Simultaneous analyses of cocaine, cocaethylene, and their possible metabolic and pyrolytic products

A method was developed for simultaneously analyzing cocaine (COC), benzoylecgonine (BZE), norbenzoylecgonine (BNE), norcocaine (NCOC), ecgonine (ECG), ecgonine methyl ester (EME), m-hydroxybenzoylecgonine (HBZE), anhydroecgonine methyl ester (AEME), cocaethylene (CE), norcocaethylene (NCE), and ecgonine ethyl ester (EEE) in blood, urine, and muscle. Available deuterated analogs of these analytes were used as internal standards. Proteins from blood and muscle homogenate were precipitated with cold acetonitrile. After the removal of acetonitrile by evaporation, the supernatants and urine were subjected to solid-phase extraction. The eluted analytes were converted to their hydrochloride salts and derivatized with pentafluoropropionic anhydride and 2,2,3,3,3-pentafluoro-1-propanol. The derivatized products were analyzed by a gas chromatograph (GC)/mass spectrometer by selected ion monitoring. The limit of detection (LOD) for COC, BZE, NCOC, EME, CE, NCE, and EEE was 2ng/ml, while the LODs for BNE, ECG, HBZE, and AEME were 25, 640, 50, and 13 ng/ml, respectively. This method was successfully applied in analyzing 13 case samples from aviation accident pilot fatalities and motor vehicle operators. AEME concentrations found in the 13 samples were consistent with those produced solely by the GC inlet pyrolysis of COC controls in blood. Anhydroecgonine cannot be used as a marker for the abuse of COC by smoking because it is also pyrolytically produced from COC metabolites on the GC inlet. The developed method can be effectively adopted for analyzing COC and related compounds in urine, blood, and muscle by a single extraction with increased sensitivity through formation of hydrochloride salts and using a one-step derivatization.     

Party composition in the American states: Clarifying concepts and explaining changes in partisanship since the 1950s

Students of state politics have long been interested in the partisanship and the degree of interparty competition in the American states. This has led to numerous attempts to quantify state-level partisanship and competition, the most significant by Ranney (1965). Interestingly, however, scholars have never specified clearly the relationship between these two concepts as measured by the Ranney index. This research attempts to do just that and reveals that the two are different measures which are related systematically. More important, understanding changes in a state's partisanship is determined to be crucial to understanding changes in its level of two-party competition. As such, in order to explain changes in partisanship and competition across the American states from the 1950s to the 1970s, we focus on accounting for changes in partisanship. To this end, changes in aggregate demographic variables account very well for states' movement along the Ranney index over the last 3 decades.The names of the authors appear in alphabetical order and imply that this paper is in every way a collaborative enterprise.     

Can ministries of health support primary health care? Some suggestions for structural reorganization and planning

Patrick Vaughan is Reader in health care epidemiology, Gill Walt is Lecturer in health policy and Anne Mills is Lecturer in health economics, at the Evaluation and Planning Centre for Health Care, London School of Hygiene and Tropical Medicine, Gower Street, London WC1, United Kingdom. A previous version of this paper was prepared for the Commonwealth Secretariat, London, for the Conference of Commonwealth Health Ministers held in Ottawa, Canada, in October 1983.     

Regulators and Redskins

We examine the correlation between federal government activity and performance of the capital’s National Football League team, the Washington Redskins. We find a positive, non-spurious, and robust correlation between the Redskins’ winning percentage and bureaucratic output, measured by pages published in the Federal Register. Because the Redskins’ performance is prototypically exogenous, we give this result a causal interpretation and provide a plausible, causal mechanism: bureaucrats must make “logrolling” deals to expand their regulatory power, and a winning football team offers a shared source of optimism to lubricate such negotiations. We do not find the same correlation when examining congressional activity.     

Deliberation in large juries with diverse preferences

This paper considers a game in which imperfectly informed jurors who differ in their thresholds of reasonable doubt must decide whether to convict or acquit a defendant. Jurors deliberate prior to voting on the fate of the defendant, and the defendant is convicted only if all jurors vote to convict. Although it has been established that full information revelation is impossible when jurors have sufficiently heterogeneous preferences, this paper demonstrates that if each juror shares preferences with a small fraction of the other jurors, it is possible to obtain enough information revelation so that the correct decision is made with probability arbitrarily close to one in large juries.     

Policy and Organizational Change in the Federal Aviation Administration: The Ontogenesis of a High‐Reliability Organization

Although the high‐reliability organization (HRO) literature identifies several attributes that differentiate HROs from other types of organizations, these studies do not explain how an HRO comes into being, nor do they provide a means to gauge or measure the extent to which an organization exhibits the specified features. This article reports the results of a 97‐year longitudinal case study tracking the emergence and continuation of HRO characteristics in the Federal Aviation Administration’s air traffic control operations to answer the following questions: how do HRO functions emerge in public organizations, and do policy changes lead administrative changes, or is there little relation between policy and organizational change? The analysis shows that (1) HRO characteristics emerged incrementally over an extremely long period of time, and (2) policy changes preceded organizational changes early in the process of HRO development, but the relationship of policy change to organizational change decreased in later stages.