Does Targeted,Disease‐Specific Public Research Funding Influence Pharmaceutical Innovation?

Public funding for biomedical research is often justified as a means to encourage development of more (and better) treatments for disease. However, few studies have investigated the relationship between these expenditures and downstream pharmaceutical innovation. In particular, although recent analyses have shown a clear contribution of federally funded research to drug development, there exists little evidence to suggest that increasing targeted public research funding for any specific disease will result in increased development of drugs to treat that disease. This paper evaluates the impact of changes in the allocation of U. S. National Institutes of Health (NIH) extramural research grant funding across diseases on the number of drugs entering clinical testing to treat those diseases, using new longitudinal data on NIH extramural research grants awarded by disease for years 1975 through 2006. Results from a variety of distributed lag models indicate that a sustained 10 percent increase in targeted, disease-specific NIH funding yields approximately a 4. 5 percent increase in the number of related drugs entering clinical testing (phase I trials) after a lag of up to 12 years, reflecting the continuing influence of NIH funding on discovery and testing of new molecular entities. In contrast, we do not see evidence that increases in NIH extramural grant funding for research focused on specific diseases will increase the number of related treatments investigated in the more expensive, late-stage (phase III) trials.     

A Four‐Stage Method of Age at Death Estimation for Use in the Subadult Rib Cortex*,†

Abstract: Age estimation in the subadult skeleton can be rather precise when the epiphyses and dentition are present, but incomplete or commingled remains still present a challenge. Histomorphometric age‐at‐death estimation methods developed for use on adults are based on the age‐associated accumulation of osteons. In the growing skeleton, there is a poor correlation between osteon numbers and age until the latter half of the second decade. As a result, there has been no histological aging method for use in subadults. The analysis of the rib cortex of 72 subadults ranging in age from 2 to 21 years has identified a series of developmental changes in the bone microstructure that can be used to estimate age. This qualitative method utilizes the systematic changes in rib cortical morphology to classify ribs into one of four age phases. This method can be applied to immature skeletons in forensic, archaeological, and paleontological contexts.     

The Effects of Rehabilitative Voir Dire on Juror Bias and Decision Making

During voir dire, judges frequently attempt to “rehabilitate” venirepersons who express an inability to be impartial. Venirepersons who agree to ignore their biases and base their verdict on the evidence and the law are eligible for jury service. In Experiment 1, biased and unbiased mock jurors participated in either a standard or rehabilitative voir dire conducted by a judge and watched a trial video. Rehabilitation influenced insanity defense attitudes and perceptions of the defendant’s mental state, and decreased scaled guilt judgments compared to standard questioning. Although rehabilitation is intended to correct for partiality among biased jurors, rehabilitation similarly influenced biased and unbiased jurors. Experiment 2 found that watching rehabilitation did not influence jurors’ perceptions of the judge’s personal beliefs about the case.     

Wellbeing,occupational justice and police practice: an ‘affirming environment’?

This paper examines wellbeing and occupational justice within the police profession. The research presented is based on a preliminary study utilising a qualitative methodology in which 14 in-depth interviews were conducted with rank and file police officers in one state of Australia. The data-set reveals that there are many positive aspects to being a police officer, contrary to the ‘dysfunction’ research that exists concerning the police in which corruption and poor performance prevails. The data analysis supports the notion that the practice of the police can be understood through a framework of wellbeing, occupational justice, and positive psychology. Whilst the research yields strong positive aspects in the work police officers engage in, as well as in their working environment, there are challenges within the profession, namely dealing with traumatic events that can hinder wellbeing and occupational justice. This study offers evidence to reflect on current policies and practices in terms of police recruitment, education and training. The study also offers evidence for improving staff retention by building on the principles of wellbeing and occupational justice within police practice.     

An evaluation of a group treatment approach for children who have witnessed wife abuse

The present study evaluated a time-limited group treatment program developed by Jaffe et al.(1986) for child witnesses of wife abuse. The sample of children between the ages of 8–13 years, in both the treatment and control groups, was referred by agencies in the community. The evaluation based on the Child Witness to Violence Questionnaire, measured three variables: attitudes and responses to anger, knowledge of support and safety skills, and sense of responsibility for the parents and for the violence. An analysis of covariance of the pretreatment/posttreatment data showed significant differences on the first and third variables: attitudes and responses to anger, and sense of responsibility for the parents and violence measured. The second variable, safety and support skills, showed no significant difference between groups. Consideration was given to additional findings, limitations of the study, and recommendations for program change.