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111.
Montesino M Salas A Crespillo M Albarrán C Alonso A Alvarez-Iglesias V Cano JA Carvalho M Corach D Cruz C Di Lonardo A Espinheira R Farfán MJ Filippini S García-Hirschfeld J Hernández A Lima G López-Cubría CM López-Soto M Pagano S Paredes M Pinheiro MF Rodríguez-Monge AM Sala A Sóñora S Sumita DR Vide MC Whittle MR Zurita A Prieto L 《Forensic science international》2007,168(1):42-56
The mitochondrial DNA (mtDNA) working group of the GEP-ISFG (Spanish and Portuguese Group of the International Society for Forensic Genetics) carried out an inter-laboratory exercise consisting of the analysis of mtDNA sequencing patterns in mixed stains (saliva/semen and blood/semen). Mixtures were prepared with saliva or blood from a female donor and three different semen dilutions (pure, 1:10 and 1:20) in order to simulate forensic casework. All labs extracted the DNA by preferential lysis and amplified and sequenced the first mtDNA hypervariable region (HVS-I). Autosomal and Y-STR markers were also analysed in order to compare nuclear and mitochondrial results from the same DNA extracts. A mixed stain prepared using semen from a vasectomized individual was also analysed. The results were reasonably consistent among labs for the first fractions but not for the second ones, for which some laboratories reported contamination problems. In the first fractions, both the female and male haplotypes were generally detected in those samples prepared with undiluted semen. In contrast, most of the mixtures prepared with diluted semen only yielded the female haplotype, suggesting that the mtDNA copy number per cell is smaller in semen than in saliva or blood. Although the detection level of the male component decreased in accordance with the degree of semen dilution, it was found that the loss of signal was not consistently uniform throughout each electropherogram. Moreover, differences between mixtures prepared from different donors and different body fluids were also observed. We conclude that the particular characteristics of each mixed stain can deeply influence the interpretation of the mtDNA evidence in forensic mixtures (leading in some cases to false exclusions). In this sense, the implementation of preliminary tests with the aim of identifying the fluids involved in the mixture is an essential tool. In addition, in order to prevent incorrect conclusions in the interpretation of electropherograms we strongly recommend: (i) the use of additional sequencing primers to confirm the sequencing results and (ii) interpreting the results to the light of the phylogenetic perspective. 相似文献
112.
BackgroundA seasonal variation in violence and suicidal behaviour has been reported in several studies with partially congruent results. Most of forensic psychiatric patients have a history of severe violent behaviour that often continues in spite of regular treatment. In the forensic psychiatric hospital environment aggressive and suicidal acts are often sudden and unpredictable. For reasons of safety, rapid and intensive coercive measures, such as seclusion and restraint, are necessary in the treatment of such patients.ObjectiveTo examine whether these involuntary seclusions have a seasonal pattern, possibly similar than the reported seasonal variation in violence and suicidal behaviour. By investigating the possibility of a seasonal variation of seclusion incidents from violent and suicidal acts, it may become possible to improve the management of forensic psychiatric patients.MethodsThe hospital files of all secluded patients at Niuvanniemi Hospital from 1 January 1996 to 31 December 2002 were examined. In total, 385 patients (324 male and 61 female) were identified as being secluded at least once in 1930 different incidents (1476 from male and 454 from female patients). Seasonal decomposition and linear regression with dummy month variables were used to examine the possibility of annual variations for seclusions.ResultsThe seasonal variation of involuntary seclusion incidents was statistically significant. According to the linear regression model, most of the seclusion incidents, affecting many different patients, began in July and August, and were concentrated throughout the fall until November. The sum of all seclusion days was lowest in January and highest between July and November (difference + 31% to + 37%).ConclusionsThese findings are mainly in agreement with results from other studies on seasonal variation and violent behaviour. The allocation of staff for late summer and fall might enhance the management of forensic psychiatric patients, thus leading to possible decreases in seclusion incidents. The factors affecting violent, aggressive and suicidal behaviours are complex and more investigation is needed to understand, identify, intervene and effectively reduce such behaviours. 相似文献
113.
Marie-Dominique Piercecchi-Marti Andre Maues De Paula Gilles Gavaudan Christophe Bartoli Anne-Laure Pelissier-Alicot Georges Leonetti Jean-François Pellissier 《Forensic science international》2010,194(1-3):e1-e3
Aggressive or paradoxical behaviour may reflect an organic dementia. The most frequent is Alzheimer's disease, which results from an abnormal structural conformation of tubulin-associated protein (tau) and beta-amyloid protein that, respectively, aggregate in certain neurons as intracellular neurofibrillary tangles (NFTs) and in the extracellular environment as senile plaques.These lesions progress in the brain tissue according to the stages described by Braak and Braak. Staging of neurofibrillary pathology has proven anatomical and clinical correlation, which can be used in a medico-legal procedure. We report two cases demonstrating discrepancies between anatomical and clinical features, which should encourage medical expert to prudence when interpreting neuropathological reports. 相似文献
114.
