26-Locus Y-STR typing in a Bhutanese population sample

26 Y chromosome short tandem repeat (STR) loci were amplified in a sample of 856 unrelated males from Bhutan, using two multiplex polymerase chain reaction (PCR) assays. The first multiplex is the Y-STR 20plex described by Butler et al. [J.M. Butler, R. Schoske, P.M. Vallone, M.C. Kline, A.J. Redd, M.F. Hammer, A novel multiplex for simultaneous amplification of 20 Y chromosome STR markers, Forensic Sci. Int. 129 (2002) 10-24], and the second is a novel (but overlapping) 14plex that targets six additional Y-STRs (DYS425, DYS434, DYS435, DYS436, DYS461, DYS462) and also amplifies the amelogenin locus. The 26-loci give a discriminating power of 0.9957, though even at this resolution one haplotype occurs 24 times. We identify novel alleles at five loci and microvariants at a further three, which were characterised by sequencing. Extended (11-locus) haplotypes for these samples have been submitted to the Y-STR Haplotype Reference Database (YHRD).     

Stress and suicide are we well-equipped to study this issue?

Stress almost always precedes suicidality. Stress also is a harbinger of a variety of psychiatric disorders, most notably depression. Depression is a major precursor of suicidal behavior. Consequently, the question of whether stress is an epiphenomenon or a decisive factor in the causation of suicidality and (certain forms of) mood disorders is crucial. Certainty about this question can only be obtained when it can be demonstrated that stress phenomena may induce changes in brain functioning similar to the ones supposedly associated with suicidality and with (certain forms of) depression. Since the phenomenology of stress syndromes, as well as their emotional intensity, are highly variable, careful definition of the stress syndrome to be studied is a first requirement. In studies into the significance of stress in the occurrence of suicidality and depression, this degree of finesse has not been achieved. The major shortcomings have been discussed. These should be systematically addressed to provide research into the relation between stress and psychopathology with the necessary acuity.     

The failure of the Philippine presidential system

This article explains why the Philippines continues to be a weak state and that the prospects for building a stronger, sustainable state are dim under the current political system. Philippine elections are won through a mix of popularity, populism and money politics. This seriously undermines the strength of the state since the oligarchy expects returns for their investment in a candidates campaign. The extraordinary power of the president and the ministers makes it possible to repay and buy the loyalty of the financial and political oligarchy by giving away jobs within the bureaucracy. A predatory political elite, whose prime goal it has been to win the coming elections and to assure that their family interests are protected and promoted further undermines the independence and meritocracy of the Philippine bureaucracy. I argue that as long as the current presidential system continues to exist in the Philippines the chances for building a strong state are slight.This article represents an abbreviated version of the introduction of the MA thesis of Bastiaan van de Loo titled: The Election and Presidency of Joseph Estrada: A Case Study of Philippine Politics. The complete version of the thesis can be found on http://www.thephilippines.org     

Sharing benefits of globalisation through an EU-ASEAN FTA?

In the aftermath of the stalled launch of a new WTO round in Seattle in 1999, Singapore and Japan initiated a joint study into a possible bilateral Free Trade Agreement (FTA). The resulting New-Age Economic Partnership Agreement was signed in 2002, reduced barriers in trade and investment in goods as well as services, technical standards and public procurement. Other FTAs followed including a US-Singapore FTA in 2003. In response, other ASEAN countries initiated negotiations towards bilateral FTAs, such as Thailand with India and Malaysia with Japan etc. Moreover, China declared its intention to enter into a FTA with the ASEAN by 2012. The failure at Cancun in 2003 implies that the Doha Development Agenda will not be achieved within the time-frame set. In this environment, the question of a feasibility of an inter-regional EU-ASEAN FTA is investigated. ASEANs trade policy regime is opening up and the gains of further tariff elimination will be modest, because most ASEAN countries already apply low tariffs, while those of the EU on import from ASEAN are low as well – e.g. for Singapore the tariff rate is merely 1.04 per cent (trade weighted). Nevertheless, a further reduction will benefit both EU and ASEAN because a significant share of imports is intra-firm trade, with EU firms operating from ASEAN as a production platform for the EU markets. However, for an EU-ASEAN FTA to be worthwhile, it must generate benefits on issues relating to non-tariff barriers to trade, esp. technical standards, SPS and mutual recognition of testing. Further significant benefits to EU and ASEAN may be realised by advancing liberalisation of international trade in services (e.g. banking and insurance licences, air and sea transport). Reducing restrictions on foreign direct investment in selectedservice sectors is bound to enhance investment flows from the EU to ASEAN.This article draws extensively on a study directed by the author with Dr. Paul Brenton, Prof. Ludo Cuyvers and Prof. Patrick Messerlin (van der Geest et al. 2003). Research assistance by Ms. Vanessa Sumo and Ms. Roberta Zavoretti is gratefully acknowledged. The views expressed in this article are solely those of the author and do not reflect the views of the European Institute for Asian Studies or of its sponsors. The author is solely responsible for any remaining errors or inaccuracies. All comments are welcomed at w.vandergeest@eias.org     

On the economic theory of interest groups: Towards a group frame of reference in political economics

This paper evaluates the development of the economic theory of interest groups. Although there is important progress, many substantial lacunae in our knowledge exist. I argue that part of the problem is the way Public Choice theory developed. Methodological individualism has led to an overindividualized ('a- social') view of human behavior. Furthermore, the importance of imperfect information has been underexposed. Acknowledging the essentially social character of human behavior and the lack of information leads to the conclusion that a more prominent place should be given to the role of social groups. A shift towards a “group frame of reference” is advocated.     

Electoral participation in the Netherlands: Individual and contextual influences

Abstract Research into electoral participation has produced two traditions, one focusing mainly on individual level explanations while the second concentrates primarily on aggregate level explanations. By bringing these two research approaches together, we are not only able to explain individual electoral participation more thoroughly, but we also gain additional insight into the influence of aggregate level characteristics on individual behavior. We combine eight National Election Studies held in the Netherlands between 1971 and 1994 enabling us to study variation on the individual and the contextual (aggregate) level, including interactions between these two levels. Findings show that the addition of contextual characteristics form a significant improvement to an individual level model predicting electoral participation. Findings also confirm our expectation that the influence of individual characteristics such as education or political interest is dependent upon contextual characteristics describing for instance the salience of the election.     

Analytical problems with putrefaction in a fatal case involving ergotamine and pentazocine

A 29-year-old male drug addict was found dead at the bottom of a staircase. Analysis of the acid-hydrolized blood showed the presence of pentazocine and two characteristic compounds that contained L-phenylalanine and D-proline, linked together by peptide bounds. It was shown that the latter two components could emanate from the peptide part of ergotamine under the conditions used. It seemed likely that, at the time of analysis, pentazocine and ergotamine were present at concentrations far above therapeutic values. A third component in the blood could not be identified.