Methodology for estimating endocranial capacity in a modern European population

Various methods have been published in the literature to estimate endocranial capacity. These are based on mathematical equations using measurements made directly on the skull or indirectly from X-rays, by filling the skull with various materials, by endocasts both physical and virtual (using 3D CT-scan reconstructions). Each method has its advantages, limits and drawbacks. A useful method is one that is simple, time-efficient, cheap, and reproducible. For this study we estimated endocranial capacity by filling the skull with calibrated glass beads. We used a thorough protocol of tamping to ensure results reproducibility. Intra- and inter-observer trials showed no significant differences. The method was applied to 130 recent French (West European) skulls (65 males and 65 females). Sexual dimorphism was studied using logistic regression functions, discriminant analysis, and neural network. The best results were obtained using the neural network, built with two hidden nodes in the hidden layer and one output node, and trained with a steepest descent algorithm. Our tests show that there is obvious sexual dimorphism (p < 10(-5)) of the weight of the skulls (623.44 ± 106.83 g in males; 548.07 ± 94.57 in females), the weight of the glass beads used to fill the skulls (2379.83 ± 228.92 g in males; 2095.95 ± 145.49 in females), and endocranial capacity (1676.47 cm(3) ± 161.26 in males; 1476.48 ± 102.49 in females), but overlapping between sexes is quite significant. The average ECC in male (1676.5 cm(3)) and in female (1476.5 cm(3)) subjects is higher than those previously published, which deserves some discussion.     

PGTandMe: social networking-based genetic testing and the evolving research model

The opportunity to use extensive genetic data, personal information, and family medical history for research purposes may be naturally appealing to the personal genetic testing (PGT) industry, which is already coupling direct-to-consumer (DTC) products with social networking technologies, as well as to potential industry or institutional partners. This article evaluates the transformation in research that the hybrid of PGT and social networking will bring about, and--highlighting the challenges associated with a new paradigm of "patient-driven" genomic research--focuses on the consequences of shifting the structure, locus, timing, and scope of research through genetic crowd-sourcing. This article also explores potential ethical, legal, and regulatory issues that arise from the hybrid between personal genomic research and online social networking, particularly regarding informed consent, institutional review board (IRB) oversight, and ownership/intellectual property (IP) considerations.     

A methodology for near-optimal computational superimposition of two-dimensional digital facial photographs and three-dimensional cranial surface meshes

The authors present a methodology for human identification based on digital superimposition techniques. This methodology computes a fast, near optimal fit between a three-dimensional skull surface mesh and a two-dimensional digitized facial photograph. Since this is done digitally, (1) the photograph can be enhanced to reduce or eliminate motion blur, overexposure or underexposure, and out-of-focus distortions; (2) previous problems with skull/photograph scaling and alignment are minimized or eliminated; and (3) the photograph and skull can be numerically correlated. Two of several test cases produced from an implementation of this methodology are also presented.     

Bright Lights,Big Cities? Metropolisation,Intergovernmental Relations,and the New Federal Urban Policy in Switzerland

Disparities between increasing urban economic power and cities' limited political autonomy have put pressure on intergovernmental relations in many countries. Some authors have claimed that this process leads to a strengthening of the position of cities with respect to higher state levels such as regions or the nation state. The aim of this article is to test this hypothesis for the case of Switzerland. In the first part, we show that, due to the existing intergovernmental framework, the current dynamics of urbanisation (which we describe as “metropolization”) have produced specific problems for governance in Swiss urban areas: spillovers in the distribution of costs and benefits, new political cleavages between core cities and surrounding communes, as well as increasing autonomy conflicts between cities and cantons. In the second part, we argue that initiatives taken in order to tackle these issues of urban governance have contributed to transforming Swiss federalism. “Politikverflechtung” is increasing in urban areas. In particular, the new federal urban policy has introduced a new vertical dimension of co‐operation between cities, cantons and the Confederation. Although Swiss cities have gained new influence in the process, we conclude that cantons still hold the key position. Therefore, like other federalist countries, Switzerland has not experienced a considerable strengthening of urban governments with respect to higher levels. Nevertheless, current developments in this area can be seen as a move away from the hierarchical pattern of co‐operative federalism towards a more heterarchical pattern of multi‐level governance in Swiss intergovernmental relations.     

