year Follow-up Study on Recidivism in Male Mentally Disordered Sexual Offenders With and Without Psychotic Disorders

There is a lack of knowledge on mentally disordered sex offenders (MDSOs) targeting adult victims, especially regarding recidivism patterns and the specific subgroup with psychiatric disorders. This paper presents index offense data, clinical data, and recidivism patterns over up to 24 years in a cohort of 146 MDSOs, with and without psychotic disorders, sentenced in Sweden between 1993 and 1997. At the time of the offense, all offenders were affected by clinical, developmental, and criminal history factors. MDSOs with psychotic disorders only marginally differed from those without, the former being less likely to have been institutionalized during childhood, intoxicated during the index offense, or diagnosed with a personality disorder, substance use disorder, or paraphilic disorder. In the cohort, 3.4% of the MDSOs were reconvicted for a new sex offense over 2 years, 9.6% over 5 years, 13.0% over 10 years, and 17.1% over the entire follow-up period of 24 years. In MDSOs with psychotic disorders, no subjects were reconvicted during the first 2 years, while 2.6% were reconvicted over 5 years, 5.3% over 10 years, and 7.9% over 24 years. Recidivism rates for violent and general reoffenses were 39.0% and 37.7%, respectively, for the cohort of MDSOs, and subjects with psychotic disorders reoffended significantly later in general offenses. In conclusion, MDSOs with psychotic disorders showed the same recidivism pattern as MDSOs without psychotic disorders. Furthermore, recidivism research may preferably focus on follow-up periods of 5–10 years since most offenders appear to recidivate within this timeframe.