Paula M. Kautt 《American Journal of Criminal Justice》2009,34(3-4):253-273
Grid based sentencing guidelines, composed of offense seriousness and offender criminal history axis, have become a staple of US sentencing in recent decades. As such, extensive research explores whether they reduce extralegal sentence disparity. However, to date, no study has examined whether extralegal disparity is present in how either axis of guideline sentencing are constructed. Using federal sentencing commission data along with both single and multi-level analyses, this research explores the legal and extralegal factors that predict one of these key grid axes: the offense seriousness score. The results call into question not only some assumptions underlying guideline sentencing but also recent analytical strategies for assessing sentencing outcomes in guideline systems. 相似文献
115.
Paula Núñez Martínez Sofía T. Menéndez María de los Ángeles Villaronga Douglas H. Ubelaker Juana M. García-Pedrero Sara C. Zapico 《Science & justice》2019,59(4):418-424
Recent developments on postmortem interval estimation (PMI) take an advantage of the autolysis process, pointing out to the analysis of the expression of apoptosis and autophagy genes towards this purpose. Oxidative stress plays a role in this signaling as a regulatory mechanism and/or as a consequence of cell death. Additionally, melatonin has been implicated on apoptosis and autophagy signaling, making melatonin a suitable target for PMI determination. The aim of this study was to investigate the early PMI through the analysis of the expression of autophagy genes as well as oxidative stress and melatonin receptor. Our results demonstrated a rapidly increased on the expression of autophagy genes according to the expected sequence of events, then a marked decrease in this expression, matched with the switch to the apoptosis signaling. These results revealed potential candidates to analyze the PMI in the first hours of death, helping to estimate the time-since-death. 相似文献
116.
Rafael Prieto Curiel Sofía Collignon Delmar Steven Richard Bishop 《Journal of Quantitative Criminology》2018,34(3):775-803
Objectives
Generally speaking, crime is, fortunately, a rare event. As far as modelling is concerned, this sparsity of data means that traditional measures to quantify concentration are not appropriate when applied to crime suffered by a population. Our objective is to develop a new technique to measure the concentration of crime which takes into account its low frequency of occurrence and its high degree of concentration in such a way that this measure is comparable over time and over different populations.Methods
This article derives an estimate of the distribution of crime suffered by a population based on a mixture model and then evaluates a new and standardised measurement of the concentration of the rates of suffering a crime based on that distribution.Results
The new measure is successfully applied to the incidence of robbery of a person in Mexico and is able to correctly quantify the concentration crime in such a way that is comparable between different regions and can be tracked over different time periods.Conclusions
The risk of suffering a crime is not uniformly distributed across a population. There are certain groups which are statistically immune to suffering crime but there are also groups which suffer chronic victimisation. This measure improves our understanding of how patterns of crime can be quantified allowing us to determine if a prevention policy results in a crime reduction rather than target displacement. The method may have applications beyond crime science.117.
Paula Mulinari 《Nora, Nordic Journal of Women's Studies》2018,26(2):84-98
Austerity policies across European countries have encountered diverse forms of public protest and resistance. In Sweden, we have seen the emergence of a number of networks and organizations which take care workers’ professional identity as their point of departure. These networks and organizations stress the impossibility of being professional care workers in slimmed-down, neoliberal organizations. Parallel to this, and sometimes embedded into one another, female-dominated professions (e.g. social workers, nurses, doctors, and teachers) have been engaged in opposing restrictive refugee policies. This article analyses how care workers in an emergency room in Malmö mobilized against a visit by Jimmie Åkesson, leader of the right-wing, xenophobic Sweden Democrats. The article explores how workers used a gendered discourse of care and professionalism to argue that their actions were consistent with both organizational culture and their professional ethics. The article shows how, by defending their professional role of providing quality care to all in need, workers challenge both austerity and racist policies, which both impose restrictions on who has the right to care. Theoretically, the article explores how the politicization of care creates spaces of resistance, to critique both austerity policies and exclusionary understandings of national belonging. The study stresses the importance of identifying emerging forms of collective resistance among care workers at the intersection of the struggles against austerity and right-wing xenophobic parties. 相似文献
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