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51.
We suggest the use of the mismatch distribution methodology as an easy way to estimate the distance between all pairs of haplotypes present in a sample. This approach allows the evaluation of the proportion of pairs of Y-STR haplotypes that are prone to become identical by state (IBS), in one generation, by recurrent mutation, a statistic of major importance in the forensic field. The mismatch approach presents some advantages alternatively to the empirical one, since it is not necessary to have simultaneous information on STRs and SNPs, and it allows the evaluation of IBS also within-haplogroups. The estimation of IBS at an European scale showed that there is a high population substructuring for this parameter, increasing from southern-central European countries towards west and north, in accordance to what was found for Y-biallelic markers. This result seems to imply a more careful use of large databases for matching evaluation, even in the absence of population structure for general Y-STR diversity. Furthermore, mismatch distribution can be used to measure the distance between a particular haplotype and all the haplotypes in a sample. When applied to the most frequent haplotypes in Europe it revealed that the opportunity for IBS is not directly related to the frequency of a haplotype, but highly dependent on the proportion of neighbouring haplotypes--so, that reporting on the haplotype frequency for evaluating the significance of a match can be misleading. 相似文献
52.
Ferreira da Silva LA Pimentel BJ Almeida de Azevedo D Pereira da Silva EN Silva dos Santos S 《Forensic science international》2002,130(2-3):187-188
The polymorphism of nine STR loci has been studied in a sample of 598 individuals from the population of Alagoas, Northeastern Brazil. Determination of the allele frequencies as well as of several commonly used statistics in forensic and paternity testing were defined. The most polymorphic loci were TH01 and D7S317. The exact test demonstrated that the nine loci analyzed in the population have no deviation from Hardy-Weinberg equilibrium (P > 0.05). 相似文献
53.
Pros and cons in the use of SNPs in forensic kinship investigation: a comparative analysis with STRs 总被引:4,自引:0,他引:4
Recent advances in single nucleotide polymorphisms (SNPs) research have raised the possibility that these markers could replace the forensically established short tandem repeats (STRs). In this work, we compare STRs and SNPs applicability for kinship investigation in terms of expected informative content and probability of occurrence of "difficult cases" (when isolated Mendelian incompatibilities between alleged father and child are found). Since SNPs have a much lower mutation rate than STRs, these difficulties were expected to occur less frequently if SNPs were used instead of STRs. The purpose of this paper is to make some simulations allowing the estimation of how often such difficult cases are expected to occur using both types of markers and how serious can be their impact in routine work. Our results demonstrate that a battery based exclusively on SNPs matching the informative power of current STR kits would be prone, if applied to routine paternity investigation, to the occurrence of cases where the statistical evidence would be inconclusive. We infer that the introduction of a SNP based strategy, as a substitute to the now classical STR approach poses statistical problems that must be carefully evaluated. 相似文献
54.
Pinheiro MF Cainé L Pontes L Abrantes D Lima G Pereira MJ Rezende P 《Forensic science international》2005,148(2-3):221-223
Allele frequencies of sixteen autossomal short tandem repeats (STRs), D3S1358, VWA, D16S539, D8S1179, D21S11, D18S51, TH01, FGA, D5S818, D13S317, D7S820, TPOX, CSF1PO, Penta D, Penta E (included in the PowerPlex 16 kit), and the SE33 (PowerPlex ES Monoplex System SE33) were determined in a sample of 200 healthy unrelated individuals from the north of Portugal. 相似文献
55.
Effective communication of information is essential to intelligence work. This paper identifies the main obstacles to good communication: policy-related challenges; cognitive impediments; resource limitations; cultural and structural issues within intelligence communities; and technical information. To illustrate, it examines four cases when poor communication contributed to intelligence shortcomings. Via questionnaire and document survey, the study identifies the current state of practice in UK intelligence communities. The survey of visualization documents currently in use revealed errors against established principles of Information Design. Thus, to ensure better handling and dissemination of intelligence, there is a distinct need to apply Information Design principles. 相似文献
56.
