An hepatic metabolic profile in sudden infant death (SIDS)

Levels of 18 enzymes and metabolites were measured in liver obtained at autopsy from 41 infants, 28 of whom were found unexpectedly dead at home. Four infants had meningitis, 11 had pathologic findings not clearly sufficient to explain death (SUD), and 13 were considered totally unexplained pathologically (SIDS). The possible contributions of postmortem interval, age and diet to the results are reviewed. No characteristic metabolic profile was recognized amongst SUD and SIDS groups. It is speculated that the amount of glycogen found in liver may provide insight into premortal events and reflect the rapidity of the death mechanism. Five individuals (20%) were suspected of having major metabolic abnormality including glycogenosis (1), urea cycle defect (1), and possibly abnormal levels of carnitine palmityl transferase (3).     

Research utilization in policymaking: A tale of two series (of social experiments)

This paper is an exploratory attempt to view the role that social experiments in general, and the income maintenance experiments and work/welfare demonstrations in particular, have played in the policy process through the lens provided by the knowledge utilization literature. In addition to suggesting that the decision to conduct a social experiment is rarely, if ever, made according to an essentially rational paradigm, this framework helps highlight the range of uses to which findings from social experiments can be put and the circumstances under which various types of uses are more or less likely. Specifically, the knowledge utilization literature suggests that rather than having the dramatic, decisive effects on policy choices that their promoters have often envisioned, social experiments are more likely to affect policy in a variety of subtle ways.     

USING LINEAR TREND MODELS TO ANALYZE POLICY IMPACT

Policy researchers have become increasingly familiar with a number of improved techniques for analyzing data obtained from interrupted time-series designs for evaluating public programs and policies. In this paper we contribute to this trend by presenting two groups of data analysis techniques which are not currently widely used by policy researchers, but are likely to be valuable adjuncts to traditional regression techniques for analyzing data obtained from interrupted time-series designs. First, aids for model specification are presented that enable the analyst to define an appropriate linear trend model—often one which will reduce the degree of multicollinearity and, therefore, produce more precise estimates of the impacts of a public program or policy. Next we consider approaches for point estimation and joint (simultaneous) interval estimation of a policy intervention's total effect at various points in time.     

Cognitive Maelstroms,Nested Negotiation Networks,and Cascading Decision Effects: Modeling and Teaching Negotiation Complexity with Systemic Multiconstituency Exercises

Negotiation practitioners today struggle to manage complex political, economic, and cultural disputes that often involve an array of intertwined issues, parties, process choices, and consequences – both intended and unintended. To prepare next‐generation negotiators for these multifaceted challenges, negotiation instructors must keep pace with the rapidly evolving complexity of today's world. In this article, we introduce systemic multiconstituency exercises (SMCEs), a new educational tool for capturing this emerging reality and helping to close the experiential learning gap between the simulated and the non‐simulated environment. We discuss our pedagogical rationale for developing The Transition, a seventy‐two‐party SMCE inspired by the complex conflicts in Afghanistan and Central Asia and then describe our experiences conducting multiple iterations of this simulation at Harvard University. We argue that SMCEs, in which stakeholders are embedded in clusters of overlapping networks, differ from conventional multiparty exercises because of their immersive character, emergent properties, and dynamic architecture. This design allows for the creation of crucial negotiation complexity challenges within a simulated exercise context, most importantly what we call “cognitive maelstroms,” nested negotiation networks, and cascading decision effects. Because of these features, SMCEs are uniquely suited for training participants in the art of network thinking in complex negotiations. Properly designed and executed, systemic multiconstituency exercises are next‐generation teaching, training, and research platforms that carefully integrate negotiation, leadership, and decision‐making challenges.     

The dissemination and utilization of welfare‐to‐work experiments in state policymaking

Abstract This paper reports the results of a telephone survey of state‐level officials as to the influence of evaluations of three state welfare innovations: California's GAIN, New York's CAP, and Florida's Project Independence. The three experiments were known to those interviewed, yet they did not have dramatic, decisive effects on policymaking. However, GAIN and CAP appear to have influenced policymaking in less dramatic and more subtle respects. Much more important than empirical findings about the effects of tested programs was information about how these programs actually operated in the field along with evidence that the policies tested in welfare‐to‐work experiments were logically consistent (that is, there was no obvious reason to think that they would be unsuccessful), could clear federal waivers, and would not encounter major political resistance. © 2000 by the Association for Public Policy Analysis and Management.     

Legal Issues and Human Rights Dimensions of the Israeli Settlements Issue: Victims and Spoilers

The presenters on this panel discussed several important additional requirements for the successful implementation of a two-state solution that involves significant relocation of settlers. These requirements include balancing rights among different groups, minimizing the impact of "spoilers," and providing political compensation to settlers. Presenters also highlighted the relevance of elements of classic negotiation theory to this issue, including thinking creatively about substance and paying appropriate attention to process.     

Network Structures: Working Differently and Changing Expectations

There is a growing need for innovative methods of dealing with complex, social problems. New types of collaborative efforts have emerged as a result of the inability of more traditional bureaucratic hierarchical arrangements such as departmental programs to resolve these problems. Network structures are one such arrangement that is at the forefront of this movement. Although collaboration through network structures establishes an innovative response to dealing with social issues, there remains an expectation that outcomes and processes are based on traditional ways of working. It is necessary for practitioners and policy makers alike to begin to understand the realities of what can be expected from network structures in order to maximize the benefits of these unique mechanisms.     

COMMUNITY COLLABORATIONS:

Many communities are now involved in collaborations in order to solve problems which no one group or organization can deal with by themselves. They find they must organize in a unique way that allows them to try to solve these problems on equal terms with the public, non-profit and private sectors. These unique collaborations are referred to in this article as network structures. Network structures require the use of different management styles and policy instruments than are used in more typical bureaucratic efforts. This article is based on a study of four community groups in the Los Angeles area which organized in such a way to try to improve conditions of families and children. Each of these collaborations highlights the impact of network structures on the ability to sustain effective collaborative efforts. In addition they point to new roles and changing relationships among government at all levels and those participants outside the government. They also highlight what participants, both inside and outside the public sector, will need to understand about how to organize and mange in these unique settings.