An unusual case of driving under the influence of enflurane

An unusual case of driving under the influence of the volatile anaesthetic enflurane is reported. A markedly affected anaesthetist was sniffing at an enflurane-moistened handkerchief before he crashed into a lorry at a red traffic light. In the blood sample enflurane (2.92 mg/l) as well as diclofenac (0.28 mg/l) and 4-aminophenazone (24.4 mg/l) were found. The way of driving and the accident and the deficiency symptoms could be explained by the central suppressing effects of enflurane. The physician was considered as impaired and not suitable to drive at the time of the incidence.     

Quantitation using GC-TOF-MS: example of bromazepam

Time-of-flight mass spectrometry (TOF-MS) offers new perspectives for forensic toxicology. Qualitative and quantitative analyses of a mixture of three selected benzodiazepines (diazepam, nordazepam and bromazepam) were used to compare gas chromatography (GC-TOF-MS, quadrupole GC-MS, GC-ECD) and liquid chromatography (HPLC-DAD) data. Method validation parameters like LOD, LOQ, S/N-ratios reflect the capabilities of GC-TOF-MS. Five-point calibrations for bromazepam in human peripheral blood (50, 100, 160, 200, 300 ng/ml) using medazepam as internal standard (1000 ng/ml) were performed. The calibrations using GC-TOF-MS (using the fragments of m/z 236 and 288), GC-ECD (dual system) and HPLC-DAD (at 235 nm) all showed correlation coefficients close or superior to 0.99. Quadrupole GC-MS data was not used in the comparison of extracted samples due to the low sensitivity in the full scan mode. Two analyses of real cases concerning bromazepam are presented. In the first case, the presence or absence of bromazepam could not be established with both HPLC-DAD and GC-ECD due to background signals. The extracted ion chromatograms and spectrum traces after the analysis with the GC-TOF-MS could clearly excluded the presence of bromazepam. The second case illustrates the quantitation of bromazepam, where both HPLC-DAD and GC-ECD were unable to give satisfactory results, again due to interfering background signals. The analyses performed on the GC-TOF-MS-system demonstrated high sensitivity and also high selectivity due to the high quality of mass spectra obtained. The advantages of GC-TOF-MS make it a promising analytical technique for forensic toxicology.     

Testing a Model of Resistance to Peer Pressure Among Mexican-Origin Adolescents

This study examined the factors associated with resistance to peer pressure toward antisocial behaviors among a sample of Mexican-origin adolescents (n=564) living in a large Southwestern city in the U.S. A model examining the influence of generational status, emotional autonomy from parents, and self-esteem on resistance to peer pressure was tested independently for boys and girls. Gender differences emerged in the factors that influenced resistance to peer pressure. Results indicated that resistance to peer pressure was influenced by generational status and emotional autonomy from parents for both boys and girls. However, self-esteem was found to influence resistance to peer pressure only for boys.Mayra Y. Bámaca is a graduate student in Family and Human Development at Arizona State University. Her research interests include adolescent development among ethnically diverse populations, the influence of contextual factors in development, parenting adolescents, and resiliency among Latino adolescents and their families. This work was based on the master’s thesis of the first author.Adriana J. Uma?a-Taylor received her Ph.D. from the University of Missouri-Columbia and is currently an Assistant Professor of Family and Human Development at Arizona State University. Her research interests include ethnic identity formation during adolescence and resilience among Latino adolescents and their families.This study was supported, in part, by a grant to the second author from the Fahs Beck Fund for Research and Experimentation of the New York Community Trust.     

Rise of the Automobiles: the costs of increased NO2 pollution in China's changing urban environment

China's rapidly growing motor vehicle fleet is changing the makeup of its urban atmosphere. While the two major problem pollutants historically have been particulates and sulfur dioxide, the growth in the number of automobiles has generated substantially increased levels of nitrogen dioxide (NO₂). This paper examines and values the mortality health effects (reduced premature deaths) from cleaning up these three pollutants. Findings indicate that valued gains from reduced air pollution mortality can average 3% of a city's GDP. Moreover, the growing auto fleet may generate a ten-fold increase in NO₂-based mortality costs and offset other, ongoing cleanup efforts in many Chinese cities. Specifically, the paper explores how the increasing number of automobiles might diminish or offset environmental cleanup activities focused upon particulate and sulfur dioxide pollution.     

Explaining Taiwan's Revisionist Diplomacy

Taiwan is a revisionist power. Its independence movement challenges a vital status-quo interest of mainland China's opposition to a de jure Taiwan declaration of independence and maintaining, however ambiguously, Taiwan's commitment to the ‘one-China’ formulation. Why is it that a small and vulnerable island off the coast of a great power has continued to challenge the vital interest of that great power and risk war? Adopting a ‘levels of analysis’ approach to Taiwan's mainland policy, this paper addresses this question by examining four prevalent explanations for Taiwan's revisionist diplomacy: (1) the mainland deterrent is ineffective, reflecting Taiwan doubts about either mainland capabilities or mainland resolve to wage a retaliatory war; (2) in an example of the security dilemma in alliance politics, US commitment to Taiwan, although aimed at deterring PRC use of force, encourages Taiwan to challenge the status quo because the Taiwan leadership is confident of US intervention and US ability to defend Taiwan; (3) because of the development of a ‘Taiwan identity’ and of corresponding domestic political pressures, the Democratic Progressive Party has been compelled to adopt a pro-independence policy; (4) Chen Shui-bian has a personal commitment to Taiwan independence and has been willing to challenge the mainland's interest in one-China, despite risk of heightened conflict and regardless of domestic political considerations.