L'évolution de la structure de gestion des affaires intergouvernementales au IMouveau-Brunswick: 1960–90

Sommaire: Les relations intergouvernementales du Nouveau-Brunswick ont-elles connu au cours des trois dernieres decennies des transformations de fond? Presque inexistant au debut des annees 1960, ce secteur de l'activite gouvernementale s'est developpe graduellement pour devenir, apres la victoire des Liberaux de Frank McKenna en 1987, un ministere a part entiere. Le present article se propose de decrire revolution et de determiner les principaux facteurs susceptibles d'expliquer l'absence de structures autonomes de gestion des affaires intergouvernementales de la province. Pourtant, les gouvernements Robichaud des annees 1960 et Hatfield des annees 1970 et 1980 ont souvent ete les initiateurs de projets de modernisation de l'activite gouvernementale. Comment expliquer alors qu'ils aient autant tarde a organiser la gestion des relations intergouvernementales? Ces decisions relevent-elles davantage de la societe neo-brunswickoise que de ses dirigeants politiques? En plus d'avoir consulte litterature et documentation sur le sujet, nous avons interroge plusieurs hauts fonctionnaires et hommes politiques des anciens et du present gouvernements. Un large consensus se degage parmi eux: la direction des relations intergouvernementales, etroitement controlee par les premiers ministres, leur Bureau et, a l'occasion, le Secretariat du Conseil des ministres, n'a pas souffert outre mesure de l'absence d'une bureaucratie plus structured. En depit de la recente creation du ministere des Affaires intergouvernementales, on constate que la gestion de ces affaires n'aurait pas beaucoup change pour autant. C'est toujours au Bureau du Premier ministre que sont prises les decisions cles en la matiere. Abstract: Did New Brunswick intergovernmental relations undergo fundamental changes over the last three decades? Virtually non-existent in the early 1960s, this government acrtivity sector developed gradually, emerging as a full-fledged ministry following the vitory of Frank McKenna's Liberals in 1987. The purpose of this article is to describe that change and to determine the main factors that could explain the lack of autonomous structures for managing the province's intergovernmental affairs. However, the Robichaud government in the 1960 and the hatfield government in the 1970s and 1980s often launched projects to modernize government activities. How should one therefore explain the fact that they were so late in organizing the management of intergovernmental relations? Do these decisions result more fron New Brunswick society than from its political leaders? In order to consult the relevant literture and documentation, we interviewed several high officials and politicians from current and past governments. Ther is a broad consensus among them: the management of intergovernmental relations, closely controlled by the premiers, their offices and, occasionally, the secretariat of cabinet, has not been particularly affected by the lack of a more structured bureaucracy. In spite of the recent creation of the Ministry of Intergovernmental Affairs, the management of those affairs would not appear to have changed a great deal. It is still within the premier's office that the key decisions in this field are made.     

Convergence or path dependency in policies to foster the creation of university spin-off firms? A comparison of France and the United Kingdom

This paper examines attempts by French and UK governments to fill the gap between the US and Europe with respect to the creation of academic spin-offs. Analysis of the contrasting cases of the UK and France, shows that there is no convergence of national policies to foster the creation of firms by academics. Rather, the two countries demonstrate different rationales and approaches to policy in this area. In UK, the rationale for spin-off policy is mainly to develop a third stream of financing. Spin-offs are a part of a policy to commercialize technology and knowledge created by universities. Policy is at the university level, leading to the creation of diverse structures. Public schemes bring public money directly to universities. In France, the rationale for policy towards the creation of new ventures by academics is the development of high technology new ventures as part of a technological entrepreneurship policy. The notion of a third stream of financing for universities is an argument that is never advanced. The UK has placed the universities at the heart of policies aimed at the creation of spin-offs, this is not the case in France.     

Site‐, Technique‐, and Time‐Related Aspects of the Postmortem Redistribution of Diazepam,Methadone, Morphine,and their Metabolites: Interest of Popliteal Vein Blood Sampling

Sampling site, technique, and time influence postmortem drug concentrations. In 57 cases, we studied drug concentration differences as follows: subclavian vein‐dissection/clamping versus blind stick, femoral vein‐dissection/clamping versus blind stick, right cardiac chamber, and popliteal vein‐dissection and clamping only. Cases were distributed in group #1 (all cases with both techniques), group #2 (dissection/clamping), and group #3 (blind stick). Sampled drugs were diazepam, methadone, morphine, and their metabolites. To assess PMR, mean concentrations and ratios were calculated for each group. Time‐dependent variations of blood concentrations and ratios were also assessed. Results indicate that site, method, and time may influence postmortem distribution interpretation in different ways. Popliteal blood seems less subject to PMR. In conclusion, our study is the first to evaluate concurrently three main aspects of PMR and confirms that the popliteal vein may represent a site that is more resistant to the changes seen as a result of PMR.