Regionalist governance in the new political economy of development: 'Relaunching' the Mercosur

The splintering of the Mercosur following the Brazilian devaluation in early 1999 has given way to an important re-crafting of the regional vision and a significant expansion of the scope of the regional project. This article contends that these trends can best be understood as coalescing into a new (and nascent) form of regionalist governance in the Southern Cone, in which the Mercosur is reconfigured as a vehicle for a new set of developmentalist and strategic objectives. This emerging form of regionalist governance is both causative and indicative of a new political economy both of the subregion and of the wider region of the Americas, and reflective of the crystallisation of a new political economy of development.     

Accidental death from hydromorphone ingestion

Abstract: A 15‐year‐old male orally consumed an unknown but fatal amount of sustained release hydromorphone. He was naïve to opioid use. No other drugs or alcohol were involved. The cause of death was acute aspiration‐related bronchopneumonia, secondary to hydromorphone ingestion; the manner of death was accidental. Hydromorphone and hydromorphone‐3‐glucuronide were quantified in postmortem fluids by tandem liquid chromatography–mass spectrometry. The hydromorphone concentrations in the peripheral blood, urine, and vitreous humor were 57, 4460, and 31 ng/mL, respectively. The hydromorphone‐3‐glucuronide concentrations in the corresponding three fluids were 459, 36,400, and 40 ng/mL. Hydromorphone‐3‐glucuronide accumulation probably did not contribute significantly to the opiate toxicity. The proposed minimum lethal hydromorphone blood concentration in the nontolerant user is in the vicinity of 60 ng/mL.     

Screening tablets for DOB using surface-enhanced Raman spectroscopy

2,5,-Dimethoxy-4-bromoamphetamine (DOB) is of particular interest among the various "ecstasy" variants because there is an unusually long delay between consumption and effect, which dramatically increases the danger of accidental overdose in users. Screening for DOB in tablets is problematic because it is pharmacologically active at 0.2-3 mg, which is c. 50 times less than 3,4-methylenedioxy-N-methylamphetamine (MDMA) and makes it more difficult to detect in seized tablets using conventional spot tests. The normal Raman spectra of seized DOB tablets are dominated by the bands of the excipient with no evidence of the drug component. Here we report the first use of on-tablet surface-enhanced Raman spectroscopy (SERS) to enhance the signal from a low concentration drug. Raman studies (785-nm excitation) were carried on series of model DOB/lactose tablets (total mass c. 400 mg) containing between 1 mg and 15 microg of DOB and on seized DOB tablets. To generate surface-enhanced spectra, 5 microL of centrifuged silver colloid was dispensed onto the upper surface of the tablets, followed by 5 microL of 1.0 mol/dm(3) NaCl. The probe laser was directed onto the treated area and spectra accumulated for c. 20 sec (10 sec x 2). It was found that the enhancement of the DOB component in the model tablets containing 1 mg DOB/tablet and in the seized tablets tested was so large that their spectra were completely dominated by the vibrational bands of DOB with little or no contribution from the unenhanced lactose excipient. Indeed, the most intense DOB band was visible even in tablets containing just 15 microg of the drug. On-tablet surface-enhanced Raman spectroscopy is a simple method to distinguish between low dose DOB tablets and those with no active constituent. The fact that unique spectra are obtained allows identification of the drug while the lack of sample preparation and short signal accumulation times mean that the entire test can be carried out in <1 min.     

Reconsidering the relationship between alcohol and lethal violence

Prior event-based research regarding the relationship between alcohol and violence suffers from important limitations, including the absence of a comparison group, an inappropriate comparison group, or a comparison group that could be considered appropriate but does not control for potential confounders. To overcome such limitations, we use a matched pair design. Drawing on interviews with men imprisoned for an aggravated assault or homicide committed in response to a conflict with another man, we examine matched pairs of violent and nonviolent conflicts nested within respondents. The results suggest that guns mediate the relationship between alcohol and lethal male-male violence.     

The patent lottery

A recent study by Boston academic economists James Bessen andMichael Muerer has argued that many patents are simply not worthhaving. Their case is based on the analysis of a large bodyof data. As James Bessen says, in a comment posted in responseto criticism on the IPKat weblog,

"We derived our estimatesof patent rents after reviewing 16 different papers publishedover 25 years, involving 17 different authors and several differentmethodologies.     

