Fatal intoxication with tianeptine (Stablon)

Tianeptine (Stablon^®), although structurally similar to tricyclic antidepressants, acts by enhancing the reuptake of serotonin. A fatal case is presented involving a 26-year-old man, found lying in bed with a “mushroom of foam” around his mouth. Empty blister packs of Stablon^® and a suicide note were found next to the body. A liquid–liquid extraction procedure with n-hexane: ethyl acetate and n-hexane: 2-propanol, followed by LC-DAD-MS analysis, using positive mode electrospray ionization was performed. The detection limit was 0.001 μg/mL. The toxicological results revealed the following tianeptine concentrations in the post-mortem samples: blood 5.1 μg/mL; urine 2.0 μg/mL; liver 23 μg/g; stomach contents 22 mg. Femoral blood analyses also revealed an ethanol concentration of 0.53 g/L. The present method was also developed and validated for the other post-mortem specimens, since no previous published data had confirmed the post-mortem distribution of tianeptine. The absence of other suitable direct causes of death (macroscopic or histological) and the positive results achieved with the toxicological analysis led the pathologist to rule that death was due to an intoxication caused by the suicidal ingestion of tianeptine in combination with alcohol.     

Determinants of black and white attitudes toward gun regulation: A research note

Should one expect different determinants of gun regulation attitudes for blacks and whites? This question is addressed using survey information on 1,361 whites and 129 black from the 1976 National Opinion Research Center General Social Survey. Results indicate that the pattern of relationships on the issue of gun regulation differ very little by race. This does not, however, preclude the possibility of racially different reasons for the same association or a racially differentiated association.     

Assessing the Risk of Secondary Transfer Via Fingerprint Brush Contamination Using Enhanced Sensitivity DNA Analysis Methods

Experiments were performed to determine the extent of cross‐contamination of DNA resulting from secondary transfer due to fingerprint brushes used on multiple items of evidence. Analysis of both standard and low copy number (LCN) STR was performed. Two different procedures were used to enhance sensitivity, post‐PCR cleanup and increased cycle number. Under standard STR typing procedures, some additional alleles were produced that were not present in the controls or blanks; however, there was insufficient data to include the contaminant donor as a contributor. Inclusion of the contaminant donor did occur for one sample using post‐PCR cleanup. Detection of the contaminant donor occurred for every replicate of the 31 cycle amplifications; however, using LCN interpretation recommendations for consensus profiles, only one sample would include the contaminant donor. Our results indicate that detection of secondary transfer of DNA can occur through fingerprint brush contamination and is enhanced using LCN‐DNA methods.     

Manners of Death in Drug‐Related Fatalities in Florida

To understand the mortality patterns among drug users and potential risk factors, we evaluated drug‐related deaths reported to the Florida Medical Examiners Commission from 2001 to 2013, by substances, demographics, and manner of death. The annual drug‐related fatalities increased by 57% from 2001 to 2013 (total n = 100,882); 51.8% were accidental, 7.9% homicide, 18.6% natural, and 19.6% suicide. The different manners of death exhibited distinct demographic profiles and drug composition. The gender gap was more prominent in homicide. Age ≥55 years was more closely associated with natural death and suicide. Age <35 years and central nervous system (CNS) stimulants including amphetamines and cocaine showed higher relative risks for accidental death and homicide, whereas CNS depressants including benzodiazepines, carisoprodol, opioids, and zolpidem were more strongly associated with accidental death and/or suicide. The findings aid in identifying populations more vulnerable to drug‐related deaths, developing targeted interventions and thereby improving efficiency of preventive efforts.     

Responding to the New Europe and the Crisis: The Adaptation of Sub-national Governments' Strategies and its Effects on Inter-governmental Relations in Spain

This article analyses the evolution of the institutional setting that the Spanish multi-level system provides for regional European Union (EU) adaptation, and the effects that recent developments of the EU (the Eastern enlargement, the Treaty reform process and the Euro-zone crisis) have had on the more or less pro-European positions and adaptive strategies of Spanish regions and on inter-governmental arrangements. It thus describes the increasing institutionalization of regional participation and EU policy coordination, both at the domestic and supra-national level, and the evolution of regional strategies, looking at its effects both on the degree of vertical and horizontal coordination, and the actual relative power and discretion of both levels of government. It argues that regional strategies have increasingly become more defensive and less pro-European and that increasing participation in European matters seemed to have favoured multi-lateralism and increased coordination without having produced further centralization until the recent crisis and associated budget consolidation targets induced new coordination requirements and a centralization of power towards the central government and EU authorities. This has, as a side-effect, reinforced some centrifugal tendencies of the system and therefore may affect the operation of IGR.     

The association between psychopathic personality traits and health-related outcomes

Purpose

Psychopathy and psychopathic personality traits (PPT) have been linked to a long list of negative life outcomes. To date, however, few studies have provided a systematic analysis of whether psychopathic personality traits contribute to increased health burden. The current study was designed to address this gap in the literature.

Method

This study analyzed data from the National Longitudinal Study of Adolescent Health and employed a measure of PPT derived from the five-factor model of personality. Analyses were conducted using OLS, logistic, and Poisson regression techniques.

Results

The results revealed that relatively higher scores on psychopathic personality traits were associated with a slight increase in a wide range of negative health outcomes. These significant associations were detected for both males and females.

Conclusions

We speak to the importance of these findings for the potential to reduce health burden among psychopaths and those who score relatively high on measures of psychopathic personality traits.     

Comparing Methods to Assess Intraobserver Measurement Error of 3D Craniofacial Landmarks Using Geometric Morphometrics Through a Digitizer Arm

Intraobserver error (INTRA‐OE) is the difference between repeated measurements of the same variable made by the same observer. The objective of this work was to evaluate INTRA‐OE from 3D landmarks registered with a Microscribe, in different datasets: (A) the 3D coordinates, (B) linear measurements calculated from A, and (C) the six‐first principal component axes. INTRA‐OE was analyzed by digitizing 42 landmarks from 23 skulls in three events two weeks apart from each other. Systematic error was tested through repeated measures ANOVA (ANOVA‐RM), while random error through intraclass correlation coefficient. Results showed that the largest differences between the three observations were found in the first dataset. Some anatomical points like nasion, ectoconchion, temporosphenoparietal, asterion, and temporomandibular presented the highest INTRA‐OE. In the second dataset, local distances had higher INTRA‐OE than global distances while the third dataset showed the lowest INTRA‐OE.     

Effect of Psychopathy, Abuse, and Ethnicity on Juvenile Probation Officers’ Decision-Making and Supervision Strategies

Probation officers exercise substantial discretion in their daily work with troubled and troubling juvenile offenders. In this experiment, we examine the effect of psychopathic features, child abuse, and ethnicity on 204 officers’ expectancies of, recommendations for, and approach to supervising, juvenile offenders. The results indicate that officers (a) have decision-making and supervision approaches that are affected by a youth’s psychopathic traits and history of child abuse—but not ethnicity; (b) view both abused youth and psychopathic youth as highly challenging cases on a path toward adult criminality; and (c) have greater hope and sympathy for abused youth than psychopathic youth. For abused youth, officers are likely to recommend psychological services and “go the extra mile” by providing greater support, referrals, and networking than is typical for their caseload. For psychopathic youth, officers expect poor treatment outcomes and are” extra strict,” enforcing rules that typically are not enforced for others on their caseload.