A large body of research clearly demonstrates that adolescents use technology to a staggering degree and that they are one of the main groups that are vulnerable to online victimization. However, the study of cyber-stalking, which is a form of cyber-harassment victimization, has been limited to the adult population and has resulted in some controversy regarding whether fear is a definitional criterion for this phenomenon. In Portugal, the study of cyber-stalking among adolescents is limited, as it is not yet a target of scientific research, public politics or social attention. The current study assessed the cyber-stalking victimization of 627 Portuguese adolescents (12- to 16-years-old). The prevalence of victimization, the cyber-victim’s profile, cyber-stalking dynamics, the cyber-stalker’s profile, parental cyber-involvement and adolescents fear reporting were analysed. The majority of the current sample admitted to having been the victim of cyber-stalking at some point in their life, and nearly half of the adolescents reported experiencing fear after the victimization. A logistic regression model was developed to predict fear reporting. Consistent with previous research, the results indicated that fear is strongly associated with female victims and shed light on the self-perception of online risk and a number of parental involvement practices. Being the target of 1) messages of exaggerated affection, 2) persistent cyber-stalking or 3) older cyber-stalkers was also associated with fear. These results underscore the importance of understanding fear as a complex emotion that results from the interaction of different variables. Thus, it is critical to adopt fear as a key criterion of the cyber-stalking definition. Implications for social, educational, political and judicial practices are also discussed. 相似文献
57.
Ana Claudia Martins Ciconelle BSc MSc Renan Lucio Berbel da Silva DDS MSc Jun Ho Kim DDS MSc PhD Bruno Aragão Rocha MD Dênis Gonçalves dos Santos BSc Luis Gustavo Rocha Vianna BSc MSc Luma Gallacio Gomes Ferreira BSc Vinícius Henrique Pereira dos Santos Jeferson Orofino Costa DDS Renato Vicente BSc MSc PhD 《Journal of forensic sciences》2023,68(6):2057-2064
The objective of this study is to assess the performance of an innovative AI-powered tool for sex determination using panoramic radiographs (PR) and to explore factors affecting the performance of the convolutional neural network (CNN). The study involved 207,946 panoramic dental X-rays and their corresponding reports from 15 clinical centers in São Paulo, Brazil. The PRs were acquired with four different devices, and 58% of the patients were female. Data preprocessing included anonymizing the exams, extracting pertinent information from the reports, such as sex, age, type of dentition, and number of missing teeth, and organizing the data into a PostgreSQL database. Two neural network architectures, a standard CNN and a ResNet, were utilized for sex classification, with both undergoing hyperparameter tuning and cross-validation to ensure optimal performance. The CNN model achieved 95.02% accuracy in sex estimation, with image resolution being a significant influencing factor. The ResNet model attained over 86% accuracy in subjects older than 6 years and over 96% in those over 16 years. The algorithm performed better on female images, and the area under the curve (AUC) exceeded 96% for most age groups, except the youngest. Accuracy values were also assessed for different dentition types (deciduous, mixed, and permanent) and missing teeth. This study demonstrates the effectiveness of an AI-driven tool for sex determination using PR and emphasizes the role of image resolution, age, and sex in determining the algorithm's performance. 相似文献
58.
Allele frequencies for seven STRs (CD4, CSF1PO, F13A01, FES/FPS, MBPB, TH01, TPOX) were estimated from samples (sized between 300 and 940) of unrelated individuals born in North Portugal. 相似文献
59.
Pierre Guyomarc'h Ph.D. Bruno Dutailly M.Sc. Jérôme Charton M.Sc. Frédéric Santos M.Sc. Pascal Desbarats Ph.D. Hélène Coqueugniot Ph.D. 《Journal of forensic sciences》2014,59(6):1502-1516
This study presents Anthropological Facial Approximation in Three Dimensions (AFA3D), a new computerized method for estimating face shape based on computed tomography (CT) scans of 500 French individuals. Facial soft tissue depths are estimated based on age, sex, corpulence, and craniometrics, and projected using reference planes to obtain the global facial appearance. Position and shape of the eyes, nose, mouth, and ears are inferred from cranial landmarks through geometric morphometrics. The 100 estimated cutaneous landmarks are then used to warp a generic face to the target facial approximation. A validation by re‐sampling on a subsample demonstrated an average accuracy of c. 4 mm for the overall face. The resulting approximation is an objective probable facial shape, but is also synthetic (i.e., without texture), and therefore needs to be enhanced artistically prior to its use in forensic cases. AFA3D, integrated in the TIVMI software, is available freely for further testing. 相似文献
60.
The actual impact of economic growth on poverty reduction is of fundamental importance to the development agenda. This paper offers new empirical evidence on growth and poverty measured from a multidimensional perspective using the global Multidimensional Poverty Index. Results from a First Difference Estimator Model suggest that while economic growth reduces multidimensional poverty, this impact is well below a one-to-one relationship and lower than the impact of growth on income poverty. Results from a cross-section model additionally suggest that countries with higher levels of exports, higher share of industry and services and higher control of corruption have lower multidimensional poverty. 相似文献