Emergency Management Research and Practice in Public Administration: Emergence,Evolution, Expansion,and Future Directions

In 1984, the Federal Emergency Management Agency (FEMA) and the National Association of Schools of Public Affairs and Administration (NASPAA) collaborated to foster a community of scholars focused on research and professional practice in emergency management. The intent was to build a community of researchers and professional practitioners who would support improved performance for an increasingly challenging set of problems confronting emergency managers at all levels of jurisdiction. The financial investment was small, but the NASPAA/FEMA initiative led to the evolution of a community of scholars engaged in emergency management research and professional practice. The authors review changes in FEMA since the 1984 workshop and the impact of the NASPAA/FEMA fellows on research and practice in emergency management, placing this initiative in the wider context of public administration.     

A qualitative study using a systemic perspective exploring the remediation of abusive interactions in intimate heterosexual couples

Very little attention has been paid to both partners beliefs about why violence in their previously abusive relationship has stopped or significantly reduced despite well-documented details in the research literature outlining the characteristics of both victims and perpetrators. This study aimed to provide some understanding of how each partner believed that the violence has ended. However their answers often were not definitive; instead, they uncovered the complexities in their relationship and their struggle to overcome the uncertainty they have to achieve and maintain successful remediation. The article is based on a qualitative Interpretative Phenomenological Analysis (IPA) study that explored the nature of the relationship between six heterosexual couples before and after a therapeutic intervention for the men perpetrators, which followed the Duluth Model. The study included how they both understood the violence and how they maintained nonviolence in their relationship. The men were notably still in the process of reprocessing their understanding of why they were violent and they needed to further understand their reactions to maintain their nonviolence. The IPA themes provided some understanding of how the participants thought they had a better understanding of the factors that had maintained their relationship since the termination of the intervention. The themes, generated from the interviews provided by the perpetrators and their victims, are explored and some explanations for the successful continuation of their relationship following treatment are suggested. Implications for widening the treatment options for men perpetrators are suggested in addition to providing treatment options for couples who wish to remain within their relationships and need help to identify unhelpful and dangerous patterns of interaction.     

Perpetrator programmes for partner violence: A rejoinder to Respect

Purpose. To reply to the comments made by Debbonaire and Todd (2012) in relation to our critique of Respect's Position Statement. Method. We examined their reply in relation to our original article and to the wider research literature. Results. We show that Debbonaire and Todd's reply is largely a series of assertions, for which little or no supporting evidence is offered. Their argument is first that we are misplaced in criticizing their Position Statement, and second that the main points of the statement are defendable. We indicate why our criticisms of the statement still stand. Conclusions. We argue that Respect have not countered our overall criticism of their position that intimate partner violence (IPV) can only be addressed as a gendered issue, that is as a consequence of patriarchal values enacted at the individual level. Instead we advocate a gender‐inclusive approach applying a knowledge base derived from robust empirical research on IPV and more widely from research on human aggression.     

A psychometric evaluation of the Defence Style Questionnaire-40 in a UK forensic patient population

Psychological defence mechanisms have been considered important personality processes in the onset, maintenance and recovery of mental disorders. More recently, their application to understanding presenting problems and as potential outcome indicators for forensic patients has been recommended. However, to date there have been no investigations into the reliability and factor structure of defence mechanism assessments for this population. The current study investigated the factor structure, internal consistency and test-retest reliability of the Defence Style Questionnaire-40 (DSQ) for 160 adult male UK forensic patients. The three-factor model of defences proposed by the DSQ-40 developers was not confirmed in the study sample. Reliability indices of the three factors indicated that the Immature factor was the most ‘acceptable’ in terms of internal consistency. Test-retest reliability coefficients ranged from .70 to .91. A revised three-factor structure that closely corresponds to the original validation study is recommended following an exploratory factor analysis. The findings are compared with previous reliability and factor analytic evaluations of the DSQ-40, and recommendations for its use with forensic patients are discussed.     

Integrating Growth Variability of the Ilium,Fifth Lumbar Vertebra,and Clavicle with Multivariate Adaptive Regression Splines Models for Subadult Age Estimation

Subadult age estimation should rely on sampling and statistical protocols capturing development variability for more accurate age estimates. In this perspective, measurements were taken on the fifth lumbar vertebrae and/or clavicles of 534 French males and females aged 0–19 years and the ilia of 244 males and females aged 0–12 years. These variables were fitted in nonparametric multivariate adaptive regression splines (MARS) models with 95% prediction intervals (PIs) of age. The models were tested on two independent samples from Marseille and the Luis Lopes reference collection from Lisbon. Models using ilium width and module, maximum clavicle length, and lateral vertebral body heights were more than 92% accurate. Precision was lower for postpubertal individuals. Integrating punctual nonlinearities of the relationship between age and the variables and dynamic prediction intervals incorporated the normal increase in interindividual growth variability (heteroscedasticity of variance) with age for more biologically accurate predictions.