A rapid and sensitive method for the identification of delta-9-tetrahydrocannabinol in oral fluid by liquid chromatography-tandem mass spectrometry

This paper proposes a new approach for automatic classification of counterfeit Viagra(?) and Cialis(?) tablets using image processing and statistical analysis. A high resolution VSC 5000 is used for image acquisition in a controlled environment, and the combination of a thresholding technique with morphological operators is used to segment the tablet from the background. A statistical model based on the RGB color components of original samples is built, and the detection of counterfeit tablets was performed by checking the adherence of a test sample to the obtained distribution using the Bhattacharyya distance. Our experimental results indicated that counterfeit tablets can be effective detected using the proposed approach.     

The effect of generation and age on turnout to the European Parliament – How turnout will continue to decline in the future

Electoral turnout has been declining at national elections in almost all Western democracies. European Parliament (EP) elections have followed the same trend. We utilize a previously suggested method for separating the effect of generation, age and period and show that a major part of the decline can be attributed to the difference in turnout between pre- and post-baby-boomer generations though there are substantial differences across countries. Age has a curvilinear effect on turnout even when generation is taken into account, but the age composition has remained relatively stable over time. We utilize the estimated coefficients to predict future changes in turnout as a result of the expected shifts in the generational and age compositions over the next 30 years. The results point to a continued decline in turnout to EP elections – especially between the years of 2020 and 2040.     

Is routine histopathologic examination beneficial in all medicolegal autopsies?

Postmortem examinations are performed for a number of reasons. Medical autopsies are performed at the request of and with the consent of the next of kin of a decedent and are often requested to determine the extent of a disease process or to evaluate therapy. In contrast, medicolegal autopsies are performed by a forensic pathologist primarily to determine cause and manner of death but also to document trauma, diagnose potentially infectious diseases and report them to the appropriate agencies, provide information to families about potentially inheritable diseases, provide information to family members and investigative agencies, and testify in court. As medicolegal and hospital autopsies differ in their purpose, so do they differ in procedure. Medicolegal autopsies often include histologic analysis, but not always, as with medical autopsies. We designed a prospective study to address the question of whether or not routine histologic examination is useful in medicolegal cases, defining a routine case as one where histology would not normally be performed and where the cause and manner of death were readily apparent during the gross autopsy. We reviewed brain, heart, liver, kidney, and lung sections on 189 routine forensic cases and compared the results to the gross anatomic findings. Of the 189 cases, in only 1 case did microscopic examination affect the cause of death and in no case did microscopic examination affect the manner of death. Thus, we feel that routine microscopic examination (performing histologic examination in all cases regardless of cause and manner of death) in forensic autopsy is unnecessary. Microscopic examination should be used, as needed, in certain circumstances but is not necessary as a matter of routine.     

The last Viking King: a royal maternity case solved by ancient DNA analysis

The last of the Danish Viking Kings, Sven Estridsen, died in a.d. 1074 and is entombed in Roskilde Cathedral with other Danish kings and queens. Sven's mother, Estrid, is entombed in a pillar across the chancel. However, while there is no reasonable doubt about the identity of Sven, there have been doubts among historians whether the woman entombed was indeed Estrid. To shed light on this problem, we have extracted and analysed mitochondrial DNA (mtDNA) from pulp of teeth from each of the two royals. Four overlapping DNA-fragments covering about 400bp of hypervariable region 1 (HVR-1) of the D-loop were PCR amplified, cloned and a number of clones with each segment were sequenced. Also a segment containing the H/non-H specific nucleotide 7028 was sequenced. Consensus sequences were determined and D-loop results were replicated in an independent laboratory. This allowed the assignment of King Sven Estridsen to haplogroup H; Estrid's sequence differed from that of Sven at two positions in HVR-1, 16093T-->C and 16304T-->C, indicating that she belongs to subgroup H5a. Given the maternal inheritance of mtDNA, offspring will have the same mtDNA sequence as their mother with the exception of rare cases where the sequence has been altered by a germ line mutation. Therefore, the observation of two sequence differences makes it highly unlikely that the entombed woman was the mother of Sven. In addition, physical examination of the skeleton and the teeth strongly indicated that this woman was much younger (approximately 35 years) at the time of death than the 70 years history records tell. Although the entombed woman cannot be the Estrid, she may well be one of Sven's two daughters-in-law who were also called Estrid and who both became queens.     

Mainstream medicine versus complementary and alternative medicine in the witness box: resolving the clash of ideologies

Mainstream medical philosophy and practice differ in many respects from those of complementary and alternative medicine (CAM), differences which are explored in this article. Because of a resurgence of CAM therapies, courts and tribunals will scrutinise CAM in more and more contexts in the future. Such court cases may require the resolution of conflicts between opinions of CAM and medical experts. This article considers how courts evaluate such opinions where experts hold conflicting ideologies or philosophical approaches, and addresses the following questions: Do the opinions of CAM practitioners qualify as "expert" opinions in court? How do the courts examine the basis of such opinions? Are they systematically given less weight than the opinions of mainstream medical practitioners? Will recent procedural reforms for hearing expert evidence make it easier for courts to resolve these issues?     

A replication of “the effects of making public service employees aware of their prosocial and societal impact”

Recent studies show that simple recall tasks can make public employees more aware of the positive impact they have on others and society. This in turn increases their motivation. However, studies often draw on paid survey respondents, such as respondents recruited via Amazon MTurk, resulting in an unfortunate mismatch between test sample and target population. Addressing the need to test recall tasks among real-world public servants, we conducted a wide replication (n = 412) of a recent study by Vogel and Willems. Our findings suggest that the effect sizes of recall tasks are likely relatively smaller when deployed “in the wild.” Based on our findings, we propose three themes for a future research agenda and point practitioners to areas of attention when implementing recall tasks in real-world settings.     

The status of Armenian Christians in post-independence Israel: the first decade

Literature on the status of the Armenian population during the State of Israel's first decade is virtually nil; a scholarly investigation regarding why Armenians were not drafted into the Israel Defense Forces (IDF), when other small, non-Arab and/or non-Muslim minorities were, has not yet been written. While recognizing the paucity of available documentation, this article will seek to address both of these issues/questions in light of what sources are publicly available as well as in light of the author's own previous research into minority recruitment policies in post-independence Israel. This article will argue that while the Armenians appeared to fit nearly all of the IDF’s criteria for minority recruitment, an Armenian presence in the army ultimately would have provided few tangible advantages to the state from both a domestic and regional perspective. However, due to their non-Arab and non-Muslim identity, the Armenian population was treated as a ‘special minority’ and possessed certain unique privileges denied to other minorities in Israel. This was particularly noticeable in Haifa. However, in other ways, Armenians were treated by state authorities in a very similar manner to the far larger and more distrusted Arab population.     

Empirical evidence on the publicness of state legislative activities

Legislation would be a Samuelsonian public good if the cost of creating legislation is not a function of the number of people covered by the legislation. A straighforward test of Samuelsonian publicness is undertaken by estimating the cost of producing legislation as a function of population and other variables, using cross-sectional data from the states of the United States for the years 1965, 1975, and 1985. The empirical results indicate that while legislation does have some degree of publicness, legislation is mostly a private good, and that it has been becoming increasingly less public over time.     

Arms control: Focus on denial and deception

Conclusion Arms control continues to be a key element of U.S. national security policy. Yet, to be a constructive part of our national strategy, stringent arms control verification is required. Of late, the government has moved from agreements incorporating effective monitoring methods to multilateral, feel-good agreements that are very difficult, if not impossible, to monitor. Since the United States is not going to violate agreements, we could be placed at a long-term strategic disadvantage.